anti-Catenin beta-1 (CTNB1) Antibodies

CTNB1 encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse CTNB1 CTNB1 12387 Q02248
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More Antibodies against Catenin beta-1 Interaction Partners

Mouse (Murine) Catenin beta-1 (CTNB1) interaction partners

  1. Exogenous or paracrine sources of NO promote the specification towards the myocyte lineage and expression of cardiac sarcomeric proteins of adult cardiac progenitor cells. This is contingent upon the expression and activity of the alpha1 subunit of guanylyl cyclase in CPC that is necessary for NO-mediated inhibition of the canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway.

  2. AP-2 beta (show TFAP2B Antibodies) and beta-catenin (show CTNNB1 Antibodies) interact both in vitro through GST pull-down assays and in vivo by co-immunoprecipitation. We further identified the interaction regions to the DNA-binding domain of AP-2 beta (show TFAP2B Antibodies) and the 1-9 Armadillo (show PKP1 Antibodies) repeats of beta-catenin (show CTNNB1 Antibodies).

  3. TIEG1 (show KLF10 Antibodies) is involved in regulating the canonical Wnt (show WNT2 Antibodies) signaling pathway in bone through multiple mechanisms of action.

  4. Activation of WNT/b-catenin activity improved cardiac contractility and ameliorated intraventricular conduction defects in LmnaH222P/H222P mice, which was associated with increased expression of myocardial connexin 43. These results indicate that decreased WNT/b-catenin contributes to the pathophysiology of LMNA cardiomyopathy and that drugs activating b-catenin may be beneficial in affected individuals

  5. Oncogenic beta-catenin (show CTNNB1 Antibodies) and PI3K activities interact in the acquisition of multiple cancer-related phenotypes in organoids grown in Matrigel.

  6. We further found that knockdown of Kif2a (show KIF2A Antibodies) decreased the protein level of b-catenin, which is a critical molecule for neocortical neurogenesis. Together, these results reveal an important function of Kif2a (show KIF2A Antibodies) in embryonic neocortical neurogenesis

  7. Data show that both Wnt1 (show WNT1 Antibodies)-cre and P0-cre are similarly effective in deleting beta-catenin (show CTNNB1 Antibodies) in the neural crest.

  8. HIRA (show HIRA Antibodies), in cooperation with Setd1A (show SETD1A Antibodies), modulates beta-catenin (show CTNNB1 Antibodies) expression to regulate neural stem cell proliferation and neurogenesis.

  9. Wnt/beta-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers

  10. cadherin 2 (CDH2 (show CDH2 Antibodies)) and CDH4 (show CDH4 Antibodies) cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B (show PTPN1 Antibodies)) and alpha- and beta-catenins.

Zebrafish Catenin beta-1 (CTNB1) interaction partners

  1. Mechanistically, Hif-3alpha2 binds to beta-catenin (show CTNNB1 Antibodies) and destabilizes the nuclear beta-catenin (show CTNNB1 Antibodies) complex.

  2. Nuclear beta-catenin (show CTNNB1 Antibodies) is an indication of an activated Wnt (show WNT2 Antibodies) pathway, therefore suggesting a possible role for Wnt (show WNT2 Antibodies) signalling during zebrafish tooth development and replacement.

  3. Findings suggest that microRNA 19b (miR (show MYLIP Antibodies)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1 (show CTNNB1 Antibodies).

  4. Custos binds to beta-catenin (show CTNNB1 Antibodies) in a Wnt (show WNT2 Antibodies) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin (show CTNNB1 Antibodies).

  5. The role of the beta-catenin (show CTNNB1 Antibodies) mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.

  6. The Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)

  7. This study demonstrated that beta-catenin (show CTNNB1 Antibodies)/Wnt (show WNT2 Antibodies) signaling is initially required to activate cell-cycle re-entry in Muller glia following injury and that Wnt (show WNT2 Antibodies) signaling subsequently controls the fate of the progeny of those cell divisions.

  8. A novel role for Eaf1 (show EAF1 Antibodies) and Eaf2 (show EAF2 Antibodies) in inhibiting canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling, which might form the mechanistic basis for Eaf1 (show EAF1 Antibodies) and Eaf2 (show EAF2 Antibodies) tumor suppressor activity.

  9. Ccr7 (show CCR7 Antibodies) functions during axis formation as a GPCR (show GPRC6A Antibodies) to inhibit beta-catenin (show CTNNB1 Antibodies), likely by promoting Ca(2 (show CA2 Antibodies)+) transients throughout the blastula.

  10. ctnnb1 (show CTNNB1 Antibodies) and ctnnb2 regulate multiple processes of laterality development in zebrafish embryos through similar and distinct mechanisms.

Cow (Bovine) Catenin beta-1 (CTNB1) interaction partners

  1. Bovine herpesvirus 1 transiently increased beta-catenin (show CTNNB1 Antibodies) protein levels in bovine kidney cells, but not in rabbit skin cells.

  2. These results demonstrate that activation of AKT (show AKT1 Antibodies) is required for gonadotropin regulation of CTNNB1 (show CTNNB1 Antibodies) accumulation and subsequent ovarian E2 production.

  3. beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.

  4. These data demonstrate for the first time that FSH (show BRD2 Antibodies) regulates CTNNB1 (show CTNNB1 Antibodies) protein and WNT2 (show WNT2 Antibodies) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (show WNT2 Antibodies) signaling in ovarian steroidogenesis and follicular growth of cattle.

  5. These data provide evidence that testosterone increases cellular beta-catenin (show CTNNB1 Antibodies) content which promotes the expression of beta-catenin (show CTNNB1 Antibodies)-targeted genes and myogenesis in the muscle-derived stem cells of cattle.

  6. that beta-catenin (show CTNNB1 Antibodies) is a plasma membrane-associated protein (show PDZK1IP1 Antibodies) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.

  7. This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin (show CTNNB1 Antibodies).

  8. TGF-beta3 (show TGFB3 Antibodies) induces the chondrogenic differentiation of pericytes by inducing Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling and T-cell factor-induced gene transcription.

  9. cAMP/PKA regulation of GSK3beta (show GSK3b Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling contributes to the increase in progesterone production in corpus luteum.

Pig (Porcine) Catenin beta-1 (CTNB1) interaction partners

  1. Results highlight a potential role for the beta-catenin (show CTNNB1 Antibodies)/Wnt (show WNT2 Antibodies) and Notch (show NOTCH1 Antibodies) signalling pathways during the infection of crypt cells by L. intracellularis.

  2. Flutamide exposure led to decreased beta-catenin (show CTNNB1 Antibodies) in corpus luteum of mid/late pregnancy.

  3. beta-catenin (show CTNNB1 Antibodies) signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.

  4. Wnt3a (show WNT3A Antibodies) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin (show CTNNB1 Antibodies) siRNA.

  5. beta-catenin (show CTNNB1 Antibodies) controls myocardin (show MYOCD Antibodies)-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes

  6. beta-Catenin (show CTNNB1 Antibodies) plays a critical role in mediating TGF-beta1 (show TGFB1 Antibodies)-induced myofibroblast differentiation in aortic valve interstitial cells.

  7. scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin (show CTNNB1 Antibodies)

  8. Data show that Wnt3a (show WNT3A Antibodies) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.

  9. TNF-alpha (show TNF Antibodies) inhibits adipogenesis through stabilization of beta-catenin (show CTNNB1 Antibodies) protein in porcine preadipocytes.

Rabbit Catenin beta-1 (CTNB1) interaction partners

  1. Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and Hedgehog (show SHH Antibodies) signaling

  2. These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin (show CTNNB1 Antibodies) pathway in rabbit articular chondrocytes.

Catenin beta-1 (CTNB1) Antigen Profile

Protein Summary

This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins\; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene.

Gene names and symbols associated with anti-Catenin beta-1 (CTNB1) Antibodies

  • catenin (cadherin associated protein), beta 1 (Ctnnb1) antibody
  • catenin (cadherin-associated protein), beta 1 (ctnnb1) antibody
  • catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1) antibody
  • catenin (cadherin-associated protein), beta 1, 88kDa (Ctnnb1) antibody
  • Bfc antibody
  • Catnb antibody
  • CHBCAT antibody
  • ctnnb antibody
  • id:ibd2058 antibody
  • Mesc antibody
  • wu:fb73e10 antibody
  • wu:fi81c06 antibody
  • wu:fk25h01 antibody

Protein level used designations for anti-Catenin beta-1 (CTNB1) Antibodies

beta-catenin , catenin beta-1 , beta catenin

GENE ID SPECIES
12387 Mus musculus
30265 Danio rerio
539003 Bos taurus
397657 Sus scrofa
477032 Canis lupus familiaris
100125985 Oryctolagus cuniculus
395964 Gallus gallus
100732604 Cavia porcellus
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