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Cathepsin A Proteins (CTSA)

CTSA encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. Additionally we are shipping Cathepsin A Antibodies (85) and Cathepsin A Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CTSA 296370  
CTSA 5476 P10619
CTSA 19025 P16675
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Top Cathepsin A Proteins at antibodies-online.com

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Escherichia coli (E. coli) Wild boar His tag,GST tag 100 μg Log in to see 11 to 13 Days
$880.00
Details
HOST_Escherichia coli (E. coli) Dog His tag,GST tag 100 μg Log in to see 11 to 13 Days
$950.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CTSA Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , , , ,
, ,
Mouse (Murine) ,
,

Top referenced Cathepsin A Proteins

  1. Human CTSA Protein expressed in Human Cells - ABIN2002941 : Galjart, Gillemans, Harris, van der Horst, Verheijen, Galjaard, dAzzo: Expression of cDNA encoding the human "protective protein" associated with lysosomal beta-galactosidase and neuraminidase: homology to yeast proteases. in Cell 1988 (PubMed)
    Show all 3 references for ABIN2002941

  2. Mouse (Murine) CTSA Protein expressed in Human Cells - ABIN2007700 : Hiraiwa: Cathepsin A/protective protein: an unusual lysosomal multifunctional protein. in Cellular and molecular life sciences : CMLS 2001 (PubMed)
    Show all 3 references for ABIN2007700

More Proteins for Cathepsin A (CTSA) Interaction Partners

Arabidopsis thaliana Cathepsin A (CTSA) interaction partners

  1. It is shown by dot-immunoblotting that At3g52840 is the gene expressing Gal-2 (show LGALS2 Proteins) which is associated with the cell wall in Arabidopsis.

Human Cathepsin A (CTSA) interaction partners

  1. Galactosialidosis is a rare lysosomal storage disease caused by a combined deficiency of GM1 beta-galactosidase (beta-gal (show GLB1 Proteins)) and neuraminidase (show NEU Proteins) secondary to a defect of a lysosomal enzyme protective protein/cathepsin A (PPCA) and mutation in CTSA gene.

  2. Case Report: galactosialidosis with novel mutations of CTSA gene diagnosed using placental pathology.

  3. We identified compound heterozygous mutations in the CTSA gene, responsible for causing galactosialidosis

  4. correct nomenclature of mutations for this gene is discussed; clinical and mutational analyses of 4 cases with rare infantile form of galactosialidosis; identified 3 novel nucleotide changes, 2 resulting in missense mutations and the third, resulting in the p.Gln406* stop codon; complexity of the clinical phenotypes in GS reflects dual functions of PPCA/CTSA

  5. Catalytic function, tissue distribution and substrates of cathepsin A are discussed as well as inhibition of cathepsin A as an emerging strategy for the treatment of heart failure.

  6. The Cathepsin C (show CTSC Proteins) releases the glycosidases from complexes formed with cathepsin A, and reinstates their activity.

  7. Our data suggest that CatA (show CAT Proteins) is involved in the C-terminal fine-tuning of antigenic T cell epitopes in human APC (show APC Proteins).

  8. Increased activity of beta-galactosidase (show GLB1 Proteins) in the peritoneal fluid is associated with gynecologic cancers and pelvic inflammatory disease

  9. effects of GLB1 (show GLB1 Proteins), PPCA and NEU1 (show NEU1 Proteins) gene mutations on elastogenesis in skin fibroblasts

  10. Results describe the hydrodynamic properties of PPCA, NEU1 (show NEU1 Proteins), and a complex of the two proteins and identified multiple binding sites on both proteins.

Mouse (Murine) Cathepsin A (CTSA) interaction partners

  1. our results define the biological role of mammalian serine carboxypeptidase Scpep1 and suggest that Scpep1 and CathA together participate in the control of ET-1 (show EDN1 Proteins) regulation of vascular tone and hemodynamics

  2. Loss of the cathepsin A results in the lysosomal storage disease galactosialidosis. However, mice with a catalytically inactive cathepsin A enzyme show no signs of this disease.

  3. characterization of human PPCA, including N-terminal sequencing of the two cleavage products

  4. the compromised halo cells, due to PPCA deficiency within their lysosomes, cannot function properly and as a result there is a recruitment of macrophages in the intertubular space

  5. PPCA deficiency causes structural changes to the blood-epididymal barrier as evidenced by lanthanum nitrate and Cldns expression that affects the luminal environment of the epididymis, resulting in altered sperm motility.

  6. CathA acts in vivo as an endothelin-1 (show EDN1 Proteins)-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.

  7. Results indicate a novel role for PPCA/cathepsin A in osteoclastogenesis via down-regulation of NF-kappaB p50 (show NFKB1 Proteins)/p65 (show NFkBP65 Proteins) activity and suggest a new function for PPCA as an NF-kappaB (show NFKB1 Proteins)-degrading enzyme in addition to its known multifunctional properties.

  8. Results describe the hydrodynamic properties of PPCA, NEU1 (show NEURL Proteins), and a complex of the two proteins and identified multiple binding sites on both proteins.

  9. The N-terminal N-glycan of NEU1 (show NEURL Proteins) is indispensable for its function, whereas the C-terminal N-glycan appears to be non-essential. The omission of the second N-glycan can be compensated for by upregulating the expression of PPCA

Cow (Bovine) Cathepsin A (CTSA) interaction partners

  1. PPGB gene is not responsible for the lysosomal storage disease of Japanese Black cattle.

Cathepsin A (CTSA) Protein Profile

Protein Summary

This gene encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Cathepsin A Proteins (CTSA)

  • cathepsin A (Ctsa)
  • beta-galactosidase 2 (BGAL2)
  • cathepsin A (CTSA)
  • AU019505 protein
  • beta-galactosidase 2 protein
  • GLB2 protein
  • GSL protein
  • NGBE protein
  • PPCA protein
  • PPGB protein

Protein level used designations for Cathepsin A Proteins (CTSA)

lysosomal protective protein , protective protein for beta-galactosidase , protective protein for beta-galactosidase (galactosialidosis) , beta-galactosidase 2 , beta-galactosidase protective protein , carboxypeptidase C , carboxypeptidase L , carboxypeptidase Y-like kininase , carboxypeptidase-L , deamidase , lysosomal carboxypeptidase A , protective protein cathepsin A , urinary kininase

GENE ID SPECIES
296370 Rattus norvegicus
824450 Arabidopsis thaliana
428163 Gallus gallus
5476 Homo sapiens
19025 Mus musculus
518169 Bos taurus
100156798 Sus scrofa
611146 Canis lupus familiaris
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