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The protein encoded by CTSB is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally we are shipping Cathepsin B Kits (66) and Cathepsin B Proteins (47) and many more products for this protein.
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Human Polyclonal Cathepsin B Primary Antibody for FACS, IHC - ABIN222979
Rybicka, Balce, Chaudhuri, Allan, Yates: Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner. in The EMBO journal 2012
Show all 3 references for ABIN222979
Human Polyclonal Cathepsin B Primary Antibody for IP, ELISA - ABIN1996943
Gogiel, Wola?ska, Galewska, Kinalski, Sobolewski, Romanowicz: Cathepsin B in human myometrium and in uterine leiomyomas at various stages of tumour growth. in European journal of obstetrics, gynecology, and reproductive biology 2015
Human Polyclonal Cathepsin B Primary Antibody for IF (p), IHC (p) - ABIN687412
Liu, Tang, Zhang, Li, Yuan, Wang: Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats. in Neural regeneration research 2014
Cathepsin B is involved in the programmed cell death of the fat body during B. mori metamorphosis, and that cathepsin B and cathepsin B contribute to B (show TDO2 Antibodies). mori metamorphosis.
Cathepsin B knockdown in oral cancer cells reduces cell migration.
the authors applied the technique of nanoelectrode arrays to try to detect and compare cathepsin B activities in normal and breast cancer cells. It was found that protease activity correlated positively with the degree of malignancy cancer cells.
shedding of surface proteins by extracellular cathepsins impacts intracellular signaling as demonstrated for regulation of Ras GTPase (show RACGAP1 Antibodies) activity.
High cathepsin is associated with drug resistance in neuroblastoma (show ARHGEF16 Antibodies).
The expressions of cathepsin B strongly correlated with the Mini-Mental State Examination scores of the Alzheimer disease. patients
Integrin alphavbeta3 (show ITGAV Antibodies) is required for cathepsin B-induced hepatocellular carcinoma progression
The serum level of cathepsin L (show CTSL1 Antibodies) decreased with age, while cathepsin B remained no significant difference between young and aged individuals
enhanced activity and expression of cathepsin B contributes to an increased remodelling of extracellular matrix that favours leiomyoma growth
SCD5 (show SCD5 Antibodies) impairs SPARC (show SPARC Antibodies) and cathepsin B secretion in human melanoma cells and intracellular pH acidification.
data suggest that CTSB is a pathophysiologically relevant protease that activates ENaC (show SCNN1A Antibodies) in cystic fibrosis (show S100A8 Antibodies) airways
Aggregatibacter actinomycetemcomitans invasion of macrophages induces interleukin-1beta production through reactive oxygen species and cathepsin B.
Findings indicate that Ctsb-/- BMDC display more pro-Th1 (show HAND1 Antibodies) properties than their WT and Ctsl (show CTSL1 Antibodies)-/- counterparts, and therefore suggest that Ctsb down-regulates the Th1 (show HAND1 Antibodies) response to L. major.
Cathepsin B showed the highest protein levels in the anterior segments of the gastrointestinal tract, whereas the highest activity was observed in the jejunum
CtsB and CtsL (show CTSL1 Antibodies) are essential in alpha-syn lysosomal degradation
Reactive oxygen species and cathepsin B activities are necessary for maximal iNOS (show NOS2 Antibodies) induction in C. muridarum-infected macrophages.
CTSB protein functions as a necessary modulator of hypertrophic response by regulating TNF-alpha (show TNF Antibodies)/ASK1 (show MAP3K5 Antibodies)/JNK (show MAPK8 Antibodies) signaling pathway involved in cardiac remodeling.
Abeta (show APP Antibodies) oligomers, but not fibrils, induce IL-1beta (show IL1B Antibodies) production in primary microglia in a cathepsin B- and reactive oxygen species -dependent manner.
Cathepsin B produces full-length amyloid-beta (Ab(1-40/42)) and pyroglutamate amyloid-beta (pyroGluAb(3-40/42) and is a key drug target for treating Alzheimer's disease by reducing these amyloid-beta species
cysteine cathepsins B and S can directly cleave Rip1 (show RALBP1 Antibodies)
these results support a causative role of VEGF in perinatal cerebral hemorrhage and implicate its downstream proteases as potential therapeutic targets.
The cathepsin B deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
evidence shows cathepsin B activity may not be redox regulated; however, the stability of the enzyme at neutral pH is dependent on redox potential, and on the presence of oxidising agents.
Overexpressing cathepsin B reduced the Vascular Endothelial Growth Factor-dependent tube response
The peptides, all of which contain a C-terminal free acid, were tested as inactivators of bovine cathepsin B, in an attempt at exploiting the known and, amongst the cysteine proteinases, unique carboxy dipeptidyl peptidase (show ACE Antibodies) activity of the protease.
Findings showed that CTSB facilitates adipogenesis, and its effect is associated with fibronectin degradation and Wnt/b-catenin signaling pathway.
CTSB may be required to remodel endometrial and placental tissues for close apposition between maternal and fetal vasculatures and to facilitate transplacental transport of gases, micronutrients (amino acids, glucose), and macromolecules (proteins).
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.
, cathepsin B-2744
, cathepsin B-1674
, cathepsin B-84
, cathepsin B-3098
, cathepsin B-16D2
, cathepsin B-1874
, cathepsin B-3483
, cathepsin B-10270
, APP secretase
, amyloid precursor protein secretase
, cathepsin B1
, cysteine protease