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Cathepsin D Proteins (CTSD)

CTSD encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally we are shipping Cathepsin D Antibodies (318) and Cathepsin D Kits (84) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CTSD 1509 P07339
CTSD 13033 P18242
CTSD 171293  
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Top Cathepsin D Proteins at antibodies-online.com

Showing 10 out of 57 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human GST tag Cathepsin D (CTSD) (AA 67-403), (partial) protein (GST tag) 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$206.55
Details
HOST_HEK-293 Human His tag 10 μg Log in to see 2 to 3 Days
$304.50
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Cricetulus griseus His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$1,049.40
Details

CTSD Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, ,
Mouse (Murine) , , ,

Rat (Rattus) ,
,

Top referenced Cathepsin D Proteins

  1. Human Cathepsin D Protein expressed in HEK-293 - ABIN2666497 : Bidère, Lorenzo, Carmona, Laforge, Harper, Dumont, Senik: Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. in The Journal of biological chemistry 2003 (PubMed)
    Show all 8 references for ABIN2666497

  2. Human Cathepsin D Protein expressed in HEK-293 Cells - ABIN2180944 : Zhang, Li, Martin, Aebersold: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. in Nature biotechnology 2003 (PubMed)
    Show all 3 references for ABIN2180944

  3. Human Cathepsin D Protein expressed in Escherichia coli (E. coli) - ABIN1046778 : Faust, Kornfeld, Chirgwin: Cloning and sequence analysis of cDNA for human cathepsin D. in Proceedings of the National Academy of Sciences of the United States of America 1985 (PubMed)
    Show all 3 references for ABIN1046778

More Proteins for Cathepsin D (CTSD) Interaction Partners

Zebrafish Cathepsin D (CTSD) interaction partners

Silk Worm Cathepsin D (CTSD) interaction partners

  1. These results suggest that the ecdysone response elements are vital for activation of the promoter by 20-hydroxyecdysone (20E) in the larval fat body and further support the crucial role of ecdysone signaling to control cathepsin D gene transcription.

Human Cathepsin D (CTSD) interaction partners

  1. Fibroblasts from Niemann-Pick type C (NPC (show NPC1 Proteins)) disease patients with low levels of NPC1 (show NPC1 Proteins) protein have high amounts of procathepsin D but reduced quantities of the mature protein, thus showing a diminished cathepsin D activity.

  2. Data indicate that cathepsin D (CD) protein is elevated in the retinas of diabetic mice and serum of human patients with diabetic macular edema (DME).

  3. Data show that co-silencing of tricho-rhino (show RHNO1 Proteins)-phalangeal-syndrome (TRPS1) and cathepsin D (Cath-D) in breast cancer cells (BCC) affects the transcription of cell cycle and proliferation.

  4. Transcellular transmission of alpha-synuclein aggregates is increased in CTSD mutated cells.

  5. Serum CatD activity as a marker of healthy endogenous phagocytosis and remodeling was impaired in patients with new-onset cardiac dysfunction.

  6. study provides evidence that hTERT overexpression is responsible for the upregulation of the cysteine protease (show CTSB Proteins) cathepsin D by regulating EGR-1 (show EGR1 Proteins) to activate invasiveness in cancer progression

  7. A proteomics workflow identified CTSD as an over-expressed protein in osteosarcomas and pulmonary metastases and may thus serve as a new biomarker for individualized treatment regimes for patients with osteosarcomas, even at metastastic stage.

  8. the clues provided by the yeast model unveiled a novel CatD function in the degradation of damaged mitochondria when autophagy is impaired, which protects colorectal cancer cells from acetate-induced apoptosis.

  9. Fenhexamid and cyprodinil can promote ovarian cancer metastasis by increasing the protein expression of cathepsin D via an estrogen receptor (show ESR1 Proteins) dependent pathway.

  10. Variations in CTSD and MnSOD (show SOD2 Proteins) showed no association with the development of Alzheimer's Disease, whereas the presence of the Ala224Val polymorphism in CTSD had a positive association with the development of AD

Mouse (Murine) Cathepsin D (CTSD) interaction partners

  1. Data indicate that cathepsin D (CD) protein is elevated in the retinas of diabetic mice and serum of human patients with diabetic macular edema (DME).

  2. This study demonistrated that Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.

  3. Post-translational modifications drive CatD into the nucleus to cleave Histone 3 in the involuting mammary gland.

  4. Increased lysosomal storage in CatD KO mice causes oxidative damage in brain pericytes, subsequently resulting in an increased vessel diameter and enhanced permeability of the BBB.

  5. Mouse prolactin (show PRL Proteins) was proteolytically cleaved by Cath D between amino acids 148 and 149. N-terminal prolactin (show PRL Proteins) fragment and Cath D expression increased during mammary gland involution.

  6. Cathepsin D was not inherent to sperm themselves, but rather of epididymal origin and was presumably transported to the sperm surface via epididymosomes.

  7. TGase 2 (show TGM2 Proteins) may regulate the balance between cell survival and cell death through the modulation of CTSD levels.

  8. These results suggest that increased release/activation of cathepsin D can trigger neurodegeneration and possibly development of Niemann-Pick type C disease pathology.

  9. Relative position of thyroglobulin (Tg (show TG Proteins))peptide epitopes are identified based on homology to known Ctsd cleavage sites in rabbit Tg.

  10. Three cathepsin D-specific cleavage sites in Bid (show BID Proteins), Phe24, Trp48, and Phe183, were identified.

Cow (Bovine) Cathepsin D (CTSD) interaction partners

  1. Association of polymorphisms in calpain 1 (show CAPN1 Proteins), (mu/I) large subunit, calpastatin (show CAST Proteins), and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.

  2. findings strongly suggest a link between the lysosomal dysfunction of cathepsin D and the etiology of Alzheimer's disease

Pig (Porcine) Cathepsin D (CTSD) interaction partners

Rabbit Cathepsin D (CTSD) interaction partners

  1. The effect of heavy metal cations on the activity of cathepsin D, was studied.

Cathepsin D (CTSD) Protein Profile

Protein Summary

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.

Gene names and symbols associated with Cathepsin D Proteins (CTSD)

  • cathepsin D (ctsd)
  • cathepsin D (LOC398557)
  • cathepsin D (Cathd)
  • cathepsin d (AaeL_AAEL006169)
  • cathepsin D (LOC100136761)
  • cathepsin D (CTSD)
  • cathepsin D (ctsD)
  • cathepsin D (catd)
  • cathepsin D (Ctsd)
  • cathepsin D (LOC100101595)
  • CatD protein
  • Cathd protein
  • CD protein
  • CLN10 protein
  • CPSD protein
  • CTSD protein
  • DDBDRAFT_0205785 protein
  • DDBDRAFT_0215012 protein
  • DDB_0205785 protein
  • DDB_0215012 protein
  • DKFZp469J0315 protein
  • fb93e11 protein
  • fj17b09 protein
  • LOC398557 protein
  • LOC100136761 protein
  • wu:fb93e11 protein
  • wu:fj17b09 protein

Protein level used designations for Cathepsin D Proteins (CTSD)

etID16901.18 , cathepsin D , aspartic protease , cathepsin d , preprocathepsin D , ceroid-lipofuscinosis, neuronal 10 , lysosomal aspartyl peptidase , lysosomal aspartyl protease , cathepsin D (lysosomal aspartyl peptidase) , cathepsin D (lysosomal aspartyl protease) , prepro-cathepsin D, prepro-CD

GENE ID SPECIES
65225 Danio rerio
398557 Xenopus laevis
443721 Xenopus laevis
692768 Bombyx mori
5567565 Aedes aegypti
100136761 Oncorhynchus mykiss
100137367 Papio anubis
100168373 Acyrthosiphon pisum
100172401 Pongo abelii
8622052 Dictyostelium discoideum AX4
100528208 Ictalurus punctatus
1509 Homo sapiens
101094625 Felis catus
13033 Mus musculus
171293 Rattus norvegicus
282883 Bos taurus
483662 Canis lupus familiaris
494568 Sus scrofa
100101595 Oryctolagus cuniculus
100735735 Cavia porcellus
396090 Gallus gallus
443060 Ovis aries
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