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Cathepsin K Proteins (CTSK)

The protein encoded by CTSK is a lysosomal cysteine proteinase involved in bone remodeling and resorption. Additionally we are shipping Cathepsin K Antibodies (172) and Cathepsin K Kits (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CTSK 1513 P43235
CTSK 13038 P55097
CTSK 29175 O35186
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Top Cathepsin K Proteins at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Macaca fascicularis His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Rabbit His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Rat His tag Cathepsin K (CTSK) (AA 115-329) protein (His tag) expressed in E. coli 1 mg Log in to see 56 to 66 Days
$2,531.83
Details
Yeast Macaca fascicularis His tag Cathepsin K (CTSK) (AA 115-329) protein (His tag) expressed in E. coli 1 mg Log in to see 56 to 66 Days
$2,531.83
Details

CTSK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
,
Rat (Rattus) ,

More Proteins for Cathepsin K (CTSK) Interaction Partners

Human Cathepsin K (CTSK) interaction partners

  1. There is an increase in levels of CATK in type 1 Gaucher patients compared to the control group. In the patient group, CATK showed higher levels in patients with bone damage compared to those without it.

  2. elevated levels of CatK are closely associated with the presence of chronic heart failure and that the measurement of circulating CatK provides a noninvasive method of documenting and monitoring the extent of chronic heart failure

  3. Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model.

  4. Matrix-metalloproteinase-9 (show MMP9 Proteins) is cleaved and activated by cathepsin K.

  5. Sequence analysis of the patient's CTSK gene revealed homozygosity for a missense mutation (c.746T>C) in exon 6, which leads to amino change (p.Ile249Thr) in the mature CTSK protein

  6. The presence of high levels of inactive proforms of cathepsin K in GBM tissues and cells indicate that in GBM the proteolytic/collagenolytic role is not its primary function but it plays rather a different yet unknown role.

  7. Two compounds have sizable effects on enzyme activity using interstitial collagen as a natural substrate of cathepsin K and four compounds show a significantly stabilizing effect on cathepsin K.

  8. Studies indicate cathepsin X as a target for improving diagnosis and treating cancer patients.

  9. SDF-1alpha is involved in homing of CXCR4 (show CXCR4 Proteins)+ GSLCs and leukocytes and that cathepsin K and osteopontin (show SPP1 Proteins) are involved in the migration of GSLCs out of the niches

  10. one cathepsin K molecule binds to collagen-bound glycosaminoglycans at the gap region and recruits a second protease molecule that provides an unfolding and cleavage mechanism for triple helical collagen

Pig (Porcine) Cathepsin K (CTSK) interaction partners

  1. The CTSK marker was associated with back fat thickness and lean cuts (P < 0.01), and average daily gain and feed:gain ratio (P < 0.05) estimated breeding values.

Rabbit Cathepsin K (CTSK) interaction partners

  1. The authors showed CTSK upregulation in human lung specimens and elevated serum CTSK levels of patients with tuberculosis, compared with controls.

  2. Down-regulation of cathepsin K in synovium at the initial stage of osteoarthritis significantly accelerated cartilage degeneration.

Mouse (Murine) Cathepsin K (CTSK) interaction partners

  1. The effects of muscarinic receptor (show CHRM5 Proteins) M3 knockout on cathepsin K expression, bone density and biomechanical properties of bone are reported.

  2. Cathepsin K expression is increased in the bone of a diabetic mouse model.

  3. Data suggest Ctsk gene, key gene upregulated during osteoclast differentiation, is transcriptionally activated during cell hypoxia-induced mitochondrial dysfunction/disruption; hnRNPA2 (heterogeneous ribonucleoprotein A2) is coactivator in this process.

  4. cathepsin K knockout attenuates age-related decline in cardiac function via suppressing caspase (show CASP3 Proteins)-dependent and caspase (show CASP3 Proteins)-independent apoptosis

  5. Data (including data from studies in knockout/transgenic mice) suggest that Ctsk is involved in inflammatory response and bone resorption in both rheumatoid arthritis and periodontitis; thus, Ctsk appears to play a role in osteoimmune responses.

  6. In a mouse model of post-traumatic osteoarthritis, cathepsin K activity was significantly increased in injured knees relative to uninjured knees.

  7. Gene deletion of cathepsin K in mice accelerated callus size resolution, significantly increased callus mineralized mass, and improved mechanical strength as compared to wild type mice.

  8. synergism between HIV proteins and pro-atherogenic shear stress to increase endothelial cell expression of the powerful protease cathepsin K

  9. in addition to its other effects, the absence of CatK in OCP limits their ability to engraft in a repairing fracture callus compared to WT OCP.

  10. Cardiac mammalian target of rapamycin (show FRAP1 Proteins) and extracellular signal-regulated kinases (ERK (show EPHB2 Proteins)) signaling cascades were upregulated by pressure overload, the effects of which were attenuated by cathepsin K knockout.

Cathepsin K (CTSK) Protein Profile

Protein Summary

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

Gene names and symbols associated with Cathepsin K Proteins (CTSK)

  • cathepsin K-like (LOC100054991)
  • 26-29kD-proteinase (26-29-p)
  • cathepsin K (CTSK)
  • cathepsin K (ctsk)
  • Cathepsin K (catk)
  • cathepsin O (CTSO)
  • cathepsin K (catk)
  • cathepsin K (Ctsk)
  • 26/29kD-proteinase protein
  • AI323530 protein
  • anon-SAGE:Wang-123 protein
  • catK protein
  • CG8947 protein
  • CTS02 protein
  • CTSK protein
  • CTSO protein
  • CTSO1 protein
  • CTSO2 protein
  • Dmel\\CG8947 protein
  • l(3)s3635 protein
  • MMS10-Q protein
  • Ms10q protein
  • OC-2 protein
  • PKND protein
  • PYCD protein
  • wu:fa95f03 protein
  • wu:fb08b05 protein
  • zgc:110367 protein

Protein level used designations for Cathepsin K Proteins (CTSK)

26,29kDa proteinase , 26-29 kD-proteinase , 26-29-p-PA , 26-29kDa proteinase , 26-29kd prot , CG8947-PA , anon-SAGE:Wang-123 , cathepsin K , etID33526.16 , Cathepsin K , cathepsin O , cathepsin O1 , cathepsin O2 , cathepsin X , JTAP-1 , protein OC-2 , Cat K , minisatellite 10q detected by probe MMS10 , cathepsin K (pycnodysostosis) , cathepsin K preproprotein

GENE ID SPECIES
100054991 Equus caballus
39547 Drosophila melanogaster
457278 Pan troglodytes
550475 Danio rerio
779889 Xenopus (Silurana) tropicalis
100127265 Xenopus laevis
100195370 Salmo salar
461567 Pan troglodytes
482665 Canis lupus familiaris
616804 Bos taurus
699868 Macaca mulatta
100528180 Ictalurus punctatus
1513 Homo sapiens
395818 Gallus gallus
397569 Sus scrofa
100009334 Oryctolagus cuniculus
13038 Mus musculus
29175 Rattus norvegicus
608843 Canis lupus familiaris
513038 Bos taurus
100718267 Cavia porcellus
101108972 Ovis aries
574112 Macaca mulatta
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