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The protein encoded by CTSS, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. Additionally we are shipping Cathepsin S Antibodies (120) and Cathepsin S Proteins (26) and many more products for this protein.
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McComb, Shutinoski, Thurston, Cessford, Kumar, Sad: Cathepsins limit macrophage necroptosis through cleavage of Rip1 kinase. in Journal of immunology (Baltimore, Md. : 1950) 2014
Show all 2 references for ABIN411885
Human Cathepsin S ELISA Kit for Sandwich ELISA - ABIN415099
Gu, Lü, Chen, Zhou, Song, Jin, Liu: Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions: an in vivo study using intravascular ultrasound. in Chinese medical journal 2010
Show all 2 references for ABIN415099
p41 (show EPB41 ELISA Kits) fragment is also shown to reduce the secretion of interleukin-12 (IL-12 (show IL12A ELISA Kits)/p70 (show ANXA6 ELISA Kits)) during the subsequent maturation of treated dendritic cells.
shedding of surface proteins by extracellular cathepsins impacts intracellular signaling as demonstrated for regulation of Ras GTPase (show RACGAP1 ELISA Kits) activity.
the essential role of autophagy-regulated early ROS (show ROS1 ELISA Kits) in triggering late apoptotic signaling
Cathepsin S cleaves near the N-terminus of PAR2 (show F2RL1 ELISA Kits) to expose a novel tethered ligand, KVDGTS.
Increased plasma CTSS concentration is associated with atherogenesis.
results identify Cat-S as a biased agonist of PAR2 (show F2RL1 ELISA Kits) that causes PAR2 (show F2RL1 ELISA Kits)- and TRPV4 (show TRPV4 ELISA Kits)-dependent inflammation and pain.
Its stability at neutral pH and potent proteolytic activity on extracellular matrix components mean that cathepsin S may contribute significantly to cartilage degradation and may thus be considered a potential drug target in joint diseases.
High cathepsin S expression at the primary site correlates with decreased brain metastasis-free survival in breast cancer patients.
cathepsin S and chemerin (show RARRES2 ELISA Kits) only correlated positively with insulin (show INS ELISA Kits) resistance and inflammation
Cat S-mediated autophagic flux is an important mechanism for inducing M2-type polarization of tumor-associated macrophages, which leads to tumor development
Data show that cathepsins S (CatS) regulates CCL2 (show CCL2 ELISA Kits) chemokine (show CCL1 ELISA Kits) expression by modulation of CD74 (show CD74 ELISA Kits) antigen processing.
Cathepsin S activates MrgprC11 (show MRGPRX1 ELISA Kits) and evokes receptor-dependent scratching in mice.
cathepsin S deficiency alters the balance between adipocyte and osteoblast differentiation, increases bone turnover, and changes bone microarchitecture. Therefore, bone and fat metabolisms should be monitored when using cathepsin S inhibitors clinically
Cathepsin S contributes to macrophage migration via degradation of elastic fibre integrity to facilitate neointima formation of vein grafts
cysteine cathepsins B and S can directly cleave Rip1 (show RALBP1 ELISA Kits)
CatS also reduced myocardial Smad2 (show SMAD2 ELISA Kits) and Smad3 (show SMAD3 ELISA Kits) activation and extra domain A fibronectin (show FN1 ELISA Kits) expression
These results show a peripheral pivotal role of CatS in the development of neuropathic pain through the antigen-specific activation of CD4 (show CD4 ELISA Kits)(+) T-cells
High cathepsin S promotes cancer growth and neovascularization.
Provide direct evidence that Cat S plays an important role in abdominal aortic aneurysm formation in apoE (show APOE ELISA Kits)-deficient mice.
These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs.
The cathepsin S deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, cathepsin S, gene 1
, Cathepsin S
, Cat S