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Cathepsin S Proteins (CTSS)

The protein encoded by CTSS, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. Additionally we are shipping Cathepsin S Antibodies (120) and Cathepsin S Kits (52) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CTSS 1520 P25774
CTSS 13040  
CTSS 50654 Q02765
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Top Cathepsin S Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
$319.00
Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
$547.80
Details
HOST_HEK-293 Human Un-conjugated 50 μg Log in to see 2 to 3 Days
$1,013.25
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$679.80
Details
HOST_Escherichia coli (E. coli) Cow His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_HEK-293 Human His tag   0.05 mg Log in to see 2 to 3 Days
$584.38
Details

CTSS Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
,
Mouse (Murine) , ,
,
Rat (Rattus) , ,

Top referenced Cathepsin S Proteins

  1. Mouse (Murine) Cathepsin S Protein expressed in Human Cells - ABIN3216406 : Wiederanders, Brömme, Kirschke, von Figura, Schmidt, Peters: Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S. in The Journal of biological chemistry 1992 (PubMed)
    Show all 5 references for ABIN3216406

  2. Human Cathepsin S Protein expressed in Human Cells - ABIN2002951 : Shi, Webb, Foster, Knoll, Lemere, Munger, Chapman: Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. in The Journal of biological chemistry 1994 (PubMed)
    Show all 4 references for ABIN2002951

  3. Human Cathepsin S Protein expressed in Escherichia coli (E. coli) - ABIN1098767 : Fengler, Brandt: Three-dimensional structures of the cysteine proteases cathepsins K and S deduced by knowledge-based modelling and active site characteristics. in Protein engineering 1999 (PubMed)
    Show all 2 references for ABIN1098767

  4. Human Cathepsin S Protein expressed in HEK-293 Cells - ABIN2180950 : Burkard, Planyavsky, Kaupe, Breitwieser, Bürckstümmer, Bennett, Superti-Furga, Colinge: Initial characterization of the human central proteome. in BMC systems biology 2011 (PubMed)

More Proteins for Cathepsin S (CTSS) Interaction Partners

Human Cathepsin S (CTSS) interaction partners

  1. levels of cathepsin S and hsCRP observed in women who later developed breast cancer may provide prognostic information regarding tumor development and need to be evaluated in prospective studies.

  2. p41 (show EPB41 Proteins) fragment is also shown to reduce the secretion of interleukin-12 (IL-12 (show IL12A Proteins)/p70 (show ANXA6 Proteins)) during the subsequent maturation of treated dendritic cells.

  3. shedding of surface proteins by extracellular cathepsins impacts intracellular signaling as demonstrated for regulation of Ras GTPase (show RACGAP1 Proteins) activity.

  4. the essential role of autophagy-regulated early ROS (show ROS1 Proteins) in triggering late apoptotic signaling

  5. Cathepsin S cleaves near the N-terminus of PAR2 (show F2RL1 Proteins) to expose a novel tethered ligand, KVDGTS.

  6. Increased plasma CTSS concentration is associated with atherogenesis.

  7. results identify Cat-S as a biased agonist of PAR2 (show F2RL1 Proteins) that causes PAR2 (show F2RL1 Proteins)- and TRPV4 (show TRPV4 Proteins)-dependent inflammation and pain.

  8. Its stability at neutral pH and potent proteolytic activity on extracellular matrix components mean that cathepsin S may contribute significantly to cartilage degradation and may thus be considered a potential drug target in joint diseases.

  9. High cathepsin S expression at the primary site correlates with decreased brain metastasis-free survival in breast cancer patients.

  10. cathepsin S and chemerin (show RARRES2 Proteins) only correlated positively with insulin (show INS Proteins) resistance and inflammation

Mouse (Murine) Cathepsin S (CTSS) interaction partners

  1. Demonstrate the utility of intracellular caspase 1 (show CASP1 Proteins) and extracellular CTSS proteolytic activities as surrogate biomarkers of lysosomal rupture and acute inflammation.

  2. Fluorogen substrate, Mca (show RSPH1 Proteins)-GRWPPMGLPWE-Lys (show LYZ Proteins)(Dnp)-DArg-NH2 can detect CTSS activities in mouse antigen presenting cells.

  3. Data show that cathepsins S (CatS) regulates CCL2 (show CCL2 Proteins) chemokine (show CCL1 Proteins) expression by modulation of CD74 (show CD74 Proteins) antigen processing.

  4. Cathepsin S activates MrgprC11 (show MRGPRX1 Proteins) and evokes receptor-dependent scratching in mice.

  5. cathepsin S deficiency alters the balance between adipocyte and osteoblast differentiation, increases bone turnover, and changes bone microarchitecture. Therefore, bone and fat metabolisms should be monitored when using cathepsin S inhibitors clinically

  6. results identify Cat-S as a biased agonist of PAR2 (show F2RL1 Proteins) that causes PAR2 (show F2RL1 Proteins)- and TRPV4 (show TRPV4 Proteins)-dependent inflammation and pain.

  7. Cathepsin S contributes to macrophage migration via degradation of elastic fibre integrity to facilitate neointima formation of vein grafts

  8. cysteine cathepsins B and S can directly cleave Rip1 (show RALBP1 Proteins)

  9. CatS also reduced myocardial Smad2 (show SMAD2 Proteins) and Smad3 (show SMAD3 Proteins) activation and extra domain A fibronectin (show FN1 Proteins) expression

  10. These results show a peripheral pivotal role of CatS in the development of neuropathic pain through the antigen-specific activation of CD4 (show CD4 Proteins)(+) T-cells

Pig (Porcine) Cathepsin S (CTSS) interaction partners

  1. These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs.

Cow (Bovine) Cathepsin S (CTSS) interaction partners

  1. The cathepsin S deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.

Cathepsin S (CTSS) Protein Profile

Protein Summary

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene names and symbols associated with Cathepsin S Proteins (CTSS)

  • cathepsin S-like (LOC100054948)
  • cathepsin S (ctss-a)
  • cathepsin S (ctss-b)
  • cathepsin S (ctss)
  • cathepsin S (CTSS)
  • cathepsin S, gene 2 (ctss.2)
  • Cathepsin S (cats)
  • cathepsin S (Ctss)
  • cathepsin S (LOC100101598)
  • Cathepsin S (LOC100153090)
  • cats protein
  • ctss protein
  • ctss-a protein
  • ctss-b protein
  • ctss.1 protein
  • MGC69026 protein
  • MGC80097 protein

Protein level used designations for Cathepsin S Proteins (CTSS)

cathepsin S , cathepsin S, gene 1 , Cathepsin S , Cat S

GENE ID SPECIES
100054948 Equus caballus
380516 Xenopus laevis
446505 Xenopus laevis
448203 Xenopus (Silurana) tropicalis
457277 Pan troglodytes
496647 Xenopus (Silurana) tropicalis
100049247 Oryzias latipes
100196462 Salmo salar
100305010 Ictalurus punctatus
100579205 Nomascus leucogenys
1520 Homo sapiens
13040 Mus musculus
50654 Rattus norvegicus
100101598 Oryctolagus cuniculus
100722492 Cavia porcellus
100153090 Sus scrofa
327711 Bos taurus
403400 Canis lupus familiaris
425657 Gallus gallus
780472 Ovis aries
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