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The protein encoded by CAV2 is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. Additionally we are shipping Caveolin 2 Antibodies (111) and Caveolin 2 Proteins (24) and many more products for this protein.
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Human Caveolin 2 ELISA Kit for Sandwich ELISA - ABIN418644
Sugie, Mukai, Yamasaki, Kamibeppu, Tsukino, Kamoto: Significant Association of Caveolin-1 and Caveolin-2 with Prostate Cancer Progression. in Cancer genomics & proteomics 2015
CAV-1 (show CAV1 ELISA Kits) and -2 have roles in progression of prostate neoplasms
Caveolin-2 expression is necessary for the control of E2-dependent cellular proliferation of MCF-7 cells.
variant in CAV2 is associated with increased age-of-onset of P. aeruginosa airway infection in cystic fibrosis (show S100A8 ELISA Kits) cohort.
The minor allele G of rs17588172 in the CAV1 (show CAV1 ELISA Kits)-CAV2 locus is associated with decreased expression of CAV1 (show CAV1 ELISA Kits) and CAV2 in some tissues, marginally with intraocular pressure elevation, and consequently with increased susceptibility to high-tension glaucoma.
Results present initial characterization of key proteins Cav2 and CFL1 as cellular factors that colocalize with M in viral inclusions and filaments and ZNF502 protein which appears to interact with RSV M in the nucleus.
The implication of the caveolin genes, CAV1 (show CAV1 ELISA Kits)/CAV2, as a common genetic factor influencing both IOP variations and POAG may provide new insights of the underlying mechanism leading to glaucoma and glaucomatous visual field loss.
CAV1 (show CAV1 ELISA Kits)/CAV2 SNPs were associated significantly with primary open-angle glaucoma overall, particularly among women.
Our findings did not correspond with previous positive results, suggesting that CAV1 (show CAV1 ELISA Kits)-CAV2 variants studied in the present study are not important risk factors for Normal Tension Glaucoma.
This study does not support an association between CAV2 variation and kidney transplant survival.
The combination of the expression of the genes for PPARgamma (show PPARG ELISA Kits), STMN1 (show STMN1 ELISA Kits) and CAV2 was significantly predictive for early recurrence of non-muscle-invasive bladder cancer
We concluded that caveolin-2 is most probably involved in regulation of pro-inflammatory responses of BMDMs, triggered via activation of ERK1/2 (show MAPK1/3 ELISA Kits).
Cav-2 expressed in tumor microenvironment may potentially become a novel target for cancer therapy
In contrast to wild-type-Cav-2, retroviral re-expression of Y19/27F-Cav-2 in Cav-2 knockout endothelial cells did not affect anti-proliferative effect of TGF-beta (show TGFB1 ELISA Kits) compared to empty vector.
Data show that the balance between caveolin-1 (show CAV1 ELISA Kits) and caveolin-2 is important for iNOS (show NOS2 ELISA Kits) expression and ultimately for sepsis outcome.
The negative regulation of transforming growth factor-beta1 signaling and function by caveolin 2 is independent of caveolin 1 (show CAV1 ELISA Kits) expression levels and is not because of changing targeting of caveolin 1 (show CAV1 ELISA Kits) protein to plasma membrane lipid raft/caveolar domains.
Data suggest that Cav-2 negatively regulates lung endothelial cell proliferation and cell cycle progression.
Data show that amino acids K47-K57 of Cav-1 (show CAV1 ELISA Kits) are a highly conserved sequence in Cav-1 (show CAV1 ELISA Kits) and Cav-3 (show CAV3 ELISA Kits) proteins, and that expression of either K47-K57 deletion Cav-1 (show CAV1 ELISA Kits) mutant or wild-type Cav-2 that lacks this sequence exhibits a non-polarized distribution pattern.
Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae
Splice variant of mouse caveolin-2 mRNA, encoding an isoform lacking the C-terminal domain, localized to the endoplasmic reticulum, while the authentic caveolin-2 was distributed to the Golgi and the plasma membrane along with caveolin-1 (show CAV1 ELISA Kits).
Src (show SRC ELISA Kits)-induced phosphorylation of caveolin-2 on tyrosine 19.
miR (show MYLIP ELISA Kits)-29a mediated Caveolin 2 regulation, modulating the activation state of CDC42 (show CDC42 ELISA Kits), in intestinal Salmonella infection, is reported.
The interaction of caveolin-2 with caveolin-1 (show CAV1 ELISA Kits) could play an important role in caveolae biogenesis and shear stimulated mechano-signal transduction.
caveolin-2 is an integral component of the trafficking network in the intestinal cells of C. elegans
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462).
, caveolin 2
, caveolae protein, 20-kD
, caveolin 2 isoform a and b