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STS1 encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. Additionally we are shipping Cbl-Interacting Protein Sts-1 Proteins (5) and many more products for this protein.
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The results show that the interaction between STS-1 and ShcA (show SHC1 Antibodies) is regulated in response to EGF receptor (show EGFR Antibodies) activation.
The study reveals a role of CBL (show CBL Antibodies) in restricting myeloid proliferation of human AML1 (show RUNX1 Antibodies)-ETOinduced leukemia, and identifies UBASH3B as a potential target for pharmaceutical intervention.
targeting Aurora B (show AURKB Antibodies) to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells
These results show that TULA-2 is a target of miR (show MLXIP Antibodies)-148a-3p
This recovery involves the phosphorylation of p70 (show ANXA6 Antibodies) independent of mTOR (show FRAP1 Antibodies).
results demonstrate the importance of STS-1 in regulating IFN-alpha (show IFNA Antibodies)-induced autophagy in B cells
UBASH3B is a functional target of anti-invasive microRNA200a that is down-regulated in triple negative breast cancer. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity.
Ablation of TULA-2 resulted in hyperphosphorylation of Syk (show SYK Antibodies) and its downstream effector phospholipase C (show PLC Antibodies)-gamma2 as well as enhanced GPVI (show GP6 Antibodies)-mediated platelet functional responses.
Sts-1 and Sts-2 (show UBASH3A Antibodies) bind to Cbl (show CBL Antibodies) and inhibit endocytosis of receptor tyrosine kinases
hsp70 (show HSP70 Antibodies) inhibits apoptosis upstream and downstream of the mitochondria and is a promising therapeutic target for reversing drug-resistance in chronic myeloid leukemia (show BCL11A Antibodies)-blast crisis and acute myeloid leukemia (show BCL11A Antibodies) cells.
Sts-1 and Sts-2 (show UBASH3A Antibodies) are not required for the immune control of murine herpesvirus 68 in a normal course of gammaherpesvirus infection.
The absence of TULA-2 and also the relative level of TULA-2 expression modulates FcgammaRIIA-mediated platelet reactivity and heparin-induced thrombocytopenia in vivo.
dephosphorylation of Tyr (show TYR Antibodies)(P)(346) may be considered an important "checkpoint" in the regulation of Syk (show SYK Antibodies) activation process. Putative biological functions of TULA-2-mediated dephosphorylation of Tyr (show TYR Antibodies)(P)(346) may include deactivation of receptor-activated Syk (show SYK Antibodies) or suppression of Syk (show SYK Antibodies) activation by suboptimal stimulation.
Biochemical analysis identified STS-1 and STS-2 (show UBASH3A Antibodies) as direct phosphatases of FLT3 (show FLT3 Antibodies) and c-KIT (show KIT Antibodies).
results demonstrate the importance of STS-1 in regulating IFN-alpha (show IFNA Antibodies)-induced autophagy in B cells.
The lack of TULA-2 facilitates T-cell responses to TCR/CD3 (show CD3E Antibodies) stimulation, thus exacerbating T-cell-dependent inflammation.
TULA-2 negatively regulates osteoclast differentiation and function.
Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase (show YES1 Antibodies) Syk (show SYK Antibodies) interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation.
Syk (show SYK Antibodies) is a bona fide TULA-2 substrate in platelets.
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
Cbl-interacting protein Sts-1
, SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate
, T-cell ubiquitin ligand 2
, cbl-interacting protein p70
, nm23-phosphorylated unknown substrate
, suppressor of T-cell receptor signaling 1
, tyrosine-protein phosphatase STS1/TULA2
, ubiquitin-associated and SH3 domain-containing protein B