Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) ELISA Kits

human homolog may play a role in regulation of transcription and splicing [RGD, Feb 2006].. Additionally we are shipping Cdc2-Related Kinase, Arginine/serine-Rich Antibodies (36) and Cdc2-Related Kinase, Arginine/serine-Rich Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
CRKRS 51755 Q9NYV4
CRKRS 69131 Q14AX6
CRKRS 192350 Q3MJK5
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Top Cdc2-Related Kinase, Arginine/serine-Rich ELISA Kits at antibodies-online.com

Showing 4 out of 7 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 46.9 pg/mL 78-5000 pg/mL 96 Tests Log in to see 13 to 16 Days
$436.50
Details
Mouse 78-5000 pg/mL 96 Tests Log in to see 15 to 18 Days
$1,029.60
Details
Rat
0.156-10 ng/mL 96 Tests Log in to see 15 to 18 Days
$1,029.60
Details
Cow
96 Tests Log in to see 15 to 18 Days
$1,029.60
Details

More ELISA Kits for Cdc2-Related Kinase, Arginine/serine-Rich Interaction Partners

Fruit Fly (Drosophila melanogaster) Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) interaction partners

  1. Cdk12 suppresses genes that support metabolic functions in stressed conditions. Cdk12 is not a generally essential Pol II kinase and is not required for the transcription of essential and housekeeping genes at least in adult tissues.

  2. CDK12 plays a role in controlling the epigenetic transition between euchromatin and heterochromatin, suggesting a chromatin regulatory mechanism in neuronal behaviors.

  3. The phosphorylation of the C-terminal domain of the RNA polymerase II by Cdk12 provides an elegant mechanism in regulating timed splicing of newly synthesized mRNA molecules.

Human Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) interaction partners

  1. In Ovarian Cancer patients CDK12 loss is consistently associated with a particular genomic instability pattern characterized by hundreds of tandem duplications

  2. Structures of CDK12/CycK (show CCNK ELISA Kits) complexes solved in the presence of AMP (show APRT ELISA Kits)-PNP (show NP ELISA Kits).

  3. Data show that most mutations prevent formation of the cyclin-dependent kinase 12 (Cdk12)/cyclin K (CycK (show CCNK ELISA Kits)) complex, rendering the kinase inactive.

  4. CDK12 affects RNA processing events in two distinct ways: Indirectly through generating factor-binding phospho-epitopes on the CTD of elongating RNAPII and directly through binding to specific factors

  5. CDK12 and CDK13 (show CDK13 ELISA Kits) losses in HCT116 cells preferentially affect expression of DNA damage response.

  6. CDK12 plays an important role in cotranscriptional processing of c-FOS transcripts

  7. CDK12 has properties that should confirm interest in its use as a biomarker.

  8. many CDK12 mutations are an unrecognized cause of HR defects in ovarian cancers

  9. CDK12 interacts with cyclin K (show CCNK ELISA Kits) and is required to maintain embryonnic stem cell self-renewal.

  10. Cyclin (show PCNA ELISA Kits) K1 is the primary cyclin (show PCNA ELISA Kits) partner for CDK12/CrkRS and it is required for activation of CDK12/CrkRS to phosphorylate the C-terminal domain of RNA Pol II.

Mouse (Murine) Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) interaction partners

  1. Report on the functions of Cdk12 during neural development in vivo, proposes a dual role for Cdk12 in neurogenesis and late stage neuronal migration via 2 distinct pathways

  2. The findings of this study suggest that Cdk12 and Cdk13 (show CDK13 ELISA Kits) regulate axonal elongation through a common signaling pathway that modulates Cdk5 (show CDK5 ELISA Kits) expression.

Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) Antigen Profile

Antigen Summary

human homolog may play a role in regulation of transcription and splicing

Gene names and symbols associated with CRKRS

  • CG7597 gene product from transcript CG7597-RB (Cdk12) antibody
  • Cdc2-related kinase, arginine/serine-rich (LOC100354313) antibody
  • cyclin-dependent kinase 12 (CDK12) antibody
  • cyclin-dependent kinase 12 (Cdk12) antibody
  • 1810022J16Rik antibody
  • AC017581 antibody
  • AI646528 antibody
  • anon-WO0140519.165 antibody
  • cg7597 antibody
  • Crk7 antibody
  • CRKR antibody
  • Crkrs antibody
  • D11Ertd752e antibody
  • dCDK12 antibody
  • Dmel\\CG7597 antibody
  • gi24668141 antibody
  • hCDK12 antibody
  • Pksc antibody

Protein level used designations for CRKRS

CG7597-PA , CG7597-PB , CG7597-PC , Cdk12-PA , Cdk12-PB , Cdk12-PC , Cdc2-related kinase, arginine/serine-rich , CDC2-related protein kinase 7 , cell division cycle 2-related protein kinase 7 , cell division protein kinase 12 , CDC2-related kinase 7 , CDC2-related kinase, arginine/serine-rich , protein kinase for splicing component , cyclin-dependent kinase 12 isoform , cyclin-dependent kinase 12 , Cell division protein kinase 12

GENE ID SPECIES
40385 Drosophila melanogaster
100354313 Oryctolagus cuniculus
51755 Homo sapiens
69131 Mus musculus
192350 Rattus norvegicus
511513 Bos taurus
100467815 Ailuropoda melanoleuca
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