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Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Additionally we are shipping CADM1 Proteins (14) and CADM1 Kits (7) and many more products for this protein.
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Human Polyclonal CADM1 Primary Antibody for EIA, IHC (p) - ABIN951001
McGovern, Jones, Taylor, Marciante, Yan, Dubinsky, Ippoliti, Vasiliauskas, Berel, Derkowski, Dutridge, Fleshner, Shih, Melmed, Mengesha, King, Pressman, Haritunians, Guo, Targan, Rotter: Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. in Human molecular genetics 2010
Show all 5 references for ABIN951001
Human Polyclonal CADM1 Primary Antibody for IF (p), IHC (p) - ABIN738351
Liu, Cui, Ao, Zhou, Zhou, Yuan, Xiang, Liu, Cao et al.: Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of ... in Toxicology and applied pharmacology 2011
Show all 2 references for ABIN738351
Human Polyclonal CADM1 Primary Antibody for IHC (p), WB - ABIN654660
Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: An approach based on a genome-wide association study reveals candidate loci for narcolepsy. in Human genetics 2010
Human Polyclonal CADM1 Primary Antibody for IHC, ELISA - ABIN1585332
Ballester, Gonin, Rodenas, Bernaudin, Rouzier, Coutant, Daraï: Eutopic endometrium and peritoneal, ovarian and colorectal endometriotic tissues express a different profile of nectin-1, -3, -4 and nectin-like molecule 2. in Human reproduction (Oxford, England) 2012
Decreased expression of TSLC1 is correlated with the malignancy of non-muscle invasive bladder cancer tissues and low TSLC1 expression may serve as a predictor for bladder cancer recurrence and progression.
CADM1 deletion is associated with neuroblastoma (show ARHGEF16 Antibodies) and ganglioneuroma.
Hypermethylation of CADM1 gene may be highly associated with the development of cervical cancer.
Our study showed that miR (show MLXIP Antibodies)-126, by down-regulation CADM1, enhances migration and invasion in gastric cancer cells.
This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL (show MAL Antibodies) than Merkel cell polyomavirus -positive Merkel cell carcinomas
CADM1/MAL (show MAL Antibodies) methylation increases with severity of cervical intraepithelial neoplasia
SynCAM1 delineates the postsynaptic perimeter of the synaptic cleft as determined by immunoelectron microscopy.
increased CADM1 shedding appeared to contribute to the development of emphysema by generating alphaCTF and the ICD in lung epithelial cells.
CADM1 shedding is increased in idiopathic interstitial pneumonia and contributes to alveolar epithelial cell apoptosis.
a central role of CADM1 in stabilizing the complex with 4.1B (show EPB41L3 Antibodies) and MPP3 (show MPP3 Antibodies)
This experiments show that the survival rate of adult-generated neurons is increased by overexpressing SynCAM 1
Our study reveals a novel mechanism of chronic NF-kappaB (show NFKB1 Antibodies) activation by CADM1 in HTLV-1 infected cells
Study demonstrates that polysialic acid-SynCAM 1 defines a subpopulation of NG2 (show Vcan Antibodies) cells and identifies the presence of polysialic acid-NRP2 (show NRP2 Antibodies) in microglia
CADM1 appeared to sustain gap junctional intercellular communication among alpha-cells via homophilic binding and, based on this action, CADM1 appears to prevent excessive secretion of glucagon (show GCG Antibodies) from alpha-cells.
This study demonistrated that SynCAM 1 in the synaptic organization of the rod visual pathway and provide evidence for novel roles of synaptic adhesion in the structural and functional integrity of ribbon synapses.
Necl-2 co-localizes with ErbB4 (show ERBB4 Antibodies) in hippocampus and and regulates ErbB4 (show ERBB4 Antibodies) signaling in cultured neurons.
TGF-beta1 is a potent cytokine that provides an effective mechanism in controlling Necl-2 expression in the testis via Smad-dependent gene repression and clathrin-mediated endocytosis.
Loss of SynCAM1 modulates cocaine effects on spine structures in the nucleus accumbens.
The bone volume fraction did not differ between the CADM1 knockout mice and the wild type mice for both 8-week old and 11-week old mice.
Cadm1 is indeed a bona fide tumor suppressor gene and provide new insights into genetic partners that co-operate in tumorigenesis when Cadm1-expression is lost.
Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
immunoglobulin superfamily, member 4
, cell adhesion molecule 1
, TSLC1/Nectin-like 2/IGSF4
, immunoglobulin superfamily member 4
, immunoglobulin superfamily, member 4D variant 1
, immunoglobulin superfamily, member 4D variant 2
, nectin-like 2
, nectin-like protein 2
, spermatogenic immunoglobulin superfamily
, synaptic cell adhesion molecule
, truncated CADM1 protein
, tumor suppressor in lung cancer 1
, cell adhesion molecule 1 transcript variant 8abc
, immunoglobulin superfamily member 4A
, immunosuperfamily protein Bl2
, immunoglobulin superfamily, member 4A
, secretory isoform of TSLC1