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Cell Adhesion Molecule 1 Proteins (CADM1)

Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Additionally we are shipping CADM1 Antibodies (110) and CADM1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CADM1 CADM1 445438  
CADM1 23705 Q9BY67
CADM1 54725 Q8R5M8
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Top CADM1 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_HEK-293 Human His tag 50 μg Log in to see 2 to 3 Days
$630.00
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details
HOST_Human Mouse Fc Tag   10 μg Log in to see 5 Days
$143.00
Details

CADM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, ,
Mouse (Murine) , , ,
, ,

Top referenced CADM1 Proteins

  1. Human CADM1 Protein expressed in Human Cells - ABIN2004040 : Boles, Barchet, Diacovo, Cella, Colonna: The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. in Blood 2005 (PubMed)
    Show all 5 references for ABIN2004040

  2. Human CADM1 Protein expressed in HEK-293 Cells - ABIN2180672 : Kuramochi, Fukuhara, Nobukuni, Kanbe, Maruyama, Ghosh, Pletcher, Isomura, Onizuka, Kitamura, Sekiya, Reeves, Murakami: TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. in Nature genetics 2001 (PubMed)
    Show all 5 references for ABIN2180672

  3. Human CADM1 Protein expressed in Wheat germ - ABIN1347851 : Hasstedt, Bezemer, Callas, Vossen, Trotman, Hebbel, Demers, Rosendaal, Bovill: Cell adhesion molecule 1: a novel risk factor for venous thrombosis. in Blood 2009 (PubMed)

More Proteins for Cell Adhesion Molecule 1 (CADM1) Interaction Partners

Human Cell Adhesion Molecule 1 (CADM1) interaction partners

  1. CADM1 deletion is associated with neuroblastoma (show ARHGEF16 Proteins) and ganglioneuroma.

  2. Hypermethylation of CADM1 gene may be highly associated with the development of cervical cancer.

  3. Our study showed that miR (show MLXIP Proteins)-126, by down-regulation CADM1, enhances migration and invasion in gastric cancer cells.

  4. This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL (show MAL Proteins) than Merkel cell polyomavirus -positive Merkel cell carcinomas

  5. CADM1/MAL (show MAL Proteins) methylation increases with severity of cervical intraepithelial neoplasia

  6. SynCAM1 delineates the postsynaptic perimeter of the synaptic cleft as determined by immunoelectron microscopy.

  7. increased CADM1 shedding appeared to contribute to the development of emphysema by generating alphaCTF and the ICD in lung epithelial cells.

  8. CADM1 shedding is increased in idiopathic interstitial pneumonia and contributes to alveolar epithelial cell apoptosis.

  9. a central role of CADM1 in stabilizing the complex with 4.1B (show EPB41L3 Proteins) and MPP3 (show MPP3 Proteins)

  10. Results show that CADM1 is downregulated in HPV-positive cervical cancers and that epigenetic alteration of CADM1 was more frequent in this type of cancer. The restoration of CADM1 expression may be a potential strategy for cervical cancer therapy.

Mouse (Murine) Cell Adhesion Molecule 1 (CADM1) interaction partners

  1. Our study reveals a novel mechanism of chronic NF-kappaB (show NFKB1 Proteins) activation by CADM1 in HTLV-1 infected cells

  2. Study demonstrates that polysialic acid-SynCAM 1 defines a subpopulation of NG2 (show Vcan Proteins) cells and identifies the presence of polysialic acid-NRP2 (show NRP2 Proteins) in microglia

  3. CADM1 appeared to sustain gap junctional intercellular communication among alpha-cells via homophilic binding and, based on this action, CADM1 appears to prevent excessive secretion of glucagon (show GCG Proteins) from alpha-cells.

  4. This study demonistrated that SynCAM 1 in the synaptic organization of the rod visual pathway and provide evidence for novel roles of synaptic adhesion in the structural and functional integrity of ribbon synapses.

  5. Necl-2 co-localizes with ErbB4 (show ERBB4 Proteins) in hippocampus and and regulates ErbB4 (show ERBB4 Proteins) signaling in cultured neurons.

  6. TGF-beta1 is a potent cytokine that provides an effective mechanism in controlling Necl-2 expression in the testis via Smad-dependent gene repression and clathrin-mediated endocytosis.

  7. Loss of SynCAM1 modulates cocaine effects on spine structures in the nucleus accumbens.

  8. The bone volume fraction did not differ between the CADM1 knockout mice and the wild type mice for both 8-week old and 11-week old mice.

  9. Cadm1 is indeed a bona fide tumor suppressor gene and provide new insights into genetic partners that co-operate in tumorigenesis when Cadm1-expression is lost.

  10. These results indicated that CADM1 was a novel osteoblastic adhesion molecule (show NCAM1 Proteins) that is expressed transiently during osteoblastic maturation, and a useful diagnostic marker for osteosarcoma cells.

CADM1 Protein Profile

Protein Summary

Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Gene names and symbols associated with CADM1

  • cell adhesion molecule 1 (CADM1)
  • cell adhesion molecule 1 (LOC100354915)
  • immunoglobulin superfamily, member 4 (IGSF4)
  • cell adhesion molecule 1 (cadm1)
  • cell adhesion molecule 1 (Cadm1)
  • 2900073G06Rik protein
  • 3100001I08Rik protein
  • AI987920 protein
  • Bl2 protein
  • Igsf4 protein
  • Igsf4a protein
  • Necl-2 protein
  • Necl2 protein
  • RA175 protein
  • RA175A protein
  • RA175B protein
  • RA175C protein
  • RA175N protein
  • SgIGSF protein
  • ST17 protein
  • sTSLC-1 protein
  • SynCam protein
  • synCAM1 protein
  • Tslc1 protein
  • xnecl2 protein

Protein level used designations for CADM1

immunoglobulin superfamily, member 4 , cell adhesion molecule 1 , TSLC-1 , TSLC1/Nectin-like 2/IGSF4 , immunoglobulin superfamily member 4 , immunoglobulin superfamily, member 4D variant 1 , immunoglobulin superfamily, member 4D variant 2 , nectin-like 2 , nectin-like protein 2 , spermatogenic immunoglobulin superfamily , synaptic cell adhesion molecule , truncated CADM1 protein , tumor suppressor in lung cancer 1 , NECL-2 , cell adhesion molecule 1 transcript variant 8abc , immunoglobulin superfamily member 4A , immunosuperfamily protein Bl2 , immunoglobulin superfamily, member 4A , secretory isoform of TSLC1

GENE ID SPECIES
529873 Bos taurus
100354915 Oryctolagus cuniculus
445438 Rattus norvegicus
735231 Xenopus laevis
23705 Homo sapiens
54725 Mus musculus
363058 Rattus norvegicus
479432 Canis lupus familiaris
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