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CDON encodes a cell surface receptor that is a member of the immunoglobulin superfamily. Additionally we are shipping Cell Adhesion Molecule-Related/down-Regulated By Oncogenes Proteins (8) and Cell Adhesion Molecule-Related/down-Regulated By Oncogenes Kits (4) and many more products for this protein.
Showing 10 out of 56 products:
Human Polyclonal CDON Primary Antibody for ELISA - ABIN1999437
Wegorzewska, Krauss, Kang: Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD. in Molecular carcinogenesis 2003
Show all 2 references for ABIN1999437
Cow (Bovine) Polyclonal CDON Primary Antibody for ELISA, ICC - ABIN4297093
Kang, Feinleib, Knox, Ketteringham, Krauss: Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2003
Cdon is required to localize N-cadherin (show CDH2 Antibodies) to the cell membrane in migratory neural crest cells for directed migration.
In the developing optic vesicle, Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hedgehog (show SHH Antibodies) protein, thereby limiting its dispersion.
We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis
CDO (show CDO1 Antibodies) is required for proliferation and survival of lung cancer cells via Hh signaling.
These data support the view that cell-adhesion molecule (show MCAM Antibodies)-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs.
Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer.
Mutations in the CDON cause holoprosencephaly. (Review)
We found that CDON is overexpressed in prostate cancer
CDON must associate with both ligand and other hedgehog (show SHH Antibodies)-receptor components, particularly PTCH1 (show PTCH1 Antibodies), for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly.
Hedgehog (show SHH Antibodies) proteins interact with cell adhesion molecule (show MCAM Antibodies), down-regulated by oncogenes (CDO (show CDO1 Antibodies)) and brother of CDO (BOC (show BOC Antibodies)) in a conserved manner
CDO (show CDO1 Antibodies) and BOC (show BOC Antibodies) play a role in differentiation of cells in the skeletal muscle lineage
CDO (show CDO1 Antibodies) and BOC (show BOC Antibodies) forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact.
Suggest that Cdo (show CDO1 Antibodies) is required for the full Shh (show SHH Antibodies) signaling activation to induce efficient dopaminergic neuron neurogenesis.
Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1 (show PTCH1 Antibodies).
Cx43 (show GJA1 Antibodies) physically interacts with Cdo (show CDO1 Antibodies) to form dynamic complexes during myoblast differentiation
Stim1 (show STIM1 Antibodies) protein levels were decreased in Cdo (show CDO1 Antibodies)-deficient perinatal hindlimb muscles or primary myoblasts; this correlates with defective NFATc3 (show NFATC3 Antibodies) activation in Cdo (show CDO1 Antibodies)(-/-) myoblasts upon differentiation.
ASK1 (show MAP3K5 Antibodies) and TAK1 (show NR2C2 Antibodies) function as MAP3 kinases in Cdo (show CDO1 Antibodies)-mediated p38MAPK (show MAPK14 Antibodies) activation to promote myogenic differentiation.
Gas1 (show GAS1 Antibodies) cooperates with Cdo (show CDO1 Antibodies) and promotes myogenic differentiation via activation of p38MAPK (show MAPK14 Antibodies)
the Integrin/FAK (show PTK2 Antibodies) signaling pathway regulates the expression of the promyogenic factors, Cdo (show CDO1 Antibodies), MyoD (show MYOD1 Antibodies) and Cdc42 (show CDC42 Antibodies) which are required for myoblast differentiation
Cdo (show CDO1 Antibodies);Boc (show BOC Antibodies) double mutants on a largely Cdo (show CDO1 Antibodies)-resistant genetic background have lobar holoprosencephaly.
The promyogenic function of Cdo (show CDO1 Antibodies) involves a coordinated activation of p38MAPK (show MAPK14 Antibodies) and Akt (show AKT1 Antibodies) via association with scaffold proteins, JLP (show SPAG9 Antibodies) and Bnip-2 (show BNIP2 Antibodies) for p38MAPK (show MAPK14 Antibodies) and APPL1 (show APPL1 Antibodies) for Akt (show AKT1 Antibodies).
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis.
Cdon homolog (mouse)
, surface glycoprotein, Ig superfamily member
, cell adhesion molecule-related/down-regulated by oncogenes
, Cdon homolog
, immunoglobulin superfamily member
, CAM-related/down-regulated by oncogenes
, immunoglobulin superfamily member CDO
, oncogene-regulated cell adhesion molecule
, cysteine dioxygenase type 1
, cysteine dioxygenase type I