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CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. Additionally we are shipping CDC20 Antibodies (218) and CDC20 Proteins (7) and many more products for this protein.
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The ABBA-KEN (show PCNT ELISA Kits)-ABBA amino acid motif cassette holds the Mitotic Checkpoint (show BUB3 ELISA Kits) Complex (MCC) onto the Anaphase-Promoting Complex-Cyclosome (APC (show APC ELISA Kits)/C) by binding the two Cdc20 molecules in the MCC-APC (show APC ELISA Kits)/C complex.
It discuses the roles of Cdc20 in SAC (show ADCY10 ELISA Kits) signalling and mitotic exit, describe how the integration of traditional approaches with emerging technologies has revealed new details of Cdc20 functions, comment about the potential of Cdc20 as a therapeutic target for the treatment of human malignancies.
Prostate cancer-derived SPOP (show SPOP ELISA Kits) mutants failed to interact with Cdc20 to promote its degradation. As a result, SPOP (show SPOP ELISA Kits)-deficient prostate cancer cells with elevated Cdc20 expression became resistant to a pharmacological Cdc20 inhibitor.
High CDC20 expression is associated with metastatic castration-resistant prostate cancer growth and reduces chemosensitivity .
These results provide novel insight into the mechanisms underlying the aberrant capability of NUP98 (show NUP98 ELISA Kits) oncoproteins to interact with APC (show APC ELISA Kits)/C(Cdc20) and to interfere with its function.
In lung adenocarcinoma patients, overexpression of cell division cycle 20 was significantly associated with bigger primary tumor size, higher MKI67 (show MKI67 ELISA Kits) level, higher DNA ploidy level, and poor prognosis.
CDC20 may have a role in carcinoma of the breast, colon, endometrium, and prostate
Overexpression of Cdc20 may serve as an independent predictor for biochemical recurrence in patients of clinically localized prostate cancer undergoing laparoscopic radical prostatectomy without neoadjuvant therapy.
Results show that CYP1B1 (show CYP1B1 ELISA Kits) may promote renal cell carcinoma development by inducing CDC20 expression and inhibiting apoptosis through the down-regulation of DAPK1 (show DAPK1 ELISA Kits).
Study describes a positive feedback loop centred on cyclin A2 (show CCNA2 ELISA Kits)-Cdk2 (show CDK2 ELISA Kits) inhibition of interphase APC (show APC ELISA Kits)/C-Cdc20 to allow further cyclin A2 (show CCNA2 ELISA Kits) accumulation and mitotic entry.
Cdc20 auto-ubiquitylation does not play a major role in terminating Cdc20 activation.
Dephosphorylation of Cdc20 is required for its loading and activation of the APC/C ubiquitin ligase.
A role for the fizzy/cdc20 family of proteins in activation of the APC (show APC ELISA Kits)/C distinct from substrate recruitment is reported.
Cdc20 hypomorphism causes chromatin bridging and chromosome misalignment, revealing a requirement for Cdc20 in efficient sister chromosome separation and chromosome-microtubule attachment.
The physiologically effective threshold level of Cdc20 is high for female meiosis I.
Results indicate that Cdc20 also contributes to post-anaphase activation of the APC (show APC ELISA Kits)/C.
The seven tandem WD motifs of Cdc20 they are required for speriolin binding and for localization of Cdc20 to the centrosomes and nucleus, suggesting that speriolin might regulate or stabilize the folding of Cdc20 during meiosis in spermatogenic cells
Data suggest that Mad2 (show MXI1 ELISA Kits) and BubR1 (show BUB1B ELISA Kits) must cooperate to inhibit Cdc20 activity.
Cdc20 is degraded through two independent degradation signals (degrons), the KEN (show PCNT ELISA Kits) box and a newly described CRY (show CRY2 ELISA Kits) box.
Cdc20 and securin (show PTTG1 ELISA Kits) double mutant embryos could not maintain the metaphase arrest, suggesting a role of securin (show PTTG1 ELISA Kits) in preventing mitotic exit
Expression of the cdc20 gene is down-regulated by zif268 (show EGR1 ELISA Kits) in neuronal cells; altered expression of proteasome-regulatory genes following zif268 (show EGR1 ELISA Kits) induction may be a key component of long-lasting CNS plasticity.
Cdc20 is required for the anaphase onset of the first meiosis but not the second meiosis in mouse oocytes
findings suggest a novel function of HSF1 (show HSF1 ELISA Kits) frequently overexpressed in cancer cells, to inhibit APC (show APC ELISA Kits)/C activity by interacting with Cdc20, and to result in aneuploidy development and genomic instability
porcine FZR1 and CDC20 work on the maintenance of meiotic arrest at the first meiotic prophase and on the exit from M1
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation.
cell division cycle 20 homolog
, CDC20 cell division cycle 20 homolog
, cell division cycle protein 20 homolog
, cell cycle protein p55CDC