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The protein encoded by CDC27 shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. Additionally we are shipping CDC27 Antibodies (137) and and many more products for this protein.
Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system.
Cdc27 is a novel binding partner of Elmo1 (show ELMO1 ELISA Kits).Cdc27-Elmo1 (show ELMO1 ELISA Kits) has a cellular role independent from the Elmo-Dock1 (show DOCK1 ELISA Kits)-Rac (show AKT1 ELISA Kits) signal module.
miR (show MLXIP ELISA Kits)-27a could modulate proliferation and radiosensitivity of TNBC cells. CDC-27 is a direct target of miR (show MLXIP ELISA Kits)-27a and its downregulation conferred increased radioresistance of the cells.
These findings suggested that polymorphisms in cdc27 may contribute to the susceptibility of BC though functional studies are needed to further elucidate the underling mechanisms of the associations
The structures show how one APC16 (show ANAPC16 ELISA Kits) binds asymmetrically to the symmetric APC3 dimer and, together with biochemistry and prior data, explain how APC16 (show ANAPC16 ELISA Kits) recruits APC7 (show ANAPC7 ELISA Kits) to APC3.
Low cdc27 and high securin (show PTTG1 ELISA Kits) expression predict short survival for breast cancer patients.
Down-regulation of CDC27 protein is associated with radiation resistance.
Data indicate that additional density present in the anaphase-promoting complex (APC (show APC ELISA Kits)/C) structure, proximal to Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to the TPR subunit Apc7 (show ANAPC7 ELISA Kits), a subunit specific to vertebrate APC (show APC ELISA Kits)/C.
the biochemical, structural, and cellular determinants of the novel interaction between MCPH1 (show MCPH1 ELISA Kits) and Cdc27 and suggest that this interaction may occur within the larger context of MCPH1 (show MCPH1 ELISA Kits)-APC (show APC ELISA Kits)/C.
phosphorylation of Cdc27 by CKII (show CSNK2A1 ELISA Kits) is involved in TGF-beta (show TGFB1 ELISA Kits)-induced activation of APC (show APC ELISA Kits).
Cdc27 directs cyclin D1 (show CCND1 ELISA Kits) to alternative degradation by anaphase promoting complex/cyclosome.
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
cell division cycle 27 homolog (S. cerevisiae)
, cell division cycle 27 homolog
, cell division cycle protein 27 homolog
, CDC27 homolog
, anaphase promoting complex subunit 3
, anaphase-promoting complex subunit 3
, anaphase-promoting complex, protein 3
, nuc2 homolog