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Cell Division Cycle 37 Homolog (S. Cerevisiae) Proteins (CDC37)

The protein encoded by CDC37 is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. Additionally we are shipping CDC37 Antibodies (124) and CDC37 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CDC37 11140 Q16543
CDC37 12539 Q61081
Rat CDC37 CDC37 114562 Q63692
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Top CDC37 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human GST tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Baculovirus infected Insect Cells Mouse His tag,GST tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 3 to 4 Days
$411.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,045.17
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,085.50
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$3,312.83
Details

CDC37 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine) ,
,

Top referenced CDC37 Proteins

  1. Human CDC37 Protein expressed in Escherichia coli (E. coli) - ABIN666715 : Abbas-Terki, Briand, Donzé, Picard: The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically. in Biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN666715

  2. Human CDC37 Protein expressed in Baculovirus infected Insect Cells - ABIN2003178 : Roiniotis, Masendycz, Ho, Scholz: Domain-mediated dimerization of the Hsp90 cochaperones Harc and Cdc37. in Biochemistry 2005 (PubMed)
    Show all 2 references for ABIN2003178

  3. Human CDC37 Protein expressed in Escherichia coli (E. coli) - ABIN1686724 : Dai, Kobayashi, Beach: Physical interaction of mammalian CDC37 with CDK4. in The Journal of biological chemistry 1996 (PubMed)

More Proteins for Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) Interaction Partners

Fruit Fly (Drosophila melanogaster) Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) interaction partners

Human Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) interaction partners

  1. Apart from these distinct Cdc37/Hsp90 interfaces, binding of the B-Raf protein kinase to the cochaperone is conserved between mammals and nematodes.

  2. Suppressing expression of the cochaperone CDC37 in hepatocellular carcinoma cells inhibits cell cycle progression and cell growth.

  3. RIP3 (show RIPK3 Proteins) activation following the induction of necroptosis requires the activity of an HSP90 (show HSP90 Proteins) and CDC37 cochaperone complex.

  4. Correlation between PDZK1 (show PDZK1 Proteins), Cdc37, Akt (show AKT1 Proteins) and breast cancer malignancy: the role of PDZK1 (show PDZK1 Proteins) in cell growth through Akt (show AKT1 Proteins) stabilization by increasing and interacting with Cdc37

  5. The N-terminal tail serves as an intramolecular chaperone ensuring that CDC37 assumes one of two interconvertible states in a manner impacting the interaction of the client binding N-domain and the MC-domains, involved in dimerization and HSP90 (show HSP90 Proteins) binding.

  6. CDC37 has an important role in chaperoning protein kinases; it stabilizes kinase clients by a mechanism that is not dependent on a substantial direct interaction between CDC37 and HSP90 (show HSP90 Proteins), but requires HSP90 (show HSP90 Proteins) activity

  7. As a novel Hsp90 (show HSP90 Proteins) inhibitor, FW-04-806 binds to the N-terminal of Hsp90 (show HSP90 Proteins) and inhibits Hsp90 (show HSP90 Proteins)/Cdc37 interaction, resulting in the disassociation of Hsp90 (show HSP90 Proteins)/Cdc37/client complexes and the degradation of Hsp90 (show HSP90 Proteins) client proteins.

  8. CDC37 is a crucial HSP90 (show HSP90 Proteins)-cofactor for KIT oncogenic expression in gastrointestinal stromal tumors

  9. SGK3 (show SGK3 Proteins) stability and kinase activation are regulated by the Hsp90 (show HSP90 Proteins)-Cdc37 chaperone complex.

  10. Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90 (show HSP90 Proteins)) motility by interaction with N-terminal and middle domain binding sites.

Mouse (Murine) Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) interaction partners

  1. A series of tyrosine phosphorylation events, involving both p50(Cdc37) and Hsp90 (show HSP90 Proteins), are minimally sufficient to provide directionality to the chaperone cycle.

  2. Hsp90 (show HSP90 Proteins)-Cdc37 complex acta (show ACTC1 Proteins) as an endogenous regulator of noncanonical p38alpha (show MAPK14 Proteins) activity.

  3. CDC37 binds to Akt (show AKT1 Proteins) and HSP90 (show HSP90 Proteins) in the signal transduction pathway in human tumor cells

  4. The interaction between mouse Pem and Cdc37 homolog was then confirmed by glutathione S-transferase (show GSTa2 Proteins) pull-down assay, and the possible interaction model was suggested.

  5. JAK1 (show JAK1 Proteins)/2 are client proteins of Hsp90 alpha (show HSP90AA1 Proteins) and beta; Hsp90 (show HSP90 Proteins) and CDC37 play a critical role in types I and II interferon (show IFNA Proteins) pathways

  6. This growth inhibition is partially rescued by expression of ectopic Gli1 (show GLI1 Proteins), suggesting that Fu may contribute to enhance Hh signaling activity in cancer cells.

Cow (Bovine) Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) interaction partners

  1. Cdc37 has a direct regulatory interaction with endothelial nitric oxide synthase (eNOS (show NOS3 Proteins)) and may play an important role in mediating the eNOS (show NOS3 Proteins) protein complex formation.

CDC37 Protein Profile

Protein Summary

The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.

Gene names and symbols associated with CDC37

  • CG12019 gene product from transcript CG12019-RA (Cdc37)
  • cell division cycle 37 homolog (Cdc37)
  • Hsp90 co-chaperone Cdc37 (cdc37)
  • Hsp90 co-chaperone Cdc37 (AFUA_4G10010)
  • Cell cycle protein necessary for passage of START (CDC37)
  • cell division cycle 37 (CDC37)
  • cell division cycle 37 (Cdc37)
  • cell division cycle 37 homolog (S. cerevisiae) (CDC37)
  • Afu4g10010 protein
  • cdc37 protein
  • CG12019 protein
  • CPDR-1 protein
  • CPDR-2 protein
  • Dmel\\CG12019 protein
  • DROCPDR protein
  • E(sev)3B protein
  • p50 protein
  • p50Cdc37 protein

Protein level used designations for CDC37

CG12019-PA , Cdc37-PA , cdc37 protein , hsp90 co-chaperone Cdc37 , Hsp90 co-chaperone Cdc37 , hypothetical protein , CDC37 (cell division cycle 37, S. cerevisiae, homolog) , CDC37 cell division cycle 37 homolog , cell division cycle 37 homolog , hsp90 chaperone protein kinase-targeting subunit , CDC37 (cell division cycle 37 S. cerevisiae homolog) , p50Cdc37 , CDC37 cell division cycle 37 protein , CDC37 homolog , cell division cycle 37 protein , cell division cycle control protein 37

GENE ID SPECIES
38232 Drosophila melanogaster
724675 Apis mellifera
2541293 Schizosaccharomyces pombe 972h-
3509722 Aspergillus fumigatus Af293
3639210 Candida albicans SC5314
11140 Homo sapiens
12539 Mus musculus
114562 Rattus norvegicus
484955 Canis lupus familiaris
100141402 Sus scrofa
520883 Bos taurus
395430 Gallus gallus
Selected quality suppliers for CDC37 Proteins (CDC37)
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