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CDC73 encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. Additionally we are shipping Cell Division Cycle 73, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) Proteins (7) and many more products for this protein.
Showing 10 out of 57 products:
Human Polyclonal CDC73 Primary Antibody for FACS, IF - ABIN653128
Vierimaa, Villablanca, Alimov, Georgitsi, Raitila, Vahteristo, Larsson, Ruokonen, Eloranta, Ebeling, Ignatius, Aaltonen, Leisti, Salmela: Mutation analysis of MEN1, HRPT2, CASR, CDKN1B, and AIP genes in primary hyperparathyroidism patients with features of genetic predisposition. in Journal of endocrinological investigation 2009
Data showed that the N-terminus of Hyx-Wt-HA was exclusively acetylated whereas the amino terminus of Hyx-A2P-HA always remained unmodified.
Data show that Drosophila Hyrax and its human ortholog, Parafibromin, are required for nuclear transduction of the Wnt/Wg signal and bind directly to the C-terminal region of beta-catenin/Armadillo.
These results suggest a target gene-selective involvement of the PAF1 (show PAF1 Antibodies) complex in Hh signaling via the Parafibromin/Hyx-mediated recruitment to Gli (show GLI1 Antibodies)/Ci.
These findings suggest that downregulated expression of parafibromin protein plays an important role in the pathogenesis, differentiation, and metastasis of head and neck squamous cell carcinomas
Parafibromin interacted with JAK1 (show JAK1 Antibodies)/2, promoted the interactions of JAK1 (show JAK1 Antibodies)-JAK2 (show JAK2 Antibodies) and JAK1 (show JAK1 Antibodies)/2-STAT1 (show STAT1 Antibodies), and promoted tyrosine phosphorylation of STAT1 (show STAT1 Antibodies) by JAKs after IFN-gamma (show IFNG Antibodies) stimulation.
targets and destabilizes p53 (show TP53 Antibodies) mRNA to control p53 (show TP53 Antibodies)-mediated apoptosis
Data report a novel mutation in the CDC73 gene that may underlie HPT-JT syndrome.
gene expression profiling experiments suggest that upregulated FGFR1 (show FGFR1 Antibodies) expression appears to be associated with parathyroid carcinoma in HPT-JT syndrome due to an HRPT2 splicing mutation
A previously unreported intragenic deletion of exons 1 to 10 of CDC73 was detected in a three-generation family with familial primary hyperparathyroidism with parathyroid carcinoma.
Mutations within the nucleolar localisation signals of the CDC73 gene led to instability either of the corresponding mutated protein or mRNA or both.
Negative parafibromin staining is associated with malignant behavior in atypical parathyroid adenomas.
Genetic analysis of a patient with hyperparathyroidism-jaw tumor revealed a novel nonsense mutation in exon 1 of CDC73
Data indicate that overexpression of Wilms tumor 1 (show WT1 Antibodies) gene (WT1 (show WT1 Antibodies)) decreased CDC73 levels and promoted proliferation of oral squamous cell carcinoma (OSCC) cells.
Data indicate that isruption of the MLL (show MLL Antibodies)-PAFc subunit, Cdc73 (Hrpt2) interaction selectively inhibits the proliferation of MLL (show MLL Antibodies) leukemic cells.
Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation
Expression of Hrpt2 and parafibromin is pivotal in mammalian development and survival in adults and that these functions are likely mediated by the transcriptional regulation of growth factors.
This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma.
, CDC37 cell division cycle 37 homolog
, cell division cycle 37 homolog
, hsp90 co-chaperone Cdc37
, hyperparathyroidism 2 homolog
, Paf1/RNA polymerase II complex component
, cell division cycle 73, Paf1/RNA polymerase II complex component, homolog
, cell division cycle protein 73 homolog
, hyperparathyroidism 2 protein
, hyperparathyroidism 2 (with jaw tumor)
, hyperparathyroidism 2 protein homolog
, Vcell division cycle 73, Paf1/RNA polymerase II complex component, homolog
, hyperparathyroidism 2 with jaw tumor protein