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Cell Division Cycle 73, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) Proteins (CDC73)

CDC73 encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. Additionally we are shipping Cell Division Cycle 73, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) Antibodies (57) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CDC73 79577 Q6P1J9
CDC73 304832 Q4V8C8
CDC73 214498 Q8JZM7
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Top Cell Division Cycle 73, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$3,017.67
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Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,510.83
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$385.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CDC73 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Cell Division Cycle 73, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (CDC73) Interaction Partners

Fruit Fly (Drosophila melanogaster) Cell Division Cycle 73, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (CDC73) interaction partners

  1. Data showed that the N-terminus of Hyx-Wt-HA was exclusively acetylated whereas the amino terminus of Hyx-A2P-HA always remained unmodified.

  2. Data show that Drosophila Hyrax and its human ortholog, Parafibromin, are required for nuclear transduction of the Wnt/Wg signal and bind directly to the C-terminal region of beta-catenin/Armadillo.

  3. These results suggest a target gene-selective involvement of the PAF1 (show PAF1 Proteins) complex in Hh signaling via the Parafibromin/Hyx-mediated recruitment to Gli (show GLI1 Proteins)/Ci.

Human Cell Division Cycle 73, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (CDC73) interaction partners

  1. These findings suggest that downregulated expression of parafibromin protein plays an important role in the pathogenesis, differentiation, and metastasis of head and neck squamous cell carcinomas

  2. Parafibromin interacted with JAK1 (show JAK1 Proteins)/2, promoted the interactions of JAK1 (show JAK1 Proteins)-JAK2 (show JAK2 Proteins) and JAK1 (show JAK1 Proteins)/2-STAT1 (show STAT1 Proteins), and promoted tyrosine phosphorylation of STAT1 (show STAT1 Proteins) by JAKs after IFN-gamma (show IFNG Proteins) stimulation.

  3. targets and destabilizes p53 (show TP53 Proteins) mRNA to control p53 (show TP53 Proteins)-mediated apoptosis

  4. Data report a novel mutation in the CDC73 gene that may underlie HPT-JT syndrome.

  5. gene expression profiling experiments suggest that upregulated FGFR1 (show FGFR1 Proteins) expression appears to be associated with parathyroid carcinoma in HPT-JT syndrome due to an HRPT2 splicing mutation

  6. A previously unreported intragenic deletion of exons 1 to 10 of CDC73 was detected in a three-generation family with familial primary hyperparathyroidism with parathyroid carcinoma.

  7. Mutations within the nucleolar localisation signals of the CDC73 gene led to instability either of the corresponding mutated protein or mRNA or both.

  8. Negative parafibromin staining is associated with malignant behavior in atypical parathyroid adenomas.

  9. Genetic analysis of a patient with hyperparathyroidism-jaw tumor revealed a novel nonsense mutation in exon 1 of CDC73

  10. Data indicate that overexpression of Wilms tumor 1 (show WT1 Proteins) gene (WT1 (show WT1 Proteins)) decreased CDC73 levels and promoted proliferation of oral squamous cell carcinoma (OSCC) cells.

Mouse (Murine) Cell Division Cycle 73, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (CDC73) interaction partners

  1. Data indicate that isruption of the MLL (show MLL Proteins)-PAFc subunit, Cdc73 (Hrpt2) interaction selectively inhibits the proliferation of MLL (show MLL Proteins) leukemic cells.

  2. Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation

  3. Expression of Hrpt2 and parafibromin is pivotal in mammalian development and survival in adults and that these functions are likely mediated by the transcriptional regulation of growth factors.

Cell Division Cycle 73, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (CDC73) Protein Profile

Protein Summary

This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma.

Gene names and symbols associated with CDC73

  • hyrax (hyx)
  • CDC37 cell division cycle 37 homolog (S. cerevisiae) (cdc37)
  • cell division cycle 37 (cdc37)
  • hyperparathyroidism 2 (with jaw tumor) (hrpt2)
  • parafibromin (Tsp_03925)
  • parafibromin (Tsp_04052)
  • parafibromin (Tsp_04125)
  • cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) (CDC73)
  • Parafibromin (cdc73)
  • parafibromin (LOC100222932)
  • parafibromin (LOC100348258)
  • cell division cycle 73 (CDC73)
  • cell division cycle 73 (Cdc73)
  • cell division cycle 73, Paf1/RNA polymerase II complex component (Cdc73)
  • cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) (cdc73)
  • 8430414L16Rik protein
  • BC027756 protein
  • C1orf28 protein
  • C81219 protein
  • C130030P16Rik protein
  • cdc37 protein
  • cdc73 protein
  • CG11990 protein
  • Dmel\\CG11990 protein
  • HPTJT protein
  • Hrpt2 protein
  • HYX protein
  • hyx/CDC73 protein
  • LOC100222932 protein
  • MGC52623 protein
  • MGC108428 protein
  • zgc:63956 protein

Protein level used designations for CDC73

CG11990-PA , CG11990-PB , hyx-PA , hyx-PB , parafibromin , CDC37 cell division cycle 37 homolog , cell division cycle 37 homolog , hsp90 co-chaperone Cdc37 , hyperparathyroidism 2 homolog , Parafibromin , Paf1/RNA polymerase II complex component , cell division cycle 73, Paf1/RNA polymerase II complex component, homolog , cell division cycle protein 73 homolog , hyperparathyroidism 2 protein , hyperparathyroidism 2 (with jaw tumor) , hyperparathyroidism 2 protein homolog , Vcell division cycle 73, Paf1/RNA polymerase II complex component, homolog , hyperparathyroidism 2 with jaw tumor protein , sun , sunrise

GENE ID SPECIES
41086 Drosophila melanogaster
379968 Xenopus laevis
548666 Xenopus (Silurana) tropicalis
548785 Xenopus (Silurana) tropicalis
10904016 Trichinella spiralis
10904471 Trichinella spiralis
10904708 Trichinella spiralis
100139547 Bos taurus
100196612 Salmo salar
100222932 Taeniopygia guttata
100348258 Oryctolagus cuniculus
79577 Homo sapiens
304832 Rattus norvegicus
214498 Mus musculus
424356 Gallus gallus
478955 Canis lupus familiaris
393319 Danio rerio
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