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Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Additionally we are shipping and many more products for this protein.
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Human Polyclonal CDCA2 Primary Antibody for ELISA, WB - ABIN1534321
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
Human Polyclonal CDCA2 Primary Antibody for ICC, IF - ABIN4296986
Qian, Beullens, Huang, De Munter, Lesage, Bollen: Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch. in Nature communications 2015
Results report that BubR1 (show BUB1B Antibodies) and RepoMan bind directly to PP2A (show PPP2R4 Antibodies)-B56 using an LSPIxE short linear motif (SLiM), where phosphorylation of the Ser (show SIGLEC1 Antibodies) residue enhances binding. RepoMan and BubR1 (show BUB1B Antibodies) bind B56 using both hydrophobic and electrostatic interactions.
Aurora B (show AURKB Antibodies) phosphorylates Repo-Man at S893, preventing its recruitment by histones.
Data indicate that CDCA2 frequently is overexpressed in oral squamous cell carcinoma (OSCC) and might be associated with OSCC progression by preventing cell-cycle arrest and apoptosis.
It was shown that Repo-Man and Sds22 (show PPP1R7 Antibodies) contribute to timely Aurora B kinase (show AURKB Antibodies) substrate dephosphorylation on anaphase chromatin.
This study demonistrated that identify Repo-Man as a key factor that coordinates chromatin remodeling and early events of nuclear envelope reformation during mitotic exit.
Repo-Man promotes H3T11ph dephosphorylation by an indirect mechanism but directly and specifically targets H3T3ph for dephosphorylation by associated PP1gamma.
This study reports essential DNA damage response regulation mediated by Repo-Man-protein phosphatase 1 (show PPP1CB Antibodies) and further delineate underlying mechanisms.
Repo-Man forms an essential complex with protein phosphatase 1 (show PPP1CB Antibodies) (PP1 (show PPA1 Antibodies)) gamma and is required for the recruitment of PP1 (show PPA1 Antibodies) to chromatin
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity).
cell division cycle associated 2
, cell division cycle-associated protein 2
, protein phosphatase 1 [gamma] (PPP1R3A) binding protein Repo-Man
, recruits PP1 onto mitotic chromatin at anaphase protein