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Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. Additionally we are shipping Cell Division Cycle Associated 5 Proteins (4) and many more products for this protein.
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Human Polyclonal CDCA5 Primary Antibody for IHC - ABIN965837
Rankin, Ayad, Kirschner: Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. in Molecular cell 2005
Show all 2 references for ABIN965837
Human Polyclonal CDCA5 Primary Antibody for WB - ABIN2787615
Schmitz, Watrin, Lénárt, Mechtler, Peters: Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. in Current biology : CB 2007
the C-terminus of Sororin functions as an anchor binding to SA2 (show STAG2 Antibodies), which facilitates other conserved motifs on Sororin to interact with other proteins to regulate sister chromatid cohesion and separation.
We propose that the Prp19 (show PRPF19 Antibodies) complex and the splicing machinery contribute to the establishment of cohesion by promoting Sororin accumulation during S phase, and are, therefore, essential to the maintenance of genome stability.
A transcriptome-wide analysis revealed that SNW1 (show SNW1 Antibodies) or PRPF8 (show PRPF8 Antibodies) depletion affects the splicing of specific introns in a subset of pre-mRNAs, including pre-mRNAs encoding the cohesion protein sororin and the APC (show APC Antibodies)/C subunit APC2.
Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia.
Data show that the MEK (show MAP2K1 Antibodies)-ERK (show EPHB2 Antibodies) pathway regulates cell cycle-related neuronal apoptosis (CRNA) by elevating the levels of cyclin D1 (show CCND1 Antibodies), and the increase in cyclin D1 (show CCND1 Antibodies) attenuates the activation of cyclin-dependent kinase 5 (cdk5 (show CDK5 Antibodies)) by its neuronal activator p35 (show ANXA1 Antibodies).
Sororin is phosphorylated by Cdk1/cyclin B at prophase and acts as a docking protein to bring Plk1 into proximity with SA2, resulting in the phosphorylation of SA2 and the removal of cohesin complexes from chromosomal arms.
the interaction of the highly conserved motif at the C terminus of sororin with the cohesin complex (show SMC3 Antibodies) is critical to its ability to mediate sister chromatid cohesion.
Transactivation of CDCA5 and its phosphorylation at Ser209 by ERK (show EPHB2 Antibodies) play an important role in lung cancer proliferation.
data indicate that sororin interacts with chromatin-bound cohesin and functions during the establishment or maintenance of cohesion in S or G2 phase, respectively
Sororin protects centromeric cohesion in response to the spindle checkpoint, but prevents the removal of cohesion by a mechanism independent of the anaphase-promoting complex.
The authors show that sororin is essential for embryonic development, cohesion maintenance, and proper chromosome segregation.
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of wapal which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair (Probable).
cell division cycle associated 5
, cell division cycle-associated protein 5
, sororin p35
, cell division cycle-associated protein 5-A