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CDCA7 was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Additionally we are shipping CDCA7 Antibodies (29) and many more products for this protein.
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Missense mutations in CDCA7 cause immunodeficiency-centromeric instability-facial anomalies syndrome type 3.
Data indicate that cell division cycle associated 7 protein (show CDCA7L Proteins) (Cdca7) is strongly up-regulated in the hemogenic population during embryonic stem cell hematopoietic differentiation in a Notch (show NOTCH1 Proteins)-dependent manner.
The CDCA7 transcription factor regulates cell proliferation.
CDCA7 associates with MYC (show MYC Proteins) and this association is modulated in a phosphorylation-dependent manner.
JPO1/CDCA7 is a unique transcription regulator whose expression is activated by E2F1 (show E2F1 Proteins) as well as c-Myc (show MYC Proteins).
This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
cell division cycle associated 7
, cell division cycle associated protein 7
, cell division cycle-associated protein 7
, c-Myc target JPO1