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The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. Additionally we are shipping CREG1 Kits (13) and CREG1 Proteins (10) and many more products for this protein.
Showing 10 out of 62 products:
Human Polyclonal CREG1 Primary Antibody for EIA, WB - ABIN951699
Han, Wu, Deng, Tao, Guo, Tian, Kang, Zhang, Yan: Cellular repressor of E1A-stimulated genes inhibits human vascular smooth muscle cell apoptosis via blocking P38/JNK MAP kinase activation. in Journal of molecular and cellular cardiology 2010
Show all 5 references for ABIN951699
Cow (Bovine) Polyclonal CREG1 Primary Antibody for WB - ABIN2780552
Sacher, Di Bacco, Lunin, Ye, Wagner, Gill, Cygler: The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2005
Results indicate that cellular repressor of E1A (show BCKDHA Antibodies)-stimulated gene 1 protein (CREG1) increases endothelial cell (EC) filopodia formation.
The results suggest a novel role of CREG to promote HUVEC proliferation through the ERK (show EPHB2 Antibodies)/cyclin E (show CCNE1 Antibodies) signaling pathway.
CREG can inhibit NF-kappaB (show NFKB1 Antibodies) activation, TNF-alpha (show TNF Antibodies)-induced inflammatory responses and the hyperpermeability of endothelial cells.
miR (show MLXIP Antibodies)-31 not only directly binds to its target gene CREG and modulates the vascular smooth muscle cells(VSMC) phenotype through this interaction, but also can be an important biomarker in diseases involving VSMC phenotypic modulation.
Suggest that CREG is a novel adventitial fibroblast phenotypic modulator in a p38MAPK (show MAPK14 Antibodies)-dependent manner.
CREG plays a critical role in protecting the vascular endothelium from apoptosis, and the protective effort of CREG against ECs apoptosis is through the activation of the VEGF (show VEGFA Antibodies)/PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling pathway
Upregulation of CREG expression induced HUVEC migration.
Cooperation of CREG1 and p16 (INK4a (show CDKN2A Antibodies)) inhibits the expression of cyclin A (show CCNA2 Antibodies) and cyclin B by inhibiting promoter activity thereby decreasing mRNA and protein levels; these proteins are required for S-phase entry and G2/M transition.
Data suggest that soluble CREG protein can exert its biological function via glycosylation-independent binding to the extracellular domains 11-13 of cell surface M6P/IGF2R (show IGF2R Antibodies), modulating SMC (show DYM Antibodies) phenotypic switching from contractile to proliferative.
no ssociation between common variants of CREG and coronary artery disease in the northern Chinese Han population
CREG inhibits inflammation and promotes autophagy mediated by lysosome formation; it might be a potential therapeutic target in atherosclerosis.
CREG1 deficiency influenced the maturation of lysosomes and reduced the espression of Rab7 (show RAB7A Antibodies), which might be involved in CREG1-induced cardiomyocyte autophagy.
Data indicate cellular repressor of E1A (show BCKDHA Antibodies)-stimulated gene (CREG) as a factor in regulating endothelial differentiation and vasculogenesis via VEGF (show VEGFA Antibodies)/PI3K/Akt (show AKT1 Antibodies) pathway.
CREG plays a critical role in protecting the vascular endothelium from apoptosis, and the protective effort of CREG against ECs apoptosis is through the activation of the VEGF (show VEGFA Antibodies)/PI3K/AKT (show AKT1 Antibodies) signaling pathway
These results indicate that CREG is expressed during mouse embryogenesis and might participate in the differentiation of these organs during embryogenesis.
Results show that CREG is a lysosomal protein that undergoes proteolytic maturation during biosynthesis, carries the mannose 6-phosphate recognition marker and depends on the interaction with M-6-P receptors for efficient delivery to lysosomes.
Secreted Creg inhibits cell proliferation mediated by mannose-6-phosphate/insulin-like growth factor II receptor (show IGF2R Antibodies) in NIH 3T3 fibroblasts.
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.
cellular repressor of E1A-stimulated genes 1
, protein CREG1
, Protein CREG1
, hypothetical protein