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CNTROB encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Additionally we are shipping Centrobin, Centrosomal BRCA2 Interacting Protein Antibodies (57) and and many more products for this protein.
cytoplasmic centrobin has roles in noncentrosomal microtubule formation in specific cell types and during the cell cycle
Centrobin plays a role in the stability and centriole elongation function of CPAP (show CENPJ ELISA Kits) and limits the centriole length.
Centrobin-CPAP (show CENPJ ELISA Kits) interaction is critical for the recruitment of CPAP (show CENPJ ELISA Kits) to procentrioles to promote the elongation of daughter centrioles and for the persistence of CPAP (show CENPJ ELISA Kits) on preexisting mother centrioles.
it is proposed that Centrobin might regulate microtubule nucleation and organization by controlling the amount of pericentriolar matrix
NEK2 (show NEK2 ELISA Kits) phosphorylation antagonizes the microtubule stabilizing activity of centrobin.
Our results indicate that genetic polymorphisms of centrobin and Nek2 are related to breast cancer susceptibility in Chinese Han women.
Centrobin facilitates the elongation and stability of centrioles via its interaction with tubulins.
Data propose that centrobin functions as a microtubule stabilizing factor and PLK1 (show PLK1 ELISA Kits) enhances centrobin activity for proper spindle formation during mitosis.
a requirement of Centrobin in maintaining centrosome integrity, which in turn promotes anchoring of mitotic spindle to the centrosomes.
Inhibition of p38 (show CRK ELISA Kits) activity or downregulation of p38 (show CRK ELISA Kits) expression could overcome the cell-cycle arrest caused by centrobin depletion.
Centrobin may be a possible substrate of Nek2 (show NEK2 ELISA Kits) responsible for the meiotic spindle assembly in the mouse oocytes.
Data show that a residual amount of centrobin was detected at the centrosomes of the resting cells, suggesting its role for maintaining integrity of the centrosome, especially of the daughter centriole in the cells.
The phenotypic similarities of the Nip2/centrobin- and Nek2 (show NEK2 ELISA Kits)-suppressed embryos suggest that Nip2/centrobin may be a substrate of Nek2 (show NEK2 ELISA Kits) that is required for mitotic spindle assembly in early mouse embryos.
This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
centrobin, centrosomal BRCA2 interacting protein
, LYST-interacting protein LIP8
, LYST-interacting protein 8
, centrosomal BRCA2-interacting protein