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Centromere Protein F Proteins (CENPF)

CENPF encodes a protein that associates with the centromere-kinetochore complex. Additionally we are shipping CENPF Antibodies (54) and CENPF Kits (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse CENPF CENPF 108000  
Rat CENPF CENPF 257649  
CENPF 1063 P49454
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Top CENPF Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

CENPF Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Centromere Protein F (CENPF) Interaction Partners

Mouse (Murine) Centromere Protein F (CENPF) interaction partners

  1. FOXM1 (show FOXM1 Proteins) and CENPF are master regulators of prostate cancer malignancy, and can serve as drug response markers for antineoplastic drugs efficiency.

  2. Loss of CENP-F function in developing myocytes leads to decreased cell division, blunting of trabeculation and an initially smaller, thin-walled heart.

  3. These data demonstrate that CMF1 regulates myocyte differentiation by interaction with Rb family members to induce expression of myogenic regulatory factors.

  4. Data show that the post-anaphase, KEN-box-dependent degradation of Cenp-F requires it to be farnesylated, a post-translational modification usually linked to membrane association.

  5. Results identify Hook2 (show HOOK2 Proteins), a linker protein (show LAT Proteins) that is essential for regulation of the microtubule network at the centrosome, as a binding partner of CENP-F.

  6. LEK1 specifically functions during murine development to regulate the activity of Rb proteins during cell division and proliferation.

  7. These data suggest a role for LEK1 in regulating the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing cardiomyocytes.

  8. Results indicate that Raf (show RAF1 Proteins)-arrested myoblasts may serve as a model system for satellite cell cycle studies and that E2F5 and LEK1 translocation to the nucleus is an important first step during entry into quiescence.

  9. LEK1 plays a prominent role in regulating dendritic cell (DC) function for T cell activation, since knockdown of LEK1 expression results in the rapid maturation of Chlamydia-exposed DCs as measured by analysis of key activation markers.

  10. CENPF and syntaxin 4 (show STX4 Proteins) colocalize with components of plasma membrane recycling: SNAP-25 (show SNAP25 Proteins) and VAMP2 (show VAMP2 Proteins). Depletion of endogenous CENPF disrupts GLUT4 (show SLC2A4 Proteins) trafficking

Human Centromere Protein F (CENPF) interaction partners

  1. Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells.

  2. Mitosin and pHH3 immunostaining predict poorer survival in astrocytomas WHO grades II and III.

  3. Our data identify CENPF as a new centriolar disease gene implicated in severe human ciliopathy and microcephaly related phenotypes

  4. the increased expression of CENPF plays an important role in the progression of PCa (show FLVCR1 Proteins).

  5. N-terminal microtubule-binding domain of CENP-F prefers curled (show CCRN4L Proteins) oligomers of tubulin (show TUBB Proteins) relative to microtubule walls by approximately fivefold, suggesting it may contribute to the firm bonds between kinetochores and flared plus ends of dynamic microtubules

  6. FOXM1 (show FOXM1 Proteins) and CENPF function synergistically to promote tumor growth by coordinated regulation of target gene expression and activation of key signaling pathways associated with prostate cancer malignancy.

  7. CENP-F may serve as valuable molecular marker for predicting prognosis of ESCC patients. data indicate potential benefit of combining ZOL with cisplatin in ESCC; CENP-F expressionmay have therapeutic implications.

  8. data suggest that CENPF is frequently overexpressed in HCC (show FAM126A Proteins) and plays a critical role in driving HCC (show FAM126A Proteins) tumorigenesis

  9. Data suggest that ASUN promotes perinuclear enrichment of dynein at G2/M that facilitates BICD2- and CENP-F-mediated anchoring of dynein to nuclear pore complexes.

  10. Coincidently amplified CDK13 (show CDK13 Proteins), GMNN (show GMNN Proteins), and CENPF genes can play a role as common cancer-driver genes in human cancers.

CENPF Protein Profile

Protein Summary

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.

Gene names and symbols associated with Centromere Protein F Proteins (CENPF)

  • centromere protein F (LOC100222985)
  • centromere protein F (LOC100343995)
  • centromere protein F (Cenpf)
  • centromere protein F, (mitosin) (cenpf)
  • centromere protein F, 350/400kDa (CENPF)
  • centromere protein F, 350/400kDa (Cenpf)
  • centromere protein F, 350/400kDa (mitosin) (CENPF)
  • 6530404A22Rik protein
  • AI325968 protein
  • CENF protein
  • CMF1 protein
  • hcp-1 protein
  • im:7140452 protein
  • im:7144238 protein
  • im:7154719 protein
  • im:7156761 protein
  • Lek1 protein
  • LOC100222985 protein
  • mitosin protein
  • PRO1779 protein
  • si:ch211-152h14.2 protein

Protein level used designations for Centromere Protein F Proteins (CENPF)

centromere protein F , centromere autoantigen F , leucine, glutamic acid, lysine family 1 protein , LEK/centromere protein , AH antigen , CENP-F kinetochore protein , cell-cycle-dependent 350K nuclear protein , centromere protein F, 350/400kDa (mitosin) , centromere protein F, 350/400ka (mitosin) , kinetochore protein CENPF , mitosin , cardiac muscle factor 1 CMF1

100222985 Taeniopygia guttata
100343995 Oryctolagus cuniculus
108000 Mus musculus
257649 Rattus norvegicus
497403 Danio rerio
1063 Homo sapiens
100720167 Cavia porcellus
100521032 Sus scrofa
395357 Gallus gallus
101112149 Ovis aries
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