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Centromere Protein T Proteins (CENPT)

The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. Additionally we are shipping CENPT Kits (23) and CENPT Antibodies (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CENPT 80152 Q96BT3
CENPT 320394 Q3TJM4
CENPT 307805 Q561R1
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Top CENPT Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,474.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CENPT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Centromere Protein T (CENPT) Interaction Partners

Xenopus laevis Centromere Protein T (CENPT) interaction partners

  1. These results support the existence of 2 pathways for kinetochore assembly directed by CENP-C and CENP-T/W, which can be reconstituted in Xenopus egg extracts.

Human Centromere Protein T (CENPT) interaction partners

  1. We used a synthetic system to dissect how CenH3(CENP-A (show CENPA Proteins)) contributes to the accumulation of CENP-C and CENP-T, two key components that are necessary for the formation of functional kinetochores

  2. CENP-T directly interacts with Ndc80 (show NDC80 Proteins), which in turn promotes KNL1/Mis12 (show MIS12 Proteins) complex recruitment at kinetochores during chromosome segregation.

  3. CSN5 regulates the stability of the inner kinetochore components CENP-T and CENP-W, providing the first direct link between CSN5 and the mitotic apparatus, highlighting the role of CSN5 as a multifunctional cell cycle regulator.

  4. CENP-T provides a structural platform for outer kinetochore assembly.

  5. results reveal the molecular function of CENP-T proteins and demonstrate how the Ndc80 (show NDC80 Proteins) complex is anchored to centromeres in a manner that couples chromosome movement to spindle dynamics

  6. The CENP-T/W complex assembles through a dynamic exchange mechanism in late S-phase and G2, is required for mitosis in each cell cycle and does not persist across cell generations.

  7. Study demonstrates that CENP-W (show CENPW Proteins) forms a DNA-binding complex together with the CCAN component CENP-T; this complex directly associates with nucleosomal DNA and with canonical histone H3 (show HIST3H3 Proteins), but not with CENP-A (show CENPA Proteins), in centromeric regions.

  8. CENP-T exchange into centromeres is restricted to the S-phase of the cell cycle as revealed by FRAP (show FRAP1 Proteins), suggesting a coreplicational loading mechanism.

CENPT Protein Profile

Protein Summary

The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006

Gene names and symbols associated with Centromere Protein T Proteins (CENPT)

  • centromere protein T (cenpt)
  • centromere protein T (CENPT)
  • si:ch211-225g23.1 (si:ch211-225g23.1)
  • centromere protein T (Cenpt)
  • C16orf56 protein
  • CENP-T protein
  • G630055P03Rik protein
  • MGC145722 protein
  • RGD1309383 protein
  • wu:fc31h11 protein
  • wu:fc75c05 protein

Protein level used designations for Centromere Protein T Proteins (CENPT)

centromere protein T , centromere protein T-like , fc31h11 , fc75c05 , interphase centromere complex protein 22 , CENP-T

GENE ID SPECIES
779753 Xenopus (Silurana) tropicalis
100158304 Xenopus laevis
415654 Gallus gallus
454175 Pan troglodytes
562197 Danio rerio
100393620 Callithrix jacchus
80152 Homo sapiens
320394 Mus musculus
307805 Rattus norvegicus
611127 Canis lupus familiaris
513195 Bos taurus
101115894 Ovis aries
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