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The product of CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins.
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Human Polyclonal CEP350 Primary Antibody for IHC, ELISA - ABIN1534758
Makalowska, Sood, Faruque, Hu, Robbins, Eddings, Mestre, Baxevanis, Carpten: Identification of six novel genes by experimental validation of GeneMachine predicted genes. in Gene 2002
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CEP350 is a tumor-suppressor gene in human melanoma.
CAP350 interacts directly with FOP (FGFR1 oncogene partner (show FGFR1OP Antibodies)) to form a centrosomal complex required for microtubule anchoring.
CAP350 specifically stabilises Golgi-associated microtubules and in this way participates in the maintenance of a continuous pericentrosomal Golgi ribbon.
The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.
centrosome-associated protein 350
, centrosomal protein 350kDa
, centrosome-associated protein 350-like