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Ceramide Kinase Proteins (CERK)

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Additionally we are shipping CERK Antibodies (63) and CERK Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CERK 64781 Q8TCT0
CERK 223753 Q8K4Q7
Rat CERK CERK 300129  
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Top CERK Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Sf-9 Cells Human Un-conjugated   10 μg Log in to see 4 to 6 Days

CERK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for Ceramide Kinase (CERK) Interaction Partners

Human Ceramide Kinase (CERK) interaction partners

  1. our findings identify a functional role for Cerk in breast cancer recurrence and suggest the clinical utility of agents targeted against this prosurvival pathway.

  2. Data suggest that inhibition of ceramide kinase (CerK) [by specific gene silencing or pharmacological inhibition] drastically reduced cell proliferation in a neuroblastoma (show ARHGEF16 Proteins) cell line.

  3. TNF-alpha (show TNF Proteins) exposure of human SH-SY5Y neuroblastoma (show ARHGEF16 Proteins) caused a profound increase in CERK activity.

  4. Expression of hCERK enhanced ceramide-1-phosphate formation and release of arachidonic acid in Ca(2 (show CA2 Proteins)+) ionophore-stimulated cells.

  5. We have identified a differential role for ceramide kinase in mast-cell activation

  6. ceramide kinase and its product, C-1-P, have roles in arachidonic acid release and production of eicosanoids

  7. CERK translocates during activation from the cytosol to a lipid raft fraction

  8. Pleckstrin (show PLEK Proteins) homology domain of CERK is not only indispensable for its activity but also act as a regulator of CERK activity.

  9. sphingoid chain was also required for substrate recognition by CERK

  10. Recombinant CERK was analyzed with regard to dependence on divalent cations, to substrate delivery, specificity, and stereoselectivity. CERK associated with the plasma membrane in CHO cells, which is mediated by the N-terminal putative pleckstrin (show PLEK Proteins) domain.

Mouse (Murine) Ceramide Kinase (CERK) interaction partners

  1. there are significant differences in eicosanoid levels in ex vivo CERK(-/-) cells compared with wild-type counterparts, but the effect of the genetic ablation of CERK on eicosanoid synthesis and the serum levels of C1P was not apparent in vivo

  2. role of ceramide kinase in obesity and insulin (show INS Proteins) resistance

  3. Results indicate that C1P produced by CERK has a negative effect on the processing/secretion of TNFalpha (show TNF Proteins) via modulation of TACE (show ADAM17 Proteins) activity.

  4. role of CerK on the activation of mast cells

  5. The mechanism of ceramide-mediated inhibition is likely to involve conversion of ceramide to ceramide 1-phosphate by CERK.

  6. LPS (show TLR4 Proteins) inhibits the transcriptional activity of the Cerk proximal promoter;transcriptional repression of Cerk by LPS (show TLR4 Proteins) is not a primary consequence of LPS (show TLR4 Proteins)-induced cell cycle blockade.

  7. Findings suggest that CerK is not necessary for survival at an individual level, but might be involved in higher brain function related to emotion.

  8. CerK is essential to ceramide 1-phosphate formation via phosphorylation of Cer (show CBLN1 Proteins)

  9. Ceramide kinase is a key regulator of ceramide 1-phosphate, dihydroceramide and ceramide levels, with important implications for neutrophil homeostasis and innate immunity regulation.

CERK Protein Profile

Protein Summary

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006

Gene names and symbols associated with Ceramide Kinase Proteins (CERK)

  • ceramide kinase (CERK)
  • ceramide kinase (cerk)
  • zgc:158263 (zgc:158263)
  • ceramide kinase (CpipJ_CPIJ003342)
  • ceramide kinase (LOAG_11245)
  • Ceramide kinase (Cerk)
  • ceramide kinase (AaeL_AAEL015603)
  • Ceramide kinase (Bm1_50005)
  • ceramide kinase (Cerk)
  • AI848610 protein
  • CERK protein
  • CG16708 protein
  • D330016D08Rik protein
  • dA59H18.2 protein
  • dA59H18.3 protein
  • dcerk protein
  • Dmel\\CG16708 protein
  • hCERK protein
  • LK4 protein
  • MGC81777 protein
  • mKIAA1646 protein
  • si:ch211-162i19.1 protein

Protein level used designations for Ceramide Kinase Proteins (CERK)

ceramide kinase , CG16708-PA , CG16708-PB , Cerk-PA , Cerk-PB , Ceramide kinase , acylsphingosine kinase , lipid kinase 4 , lipid kinase LK4 , mCERK

100053604 Equus caballus
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458921 Pan troglodytes
425523 Gallus gallus
558496 Danio rerio
444466 Xenopus laevis
791197 Danio rerio
6034795 Culex quinquefasciatus
9948698 Loa loa
40640 Drosophila melanogaster
5579301 Aedes aegypti
6104885 Brugia malayi
64781 Homo sapiens
223753 Mus musculus
100336737 Bos taurus
300129 Rattus norvegicus
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