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Ceramide Kinase-Like Proteins (CERKL)

CERKL was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. Additionally we are shipping Ceramide Kinase-Like Antibodies (22) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CERKL 375298 Q49MI3
Mouse CERKL CERKL 228094  
Rat CERKL CERKL 502640  
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Top Ceramide Kinase-Like Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CERKL Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Ceramide Kinase-Like (CERKL) Interaction Partners

Human Ceramide Kinase-Like (CERKL) interaction partners

  1. The initial presenting features of CERKL-related retinopathy are distinct and unusual. Recognition of this initial presenting phenotype can facilitate earlier molecular diagnosis and genetic counseling.

  2. pVHL (show VHL Proteins) interacts with CERKL and ubiquitinates it for oxygen dependent proteasomal degradation.

  3. CERKL interacts with TRX2 (show TXN2 Proteins) and plays a novel key role in the regulation of the TRX2 (show TXN2 Proteins) antioxidant pathway.

  4. An unexpected multiplicity of CERKL transcriptional start sites (four in each species) plus a high variety of alternative splicing events primarily affecting the 5' half of the gene generate >20 fully validated mRNA isoforms in human and 23 in mouse.

  5. Novel mutation in CERKL which encompassed 13 exons is identified in retinitis pigmentosa

  6. Data suggest a functional link between CERKL, a new ceramide kinase (show CERK Proteins) homolog, and its nucleolar localization.

  7. Identification of a nuclear localization signal that might be responsible for nucleolar retention of CERKL.

  8. c.238+1G>A is the second reported mutation of CERKL and is a prevalent founder mutation that underlies approximately 33% of autosomal recessive retinal degeneration cases in the Yemenite Jewish population.

  9. This is the third reported mutation in CERKL causing retinal degeneration but is the first report to show that a single amino acid change in CERKL, rather than a null mutation, can cause retinal disease.

  10. Retinitis pigmentosa gene ceramide kinase-like (CERKL) was analyzed to determine CERKL function and contribution to pathogenesis.

Mouse (Murine) Ceramide Kinase-Like (CERKL) interaction partners

  1. In conclusion, the retina had the highest level of Cerkl mRNA and protein expression, which reached its maximum in the adult retina; and its expression decreased in NeuroD1 knock-out retina.

  2. Cerkl-/- knockdown shows a mild retinal phenotype, with increased levels of cellular stress and apoptosis indicators, and clear signs of functional alteration at the ganglion cell layer, but no detectable morphological changes.

  3. An unexpected multiplicity of CERKL transcriptional start sites (four in each species) plus a high variety of alternative splicing events primarily affecting the 5' half of the gene generate >20 fully validated mRNA isoforms in human and 23 in mouse.

  4. The purpose of this work was to investigate alternative splicing, and the temporal and spatial expression pattern of CERKL in the mouse retina.

  5. This work shows that CerkL does not contribute to phosphorylation of Cer and has no impact on Cer and C16-C1P levels in the retina.

Ceramide Kinase-Like (CERKL) Protein Profile

Protein Summary

This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.

Gene names and symbols associated with Ceramide Kinase-Like Proteins (CERKL)

  • ceramide kinase-like (CERKL)
  • ceramide kinase-like (LOC408315)
  • ceramide kinase-like (LOC617767)
  • ceramide kinase-like (LOC100551089)
  • ceramide kinase-like (LOC100566923)
  • ceramide kinase-like (LOC100604178)
  • ceramide kinase-like (LOC100645684)
  • ceramide kinase-like (Cerkl)
  • GB19002 protein
  • Gm1958 protein
  • RGD1561057 protein
  • Rp26 protein

Protein level used designations for Ceramide Kinase-Like Proteins (CERKL)

ceramide kinase-like , ceramide kinase-like protein-like , ceramide kinase-like protein , retinitis pigmentosa 26 (autosomal recessive)

GENE ID SPECIES
459793 Pan troglodytes
488430 Canis lupus familiaris
710256 Macaca mulatta
100027469 Monodelphis domestica
100346364 Oryctolagus cuniculus
100387975 Callithrix jacchus
408315 Apis mellifera
424120 Gallus gallus
617767 Bos taurus
100551089 Meleagris gallopavo
100566923 Anolis carolinensis
100604178 Nomascus leucogenys
100645684 Bombus terrestris
375298 Homo sapiens
228094 Mus musculus
502640 Rattus norvegicus
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