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CERS1 encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping Ceramide Synthase 1 Antibodies (40) and many more products for this protein.
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This study highlights a close interaction between CLN5 (show CLN5 Proteins)/CLN8 proteins, and their role in sphingolipid metabolism. Our findings suggest that CLN5p/CLN8p most likely are positive modulators of CerS1 and/or CerS2 (show CERS2 Proteins).
Moreover, an alternatively spliced variant CerS1 mRNA (CerS1-2) was detected mainly in cancer cells or primary tumour tissues compared to controls, which was targeted by miR (show MLXIP Proteins)-574-5p for degradation
The variation in LASS1 is functional, causing enhanced expression of the gene, and it contributes to healthy aging and greater survival in the tenth decade of life.
The study suggests that diverse stresses initiate responses through different signaling pathways, which ultimately converge to regulate CerS1 localization.
regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cel
LAG1 (show CCL4 Proteins) and C18 (show BBS9 Proteins)-ceramide have roles in the regulation of growth of HNSCC
The strong association of LCB (show CLTB Proteins) levels with neuronal survival both in vivo and in vitro suggests high-level accumulation of LCBs is a possible underlying cause of the CerS1 deficiency-induced neuronal death.
CerS1, -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (show SIRT3 Proteins)-null mice.
Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1-Cers6 (show CERS6 Proteins)) activity in macrophages is responsible for the accumulation of ceramide.
an essential function of CerS1-derived ceramide in the regulation of cerebellar development and neurodevelopmentally regulated behavior.
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1.
longevity assurance gene 1
, longevity assurance (LAG1, S. cerevisiae) homolog 1
, longevity assurance gene 1 protein homolog 1
, protein UOG-1
, upstream of GDF1
, LAG1 homolog, ceramide synthase 1
, LAG1 longevity assurance homolog 1
, longevity assurance homolog 1
, longevity assurance-like protein 1