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CERS2 encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Additionally we are shipping Ceramide Synthase 2 Antibodies (49) and Ceramide Synthase 2 Proteins (5) and many more products for this protein.
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Data show that 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9 (show AGPAT9 ELISA Kits)) inhibit cell growth by regulating expression of KLF4 (show KLF4 ELISA Kits)/LASS2/V-ATPase (show ATP6V1H ELISA Kits) proteins in breast cancer.
these results indicate that miR (show MLXIP ELISA Kits)-9 upregulation might be associated with malignant phenotype of bladder cancer. miR (show MLXIP ELISA Kits)-9 promotes chemoresistance of bladder cancer cells by target LASS2.
Data show that CERS2 expression was markedly different between various breast cancer cells and inversely correlated with cell invasion.
silencing of TMSG1 increased V-ATPase (show ATP6V1H ELISA Kits) activity, decreased extracellular pH and in turn the activation of secreted MMP-2 (show MMP2 ELISA Kits), which ultimately promoted metastasis capacity of breast cancer cell.
Results confirmed that TMSG1 is a potential metastasis suppressor gene, and suggested that the mechanism involved the induction of apoptosis and inhibition of cell proliferation via a caspase (show CASP3 ELISA Kits)-dependent mitochondrial pathway.
the vacuolar ATPase (V-ATPase (show DNAH8 ELISA Kits)) activity and extracellular hydrogen ion concentration were significantly decreased and the activity of secreted matrix metalloproteinase-2 (MMP-2 (show MMP2 ELISA Kits)) was downregulated in MCF-7 cells overexpressing LASS2/TMSG1
the inhibitory effect of the LASS2 on growth, invasion and metastasis of prostate cancer cells
Co-expression of CerS2 with CerS4/CerS6 reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation.
expression and role of ceramide synthase-2 in the lung
results contribute to the conclusion that LASS2/TMSG1 could regulate V-ATPase (show ATP6V1H ELISA Kits) activity and intracellular pH through the direct interaction of its homeodomain and the C subunit of V-ATPase (show ATP6V1H ELISA Kits)
CerS1 (show CERS1 ELISA Kits), -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (show SIRT3 ELISA Kits)-null mice.
Haploinsufficiency for this enzyme altered the pattern of ceramide acylation in the liver without affecting total ceramide levels, replacing very-long-chain ceramides with long-chain C16-ceramides.
Development of pheochromocytoma in ceramide synthase 2 null mice
our data strongly indicate that G-CSF (show CSF3 ELISA Kits)-induced CXCR2 (show CXCR2 ELISA Kits) expression is regulated in a CerS2-dependent manner and that CerS2 thereby promotes the migration of neutrophils, thus, contributing to inflammation and the development of EAE and MS.
Data indicate that the augmented rate of death of ceramide synthase 2 (CerS2) null mice is due to elevated levels of tumor necrosis factor alpha (TNFalpha (show TNF ELISA Kits)) secretion as a result of enhanced activity of TNFalpha (show TNF ELISA Kits)-converting enzyme (TACE (show ADAM17 ELISA Kits)).
CerS2-deficient kidneys were completely depleted of phytosphingosine-containing cortical sulfatides without any compensatio
we first report that Lass2 deficiency caused the downregulation of miR (show MLXIP ELISA Kits)-694 and the upregulation of its target gene Tnfaip3 (show TNFAIP3 ELISA Kits) in vivo in mice, which may be related to a high risk of occurrence of hepatocellular carcinoma
The identification of specific cell types in which CerS2 protein is expressed is prerequisite to further mechanistic characterization of phenotypic abnormalities exhibited by CerS2-deficient mice.
Lass2 is a protective gene against diethylnitrosamine-induced liver tumorigenesis; and upregulation of the TGF-beta1 (show TGFB1 ELISA Kits)-Smad4 (show SMAD4 ELISA Kits)-PAI-1 (show SERPINE1 ELISA Kits) axis may contribute to the vulnerability of Lass2-knockout mice to diethylnitrosamine.
Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1-Cers6) activity in macrophages is responsible for the accumulation of ceramide.
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.
LAG1 homolog, ceramide synthase 2
, LAG1 longevity assurance 2
, longevity assurance (LAG1, S. cerevisiae) homolog 2
, tumor metastasis-suppressor gene 1 protein
, LAG1 longevity assurance homolog 2
, TRAM homolog 3
, longevity assurance homolog 2
, translocating chain-associating membrane protein homolog 3