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May be involved in sphingolipid synthesis or its regulation (By similarity).. Additionally we are shipping Ceramide Synthase 6 Proteins (7) and and many more products for this protein.
Showing 10 out of 58 products:
Human Polyclonal CERS6 Primary Antibody for ELISA, WB - ABIN566978
Senkal, Ponnusamy, Rossi, Bialewski, Sinha, Jiang, Jazwinski, Hannun, Ogretmen: Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. in Molecular cancer therapeutics 2007
Show all 9 Pubmed References
Human Monoclonal CERS6 Primary Antibody for IHC (p), ELISA - ABIN566979
: in 1970
Show all 7 Pubmed References
This study has shown that by direct transcriptional activation of CerS6, p53 (show TP53 Antibodies) can regulate specific ceramide biosynthesis, which contributes to the pro-apoptotic cellular response.
silencing of CerS6 induced the increased expression of GLUT1 (show SLC2A1 Antibodies), which downregulated the expression of WNT5A (show WNT5A Antibodies) and enhanced the invasion and proliferation of melanoma cells.
Identification of CerS6 and ceramide pathways as a novel Methotrexate target.
stichoposide D inhibits growth of experimental leukemia by activating Fas (show FAS Antibodies)/ceramide synthase 6/p38 (show CRK Antibodies) kinase in lipid rafts
CERS6-dependent ceramide synthesis and maintenance of ceramide in the cellular membrane are essential for lamellipodia formation and metastasis.
Data indicate that ceramide synthase 6 (CerS6) expression is upregulated in leukocytes from multiple sclerosis (MS) patients.
On the basis of its pivotal role in regulating cell death upon COX (show COX8A Antibodies) dysfunction, CerS6 might potentially represent a novel target for therapeutic intervention in mitochondrial diseases caused by COX (show COX8A Antibodies) dysfunction.
Taken together, these results suggest that increased expression of CerS6 can mediate transcriptional activation of acid ceramidase (show ASAH1 Antibodies) in a JNK (show MAPK8 Antibodies)-dependent manner that is independent of CerS6 activity.
CerS6 as a novel epithelial-mesenchymal transition-regulated gene that has a pivotal role in the regulation of cell migration.
Upregulation of CERS6 in an experimental autoimmune encephalomyelitis model is sex dependent.
CerS1 (show CERS1 Antibodies), -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (show SIRT3 Antibodies)-null mice.
CerS6 deletion increases energy expenditure and improves glucose tolerance, not only in CerS6(Delta/Delta) mice, but also in brown adipose tissue- (CerS6(DeltaBAT)) and liver-specific (CerS6(DeltaLIVER)) CerS6 knockout mice.
Data show that ceramide synthase 6 knockout (CerS6KO) experimental autoimmune encephalomyelitis (EAE) mice exhibit exacerbated progression of clinical symptoms.
Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1 (show CERS1 Antibodies)-Cers6) activity in macrophages is responsible for the accumulation of ceramide.
CerS6 protein is N-glycosylated and expressed in several tissues of mice, mainly kidney, small and large intestine, and brain.
An important role is revealed for C16:0-Cer (show CBLN1 Antibodies) (ceramide synthase 6) in the inflammatory process and subsequently in the induction of experimental autoimmune encephalitis.
Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6 (show ATF6 Antibodies)-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2 (show CA2 Antibodies)+ and ER/Golgi membrane network
May be involved in sphingolipid synthesis or its regulation (By similarity).
LAG1 homolog, ceramide synthase 6
, longevity assurance homolog 6
, LAG1 longevity assurance homolog 6