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Cereblon Proteins (CRBN)

CRBN encodes a protein related to the Lon protease protein family. Additionally we are shipping Cereblon Antibodies (34) and Cereblon Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CRBN 297498 Q56AP7
CRBN 51185 Q96SW2
CRBN 58799 Q8C7D2
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Top Cereblon Proteins at

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

CRBN Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human ,
Mouse (Murine)

Top referenced Cereblon Proteins

  1. Human CRBN Protein expressed in Wheat germ - ABIN1350279 : Charoenfuprasert, Yang, Lee, Chao, Chu, Lai, Hsu, Chang, Chen, Chen, Chang, Leu, Shih: Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer. in Oncogene 2011 (PubMed)

More Proteins for Cereblon (CRBN) Interaction Partners

Human Cereblon (CRBN) interaction partners

  1. IRF4 (show IRF4 Proteins) and CRBN polymorphisms affect risk and response to treatment in multiple myeloma

  2. overview of the current understanding of mechanism of action of Immunomodulatory drugs via CRBN and prospects for the development of new drugs that degrade protein of interest.

  3. 45.2 of multiple myeloma patients were CRBN(+). Among patients treated with thalidomide-based regimens, CRBN(+) patients showed a better treatment response than did CRBN-negative patients. There was no significant difference in survival outcomes between thalidomide- and bortezomib-based regimens in CRBN(+) patients.

  4. These results support the notion that the cereblon binding partner AGO2 (show EIF2C2 Proteins) plays an important role in regulating MM cell growth and survival and AGO2 (show EIF2C2 Proteins) could be considered as a novel drug target for overcoming IMiD resistance in MM cells.

  5. The anti-PEL effects of IMiDs involved cereblon-dependent suppression of IRF4 (show IRF4 Proteins) and rapid degradation of IKZF1 (show IKZF1 Proteins), but not IKZF3 (show IKZF3 Proteins). Small hairpin RNA-mediated knockdown of MYC (show MYC Proteins) enhanced the cytotoxicity of IMiDs

  6. GS is acetylated at lysines 11 and 14, yielding a degron that is necessary and sufficient for binding and ubiquitylation by CRL4(CRBN) and degradation by the proteasome.

  7. Structural dynamics of the cereblon ligand binding domain.

  8. Our data are consistent with the idea that the CUL4A (show CUL4A Proteins)/B-DDB1 (show DDB1 Proteins)-CRBN complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 (show CLCN1 Proteins) channels.

  9. Data suggest that cereblon (CRBN) expression in peripheral blood chronic lymphocytic leukemia (CLL) cells is independent of prognostic factors and may be considered a potential biomarker.

  10. High levels of full-length CRBN mRNA in lower risk 5q deletion patients are necessary for the efficacy of lenalidomide.

Mouse (Murine) Cereblon (CRBN) interaction partners

  1. CRBN is involved in the activation of PERK (show EIF2AK3 Proteins) and the Ire1 (show ERN1 Proteins) pathway of the unfolded protein response.CRBN plays a role in cellular stress signaling, including the unfolded protein response, by controlling the activity of AMPK (show PRKAA1 Proteins).

  2. results of this study suggest a plausible mechanism for CRBN involvement in higher brain function in humans, and they may help explain how a specific mutation in CRBN can affect the cognitive ability of patients

  3. Found significantly smaller infarct sizes and less fibrosis in the hearts of CRBN KO mice than in those of WT mice. Apoptosis was also significantly reduced in the KO mice compared with that in WT mice.

  4. findings suggest that crbn-/- mice exhibit selective HPC-dependent deficits in associative learning.

  5. CRBN directly interacts with the alpha1 subunit of AMP-activated protein kinase (AMPK (show PRKAA2 Proteins) alpha1) and inhibits the activation of AMPK (show PRKAA1 Proteins) activation.

  6. These results imply that Nrf2 (show NFE2L2 Proteins) stimulates CRBN gene transcription under hypoxia-reoxygenation conditions in neuronal cells.

Cereblon (CRBN) Protein Profile

Protein Summary

This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Cereblon Proteins (CRBN)

  • cereblon (crbn)
  • cereblon (CRBN)
  • ATP-dependent protease La (LON) domain protein (AT2G25740)
  • cereblon (Crbn)
  • 2610203G15Rik protein
  • 2900045O07Rik protein
  • AF229032 protein
  • AW108261 protein
  • F3N11.21 protein
  • MRT2 protein
  • MRT2A protein
  • piL protein
  • zgc:92404 protein

Protein level used designations for Cereblon Proteins (CRBN)

protein cereblon , zcrbn , cereblon , protein cereblon-like , protein x 0001 , novel lethal , protein PiL , Protein cereblon

445491 Danio rerio
100052958 Equus caballus
704436 Macaca mulatta
460130 Pan troglodytes
493554 Xenopus (Silurana) tropicalis
100022278 Monodelphis domestica
100479474 Ailuropoda melanoleuca
817117 Arabidopsis thaliana
100584605 Nomascus leucogenys
297498 Rattus norvegicus
51185 Homo sapiens
58799 Mus musculus
511585 Bos taurus
416104 Gallus gallus
476551 Canis lupus familiaris
100174633 Pongo abelii
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