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Ceroid-Lipofuscinosis, Neuronal 3 Proteins (CLN3)

CLN3 encodes a protein that is involved in lysosomal function. Additionally we are shipping CLN3 Antibodies (34) and CLN3 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLN3 12752 Q61124
CLN3 1201 Q13286
Rat CLN3 CLN3 293485  
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Top CLN3 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days

CLN3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,

More Proteins for Ceroid-Lipofuscinosis, Neuronal 3 (CLN3) Interaction Partners

Mouse (Murine) Ceroid-Lipofuscinosis, Neuronal 3 (CLN3) interaction partners

  1. findings in two distinct lysosome-related degradative pathways constitute the first description of a deficit in the retinal pigment epithelium caused by loss of CLN3

  2. The small GTPase (show RACGAP1 Proteins) Cdc42 (show CDC42 Proteins) is misregulated in the absence of CLN3, and thus may be a common link to multiple cellular defects.

  3. Rssults suggested that CLN2 (show TPP1 Proteins), CLN3 and CLN5 (show CLN5 Proteins) genes may play an important role in early embryonal neurogenesis.

  4. The aim of our study was to investigate the visual disease progression in the Cln3 (Deltaex7/8) mice.

  5. CLN3 facilitates transport of microdomain-associated proteins.

  6. results demonstrate altered glutamate (show GRIN1 Proteins) receptor function in Cln3(Deltaex7/8) neurons and suggest that both AMPA (show GRIA3 Proteins) and NMDA receptors are potential therapeutic targets in juvenile neuronal ceroid lipofuscinosis (show CLN6 Proteins)

  7. The migration defect in Cln3(-/-) results, in part, from the loss of the CLN3-myosin-IIB interaction.

  8. Findings suggest an osmoregulated role for CLN3p in renal medullary control of water and K(+) balance.

  9. Cln3(Deltaex7/8) knock-in mice with the common juvenile-onset neuronal ceroid lipofuscinosis (show CLN6 Proteins) (JNCL; Batten disease) mutation exhibit progressive neurologic disease that begins before birth.

  10. we investigated endogenous Cln3p expression using two peptide antibodies raised against two distinct epitopes of murine Cln3p.

Human Ceroid-Lipofuscinosis, Neuronal 3 (CLN3) interaction partners

  1. CLN3 knockdown inhibits cell proliferation and induces G0/G1 cell cycle arrest in the A2780 cell line and its drug-resistant sub-lines.

  2. The membrane topology of human CLN3 protein.

  3. The eyes and vision of heterozygous carriers of CLN3 disease showed normal features when compared to a control group, which controverts a previously suggested retinal dysfunction in these subjects.

  4. This new model system, which allows for the study of Cln3 function in both single cells and a multicellular organism, together with the observation that expression of human CLN3 restores abnormalities in Dictyostelium cln3- cells

  5. These results further support an important role for the CLN3 protein in intracellular Ca(2 (show CA2 Proteins)+) handling and in autophagic pathway flux and establish a powerful new platform for therapeutic screening.

  6. CLN3 mutation is associated with neuronal ceroid lipofuscinosis (show CLN6 Proteins).

  7. Genetic testing for CLN3 should be considered in autophagic vacuolar myopathy (AVM), with autophagic vacuoles and sarcolemmal features.

  8. CLN3 was identified as a novel disease gene for non-syndromic retinal diseases as supported by five unrelated patient families in this study.

  9. CLN3 is involved in the response and adaptation to cellular stress.

  10. Protein interaction mapping analysis suggests CLN3 is involved in transmembrane transport, lipid homeostasis, neuronal excitability and link it to G-protein signaling and protein folding/sorting in the endoplasmic reticulum.

Cow (Bovine) Ceroid-Lipofuscinosis, Neuronal 3 (CLN3) interaction partners

  1. The candidate genes for bovine Neuronal Ceroid Lipofuscinosis (show CLN6 Proteins), CLN3, CLN5 (show CLN5 Proteins) and CLN6 (show CLN6 Proteins), have been mapped to facilitate linkage analysis in cattle and sheep.

CLN3 Protein Profile

Protein Summary

This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with CLN3

  • ceroid-lipofuscinosis, neuronal 3 (cln3)
  • battenin (PTRG_05620)
  • ceroid-lipofuscinosis, neuronal 3 (CLN3)
  • ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) (Cln3)
  • ceroid-lipofuscinosis, neuronal 3 (Cln3)
  • AI323623 protein
  • BTS protein
  • GB12798 protein
  • JNCL protein
  • MGC80041 protein
  • zgc:92244 protein

Protein level used designations for CLN3

battenin , ceroid-lipofuscinosis, neuronal 3 , ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) , ceroid-lipofuscinosis, neuronal 3, juvenile , battenin-like , batten disease protein , Cln3p , ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)

492340 Danio rerio
6343873 Pyrenophora tritici-repentis Pt-1C-BFP
410860 Apis mellifera
446498 Xenopus laevis
467935 Pan troglodytes
739020 Pan troglodytes
100009244 Oryctolagus cuniculus
100124328 Xenopus (Silurana) tropicalis
100127354 Sus scrofa
100388249 Callithrix jacchus
100457403 Pongo abelii
100583151 Nomascus leucogenys
12752 Mus musculus
1201 Homo sapiens
479794 Canis lupus familiaris
504799 Bos taurus
293485 Rattus norvegicus
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