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Ceroid-Lipofuscinosis, Neuronal 6, Late Infantile, Variant (CLN6) ELISA Kits

CLN6 is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Additionally we are shipping Ceroid-Lipofuscinosis, Neuronal 6, Late Infantile, Variant Antibodies (30) and Ceroid-Lipofuscinosis, Neuronal 6, Late Infantile, Variant Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse CLN6 CLN6 76524  
Anti-Human CLN6 CLN6 54982 Q9NWW5
Anti-Rat CLN6 CLN6 315746  
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More ELISA Kits for Ceroid-Lipofuscinosis, Neuronal 6, Late Infantile, Variant Interaction Partners

Mouse (Murine) Ceroid-Lipofuscinosis, Neuronal 6, Late Infantile, Variant (CLN6) interaction partners

  1. Data indicate that ceroid-lipofuscinosis, neuronal 6 protein Cln6(nclf) mutation leads to deficits in motor coordination, vision, memory, and learning.

  2. These findings implicate Cln6 in the survival and maturation of specific neuronal populations during development and make it possible to compare regional Cln6 expression with the distribution of subsequent pathology.

  3. Data show a progressive breakdown of axons and synapses in the brains of two different models of NCL (show NCL ELISA Kits): Ppt1 (show PPT1 ELISA Kits)(-/-) model of infantile NCL (show NCL ELISA Kits) and Cln6(nclf) model of variant late-infantile NCL (show NCL ELISA Kits).

  4. We concluded that alterations in neurite maturation resulting from a loss of CLN6-CRMP-2 (show DPYSL2 ELISA Kits) interaction may contribute to neuronal dysfunction and pathology in vLINCL.

Human Ceroid-Lipofuscinosis, Neuronal 6, Late Infantile, Variant (CLN6) interaction partners

  1. describe the spectrum of clinical and neurophysiologic features associated with mutations of CLN6.

  2. study demonstrates the central role of the metal transporter, Zip7 (show SLC39A7 ELISA Kits), in the aberrant biometal metabolism of CLN6 variants of Neuronal ceroid lipofuscinoses.

  3. The study describes the first report in the North of Morocco of the CLN6 p.I154del mutation in 3 patients belonging to a large consanguineous family.

  4. our results add CLN6 to the genetic mutations causing teenage-onset progressive myoclonus epilepsy

  5. CLN6 and CLN3 mutations trigger distinct processes that converge on a shared pathway, which is responsible for proper subunit c protein turnover and neuronal cell survival.

  6. Sequencing of CLN6 will provide a simple diagnostic strategy in this disorder, in which definitive identification usually requires invasive biopsy.

  7. Expression studies of three mutations found in CLN6 patients predicted to affect transmembrane domain 3, cytoplasmic loop 2 or result in a truncated membrane protein respectively, is reported.

  8. gene mutated in variant late-infantile neuronal ceroid lipofuscinosis (CLN6) and in nclf mutant mice encodes a novel predicted transmembrane protein

  9. novel approximately 36-kD CLN6-gene product augments an intriguing set of unrelated membrane-spanning proteins, whose deficiency causes neuronal ceroid lipofuscinosis in mouse and man

  10. Eight novel mutations identified in CLN6 in 26 families with late infantile neuronal ceroid lipofuscinosis.

Cow (Bovine) Ceroid-Lipofuscinosis, Neuronal 6, Late Infantile, Variant (CLN6) interaction partners

  1. The candidate genes for bovine Neuronal Ceroid Lipofuscinosis, CLN3 (show CLN3 ELISA Kits), CLN5 (show CLN5 ELISA Kits) and CLN6, have been mapped to facilitate linkage analysis in cattle and sheep.

Ceroid-Lipofuscinosis, Neuronal 6, Late Infantile, Variant (CLN6) Antigen Profile

Antigen Summary

This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.

Gene names and symbols associated with CLN6

  • ceroid-lipofuscinosis, neuronal 6 (Cln6) antibody
  • ceroid-lipofuscinosis, neuronal 6, late infantile, variant (CLN6) antibody
  • ceroid-lipofuscinosis, neuronal 6, late infantile, variant (cln6) antibody
  • ceroid-lipofuscinosis, neuronal 6, late infantile, variant (Cln6) antibody
  • ceroid-lipofuscinosis, neuronal 6a (cln6a) antibody
  • 1810065L06Rik antibody
  • AW743417 antibody
  • CLN4A antibody
  • cln6 antibody
  • D9Bwg1455e antibody
  • HsT18960 antibody
  • nclf antibody
  • zgc:103565 antibody

Protein level used designations for CLN6

neuronal ceroid lipofuscinosis , ceroid-lipofuscinosis neuronal protein 6 , ceroid-lipofuscinosis neuronal protein 6 homolog

GENE ID SPECIES
76524 Mus musculus
54982 Homo sapiens
100127342 Xenopus laevis
415558 Gallus gallus
497068 Canis lupus familiaris
617615 Bos taurus
315746 Rattus norvegicus
100156072 Sus scrofa
449809 Danio rerio
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