You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Ceroid-Lipofuscinosis, Neuronal 8 (Epilepsy, Progressive with Mental Retardation) (CLN8) Antibodies

CLN8 encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLN8 26889 Q9QUK3
CLN8 2055 Q9UBY8
CLN8 306619 Q6AYM9
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-Ceroid-Lipofuscinosis, Neuronal 8 (Epilepsy, Progressive with Mental Retardation) Antibodies at antibodies-online.com

Showing 10 out of 43 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-CLN8 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CLN8 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: 293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB CLN8 Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CLN8 antibody detected the CLN8 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Dog Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit PE ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB CLN8 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
$532.71
Details

CLN8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


, , , , , , , , , , ,
Human , ,


, , , , , , , , , , , , , ,
Rat (Rattus) ,


, , , , , , , , , , ,

Top referenced anti-Ceroid-Lipofuscinosis, Neuronal 8 (Epilepsy, Progressive with Mental Retardation) Antibodies

  1. Dog (Canine) Polyclonal CLN8 Primary Antibody for WB - ABIN2776788 : Hermansson, Käkelä, Berghäll, Lehesjoki, Somerharju, Lahtinen: Mass spectrometric analysis reveals changes in phospholipid, neutral sphingolipid and sulfatide molecular species in progressive epilepsy with mental retardation, EPMR, brain: a case study. in Journal of neurochemistry 2005 (PubMed)

More Antibodies against Ceroid-Lipofuscinosis, Neuronal 8 (Epilepsy, Progressive with Mental Retardation) Interaction Partners

Mouse (Murine) Ceroid-Lipofuscinosis, Neuronal 8 (Epilepsy, Progressive with Mental Retardation) (CLN8) interaction partners

  1. This study demonistrated that Selective spatiotemporal patterns of glial activation and neuron loss in the sensory thalamocortical pathways in neuronal ceroid lipofuscinosis (show CLN6 Antibodies) 8 decifiency mice.

  2. The amount of myelin was reduced in 1-month-old Cln8(mnd) mice, but reached normal levels by 5 months of age. The level of Cln8 gene expression followed the developmental pattern of myelin formation and was high in primary oligodendrocytes.

  3. This study demonistrated that the changes in glutamate (show GRIN1 Antibodies) receptor expression in the hippocampus of the mnd mouse.

  4. Mutations in mouse CLN8 gene show marked deficiency of mitochondrial Ca2 (show CA2 Antibodies)+ clearance in Cln8mnd neurons, and the heightened vulnerability of these neurons to excitotoxic effects of glutamate (show GRIN1 Antibodies).

  5. The mnd mouse mutation in CLN8 leads to progressive behavioral abnormalities prior to the onset of gross motor symptoms, linking the mutation via pathology to a quantifiable behavioral phenotype.

  6. A marked increase in astroglial and microglial cells, and in TNF (show TNF Antibodies) receptor TNFR-I (show TNFRSF1A Antibodies) immunoreactivity was observed in the spinal cord of motor neuron degeneration mutation (mnd) mice at the age of 4 month.

  7. Mutations in the CLN8 gene underlie Northern epilepsy and a subset of Turkish variant late infantile NCL (show NCL Antibodies). Inducing disease mutations in a mouse hippocampal neuronal cell line did not affect localization of CLN8.

  8. Expression of Cln8 in the developing and mature brain suggests roles for Cln8 in maturation, differentiation and supporting the survival of different neuronal populations.

Human Ceroid-Lipofuscinosis, Neuronal 8 (Epilepsy, Progressive with Mental Retardation) (CLN8) interaction partners

  1. This study does not support a contribution of rare missense CLN8 variations to ASD (show ARSD Antibodies) susceptibility in the Japanese population.

  2. This study highlights a close interaction between CLN5 (show CLN5 Antibodies)/CLN8 proteins, and their role in sphingolipid metabolism. Our findings suggest that CLN5p/CLN8p most likely are positive modulators of CerS1 (show CERS1 Antibodies) and/or CerS2 (show CERS2 Antibodies).

  3. A missense mutation at the CLN8 gene (763C>G)has been identified in 3 consanguineous Israeli-Arab patients. The phenotype in 2 of them is milder than that of their cousin who has typical neuronal ceroid lipofuscinosis (show CLN6 Antibodies).

  4. CLN8 is a candidate modifier gene for GD1. Increased expression may protect against severe GD1.It may function as a protective sphingolipid sensor and/or in glycosphingolipid trafficking.

  5. a novel, large CLN8 gene deletion c.544-2566_590del2613 in a Turkish family with a slightly more severe phenotype of neuronal ceroid lipofuscinose was described.

  6. patients with CLN8 mutations from Italy. In these patients, the onset of epilepsy occurred between 3 and 6 years of age, with myoclonic, tonic-clonic, and atypical absence seizures. Electroencephalograms revealed focal and/or generalized abnormalities.

  7. CLN8 plays a role in cell proliferation during neuronal differentiation and in protection against cell death.

Ceroid-Lipofuscinosis, Neuronal 8 (Epilepsy, Progressive with Mental Retardation) (CLN8) Antigen Profile

Protein Summary

This gene encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reticulum (ER), and may recycle between the ER and ER-Golgi intermediate compartment. Mutations in this gene are associated with progressive epilepsy with mental retardation (EMPR), which is a subtype of neuronal ceroid lipofuscinoses (NCL). Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain.

Gene names and symbols associated with CLN8

  • ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) (CLN8) antibody
  • ceroid-lipofuscinosis, neuronal 8 (Cln8) antibody
  • ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) (Cln8) antibody
  • C8orf61 antibody
  • EPMR antibody
  • mnd antibody

Protein level used designations for CLN8

ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) , protein CLN8 , motor neuron degeneration

GENE ID SPECIES
463962 Pan troglodytes
716441 Macaca mulatta
26889 Mus musculus
2055 Homo sapiens
488558 Canis lupus familiaris
530874 Bos taurus
306619 Rattus norvegicus
100624678 Sus scrofa
Selected quality suppliers for anti-Ceroid-Lipofuscinosis, Neuronal 8 (Epilepsy, Progressive with Mental Retardation) (CLN8) Antibodies
Did you look for something else?