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Charged Multivesicular Body Protein 2B (CHMP2B) ELISA Kits

CHMP2B encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. Additionally we are shipping CHMP2B Antibodies (67) and CHMP2B Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human CHMP2B CHMP2B 25978 Q9UQN3
Anti-Mouse CHMP2B CHMP2B 68942 Q8BJF9
Anti-Rat CHMP2B CHMP2B 363720  
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More ELISA Kits for CHMP2B Interaction Partners

Human Charged Multivesicular Body Protein 2B (CHMP2B) interaction partners

  1. Endogenous TMEM106B was partly sequestered in CHMP2B-positive structures. SNP T185 was more associated with CHMP2B than SNP S185, and it enhanced neurotoxicity caused by CHMP2B(Intron5) compared to S185-expressing cells.

  2. Study showed that mutant CHMP2B causes the pathological accumulation of endolysosomal components early in the frontotemporal dementia disease course

  3. Protein kinase CK2 (show CSNK2A1 ELISA Kits) alpha (show CSNK2A2 ELISA Kits) is involved in the phosphorylation of the ESCRT-III subunits CHMP3 (show CHMP3 ELISA Kits) and CHMP2B, as well as of VPS4B/SKD1 (show vps4b ELISA Kits), an ATPase (show DNAH8 ELISA Kits) that mediates ESCRT-III disassembly.

  4. Data indicate that knockdown of syntaxin 13 (syx13) further increased the cellular toxicity caused by muaant CHMP2B (CHMP2BIntron5) expression.

  5. CHMP2B immunoreactivity was increased in the dorsal motor nucleus of the vagus nerve in Parkinson's disease and incidental Lewy body disease brains

  6. These findings suggest that endosomal and autophagic pathway is associated with degradation or formation of alpha-synuclein (show SNCA ELISA Kits) aggregates in alpha-synucleinopathy.

  7. Subjects with CHMP2B mutation show cognitive changes dominated by executive dysfunctions, years before they fulfil diagnostic criteria of FTD (show FTL ELISA Kits).

  8. Direct link between disease-causing mutations and the cellular phenotype in cells originating from CHMP2B mutation patients with frontotemporal dementia.

  9. This study provided a better understanding of the cellular pathogenesis of neurodegenerative diseases associated with various missense mutations of CHMP2B as well as endocytic defects.

  10. CHMP2B polymerization scaffolds membranes in vivo represents a first step toward demonstrating its structural role during outward membrane deformation

Mouse (Murine) Charged Multivesicular Body Protein 2B (CHMP2B) interaction partners

  1. Study showed that mutant CHMP2B causes the pathological accumulation of endolysosomal components early in the frontotemporal dementia disease course

  2. This study showing that CHMP2B resides at synapses and is involved in synaptic plasticity.

  3. Forebrain-specific expression of frontotemporal dementia-associated mutant CHMP2B in mice causes several age-dependent neurodegenerative phenotypes, including social behavioral impairments.

  4. Chmp2b is one of the most highly regulated cell-autonomous targets of Lbx1 (show Lbx1 ELISA Kits) in the embryonic mouse neural tube

  5. These data describe the first mouse model of dementia caused by CHMP2B mutation and provide new insights into the mechanisms of CHMP2B-induced neurodegeneration

CHMP2B Antigen Profile

Antigen Summary

This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.

Gene names and symbols associated with CHMP2B

  • charged multivesicular body protein 2B (CHMP2B) antibody
  • chromatin modifying protein 2Ba (chmp2ba) antibody
  • chromatin modifying protein 2B (CHMP2B) antibody
  • charged multivesicular body protein 2B (Chmp2b) antibody
  • chromatin modifying protein 2Bb (chmp2bb) antibody
  • 1190006E07Rik antibody
  • ALS17 antibody
  • CHMP2.5 antibody
  • chmp2b antibody
  • chmp2bl antibody
  • DMT1 antibody
  • RGD1306781 antibody
  • si:ch211-224m9.5 antibody
  • VPS2-2 antibody
  • VPS2B antibody
  • zgc:77025 antibody

Protein level used designations for CHMP2B

chromatin modifying protein 2B , charged multivesicular body protein 2b , chmp2b , chromatin-modifying protein 2b , VPS2 homolog B , vacuolar protein-sorting-associated protein 2-2 , chromatin modifying protein 2B, like

GENE ID SPECIES
487675 Canis lupus familiaris
569532 Danio rerio
747711 Pan troglodytes
100172566 Pongo abelii
100224229 Taeniopygia guttata
25978 Homo sapiens
68942 Mus musculus
363720 Rattus norvegicus
615954 Bos taurus
418461 Gallus gallus
100516044 Sus scrofa
405840 Danio rerio
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