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Checkpoint with Forkhead and Ring Finger Domains Proteins

(Checkpoint with Forkhead and Ring Finger Domains (CHFR))
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).
CHFR Protein (AA 1-652) (GST tag) CHFR Protein (AA 1-652) (GST tag) CHFR Protein (AA 1-652) (GST tag) (ABIN1349312)

CHFR Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

CHFR Protein (AA 136-194) (GST tag) CHFR Protein (AA 136-194) (GST tag) CHFR Protein (AA 136-194) (GST tag) (ABIN1349314)

CHFR Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

CHFR Protein (AA 1-664) (Strep Tag) CHFR Protein (AA 1-664) (Strep Tag) CHFR Protein (AA 1-664) (Strep Tag) (ABIN3091433)

Crystallography grade CHFR Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS

Checkpoint with Forkhead and Ring Finger Domains Proteins by Grade

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Checkpoint with Forkhead and Ring Finger Domains Proteins by Origin

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Checkpoint with Forkhead and Ring Finger Domains Proteins by Source

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Checkpoint with Forkhead and Ring Finger Domains Proteins by Application

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Popular Checkpoint with Forkhead and Ring Finger Domains Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1349312
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1349314
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3091433
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3136097
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2713969
Quantity 20 μg
Datasheet Datasheet

Aliases for Checkpoint with Forkhead and Ring Finger Domains Proteins

checkpoint with forkhead and ring finger domains (CHFR) Proteins
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (chfr) Proteins
checkpoint with forkhead and ring finger domains (Chfr) Proteins
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog (chfr.L) Proteins
5730484M20Rik Proteins
C230082M18 Proteins
CHFR Proteins
fc43f10 Proteins
RNF116 Proteins
rnf116 Proteins
RNF196 Proteins
rnf196 Proteins
si:dkey-69h6.7 Proteins
wu:fc43f10 Proteins
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