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Chemokine (C-C Motif) Ligand 13 Proteins (CCL13)

CCL13 is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Additionally we are shipping Chemokine (C-C Motif) Ligand 13 Antibodies (104) and Chemokine (C-C Motif) Ligand 13 Kits (45) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCL13 6357 Q99616
Mouse CCL13 CCL13 17227 P21812
CCL13    
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Top Chemokine (C-C Motif) Ligand 13 Proteins at antibodies-online.com

Showing 10 out of 35 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$135.88
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 4 to 6 Days
$412.50
Details
HOST_Yeast (Pichia pastoris) Human His tag 100 μg Log in to see 11 to 13 Days
$862.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   1 mg Log in to see 2 to 3 Days
$4,173.75
Details
Yeast Human His tag 10 μg Log in to see 16 Days
$118.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 7 to 9 Days
$328.21
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 7 to 8 Days
$185.71
Details

CCL13 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
General

Top referenced Chemokine (C-C Motif) Ligand 13 Proteins

  1. Human CCL13 Protein expressed in Escherichia coli (E. coli) - ABIN2666779 : Uguccioni, Loetscher, Forssmann, Dewald, Li, Lima, Li, Kreider, Garotta, Thelen, Baggiolini: Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. in The Journal of experimental medicine 1996 (PubMed)
    Show all 8 references for ABIN2666779

  2. Human CCL13 Protein expressed in Escherichia coli (E. coli) - ABIN666792 : Garcia-Zepeda, Combadiere, Rothenberg, Sarafi, Lavigne, Hamid, Murphy, Luster et al.: Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through ... in Journal of immunology (Baltimore, Md. : 1950) 1997 (PubMed)

More Proteins for Chemokine (C-C Motif) Ligand 13 (CCL13) Interaction Partners

Human Chemokine (C-C Motif) Ligand 13 (CCL13) interaction partners

  1. CCL13 levels in serum and synovial fluid may serve as a biomarker for the progression of osteoarthritis.

  2. identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3 (show CCL3 Proteins), CCL4/CCL4L1 (show CCL4 Proteins)/CCL4L2, CD160 (show CD160 Proteins), IFNG (show IFNG Proteins), NR4A3 (show NR4A3 Proteins) and XCL1 (show XCL1 Proteins)/XCL2 (show XCL2 Proteins)) were analyzed in 127 kidney biopsies

  3. CCL13 is an antimicrobial protein with bacteriocidal activity against E. coli.

  4. Data suggest that CCL13 binds to several chemokine (show CCL1 Proteins) receptors (CCR1, CCR2 (show CCR2 Proteins), and CCR3 (show CCR3 Proteins)), allowing CCL13 to elicit different effects on target cells of immune system. CCL13 is involved in pathology of chronic inflammatory/autoimmune diseases. [REVIEW]

  5. MCP-4 and hsCRP may be the markers linking chronic inflammation in obesity and periodontal disease.

  6. E(2) has adverse effects on the pathogenesis of RA as a result of unregulated cell death, increased TNF-alpha (show TNF Proteins)-induced MMP-3 (show MMP3 Proteins) production, and CCL13 overproduction, subsequently resulting in the disease progression of RA.

  7. Data show that, for the small macrophages in COPD (show ARCN1 Proteins), increased transcript and protein levels for CCL2 (show CCL2 Proteins), CCL7 (show CCL7 Proteins), CCL13 and CCL22 (show CCL22 Proteins) with a more than 100-fold increase for CCL13 mRNA.

  8. Findings suggest that the pro-atherogenic effects of CCR2 (show CCR2 Proteins) may not be restricted to interaction with MCP-1 (show CCL2 Proteins), but could also involve activation by MCP-4, being an inflammatory link between platelet and monocyte activation.

  9. Data suggest that the monocyte chemoattractant protein-4 core promoter YY-1 (show YY1 Proteins) binding motif is functional, and modulates the transcriptional regulation of the MCP-4 gene.

  10. MCP-4 may be a critical molecule that links obesity and chronic inflammation.

Mouse (Murine) Chemokine (C-C Motif) Ligand 13 (CCL13) interaction partners

  1. Data indicate that a second-degree burn injury can initiate an immediate novel zonal degranulation of mast cell throughout all skin layers and a disruption of the epidermal tight junctions dependent on the nonredundant presence of mMCP4 and mMCP5 (show CMA1 Proteins).

  2. these results support the conclusion that mast cells can contribute to the initial lung injury induced by bleomycin through release of the MCPT4 chymase (show CMA1 Proteins).

  3. Mast cell chymase (show CMA1 Proteins) degrades the alarmins heat shock protein 70 (show HSP70 Proteins), biglycan (show BGN Proteins), HMGB1 (show HMGB1 Proteins), and interleukin-33 (IL-33 (show IL33 Proteins)) and limits danger-induced inflammation.

  4. Data from Mcp-4 (mast cell protease 4) knockout mice suggest Mcp-4 plays a pivotal role in the dynamic (in vivo and in vitro) conversion of systemic Big-endothelin-1 (show EDN1 Proteins) to endothelin-1 (show EDN1 Proteins) (1-31).

  5. MCs (show SMCP Proteins) exert protective functions after trauma, at least in part via mMCP-4, by suppressing exacerbated inflammation via their proteases.

  6. The effects of interactions between mMCP-4 and TNF (show TNF Proteins) in vivo by analyzing the features of a classic model of polymicrobial sepsis, were assessed.

  7. mMCP-4 plays two different roles in the pathogenesis of experimental BP, by both activating MMP-9 (show MMP9 Proteins) and by cleaving BP180 (show COL17A1 Proteins), leading to injury of the hemidesmosomes and extracellular matrix of the basement membrane zone.

  8. mMCP-4-deficient mice but not to mMCP-5 (show CMA1 Proteins)-deficient mice revealing nonredundant actions for these two MC proteases in a model of innate inflammatory injury with remodeling.

  9. MCP-4 contributes locally to the aggravation of glomerulonephritis by mediating a variety of proinflammatory effects.

  10. mice deficient in mast cells (Kit(W-sh/W-sh) [Wsh]) or mast cell chymase (Mcpt4(-/-)) have significantly decreased basal small intestinal permeability compared with wild-type (WT) mice

Chemokine (C-C Motif) Ligand 13 (CCL13) Protein Profile

Protein Summary

This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis.

Gene names and symbols associated with CCL13

  • chemokine (C-C motif) ligand 13 (CCL13)
  • mast cell protease 4 (Mcpt4)
  • CKb10 protein
  • Mcp-4 protein
  • Mcp4 protein
  • MMCP-4 protein
  • MMCP-4A protein
  • MMCP-4B protein
  • NCC-1 protein
  • NCC1 protein
  • SCYA13 protein
  • SCYL1 protein

Protein level used designations for CCL13

C-C motif chemokine 13 , CK-beta-10 , monocyte chemoattractant protein 4 , monocyte chemotactic protein 4 , new CC chemokine 1 , small inducible cytokine subfamily A (Cys-Cys), member 13 , small-inducible cytokine A13 , monocyte chemotactic protein-4 , MSMCP , myonase , serosal mast cell protease

GENE ID SPECIES
6357 Homo sapiens
445451 Canis lupus familiaris
17227 Mus musculus
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