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Chemokine (C-C Motif) Receptor 2 Proteins (CCR2)

CCR2 encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Additionally we are shipping CCR2 Antibodies (217) and CCR2 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCR2 729230 P41597
CCR2 12772 P51683
Rat CCR2 CCR2 60463 O55193
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Top CCR2 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days

CCR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Top referenced CCR2 Proteins

  1. Human CCR2 Protein expressed in Wheat germ - ABIN1329948 : Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014 (PubMed)

More Proteins for Chemokine (C-C Motif) Receptor 2 (CCR2) Interaction Partners

Human Chemokine (C-C Motif) Receptor 2 (CCR2) interaction partners

  1. CCR2 gene polymorphism (64I allele carriage) is a predisposing factor for allergy.

  2. data suggest that the CCR2-64I polymorphism is associated with the protective effect to development of cervical lesions as well as in the protection to HPV 16 infection.

  3. Ovarian cancer cells express both Hp and its receptor CCR2 but only after exposure to ascitic fluid, inducing moderated cell migration; results suggest that Hp-induced changes in the cell morphology, actin cytoskeleton structure, and migration ability of tumor cells, is possibly "preparing" these cells for the potential induction of the metastatic phenotype.

  4. The frequencies of the rare alleles of CCR2, ITGB3 (show ITGB3 Proteins), and 3'UTR of c-fms (show CSF1R Proteins) in the Old Believers are lower than in the sample of Novosibirsk Russians, and the rare allele of DBH (show DBH Proteins) is more frequent

  5. Among HIV-seropositive samples 3.4% were homozygous CCR2-64I mutants, 17.8%) were heterozygous,78.8% were CCR2 wild type.

  6. results suggest that senescent dermal fibroblasts recruit stem cells by secreting various factors and that the CCL2/CCR2 axis is one of the mechanisms underlying this phenomenon

  7. Association of hydrogen sulfide (show SQRDL Proteins) with alterations of monocyte chemokine (show CCL1 Proteins) receptors, CCR2 and CX3CR1 (show CX3CR1 Proteins) in patients with coronary artery disease

  8. A polymorphism in MCP-1 may be correlated with the development of non-small cell clung cancer (NSCLC) in the Han nationality of Northern China. However, the polymorphism in CCR-2 is not involved in NSCLC.

  9. Results show that nerve-released CCL2 supports prostate cancer migration and perineural invasion though CCR2-mediated signaling.

  10. Study shows the increase of CCR2 gene expression in monocytes of severe obstructive sleep apnea patients and that monocytic CCR2 gene expression can be induced under intermittent hypoxia which contributes to the chemotaxis and adhesion of monocytes.

Mouse (Murine) Chemokine (C-C Motif) Receptor 2 (CCR2) interaction partners

  1. Disruption of CCR2 enhanced tau pathology and reduced cavity volume in mild traumatic brain injury.

  2. In the absence of the rd8 allele, deficiency of CCR2 and CX3CL1 (show CX3CL1 Proteins) in mice leads to a mild form of retinal degeneration which is associated with the recruitment of macrophages, particularly to the subretinal space. This model enables to assess consequences of perturbed chemokine (show CCL1 Proteins) signaling, but it does not recapitulate cardinal (show CARD8 Proteins) age-related macular degeneration features.

  3. The results indicate that AMPK (show PRKAA1 Proteins) is a negative regulator of Ccr2 expression in RAW264.7 macrophages, and that the mechanism of action of AMPK (show PRKAA1 Proteins) inhibition of Ccr2 is mediated, in part, through the NF-kappaB (show NFKB1 Proteins) pathway.

  4. upon binding to a composite NFAT (show NFATC1 Proteins)/BCL6 (show BCL6 Proteins) regulatory element within the Ccl2 (show CCL2 Proteins) promoter, NFATc1 (show NFATC1 Proteins)/beta proteins release the BCL6 (show BCL6 Proteins)-dependent repression of Ccl2 (show CCL2 Proteins) gene in macrophages.

  5. results demonstrate the central role CCR2 plays in mediating leukocyte mobilization from the BM, and suggest a role for CCR2 inhibition in managing monocytes/macrophages-mediated chronic inflammatory conditions

  6. cellular fibrin uptake was diminished by elimination of CCR2-expressing cells.

  7. CCL2/CCR2 signaling pathway may provide a novel therapeutic target to prevent renal disease progression in patients with renovascular hypertension.

  8. In Ccr2(-/-) mice, in which monocyte-derived macrophage infiltration is impaired, silica administration induced diffuse PF with loose nodule formation and greater activation of tissue cells.

  9. IL-23 (show IL23A Proteins)/IL-1 (show IL1A Proteins)/IFNgamma/TNFalpha (show TNF Proteins)/T-bet/Eomesodermin (show EOMES Proteins)-driven circuit drives GM-CSF (show CSF2 Proteins)/IFNgamma-producing Th17 cell development.

  10. a Th1 response in the modulation of Th2 allergic inflammation, our findings also attribute an important role to the innate response mediated by TLR9, associated with the recruitment of CCR2-dependent monocytes.

CCR2 Protein Profile

Protein Summary

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.

Gene names and symbols associated with CCR2

  • chemokine (C-C motif) receptor 2 (CCR2)
  • chemokine (C-C motif) receptor 2 (Ccr2)
  • Cc-ckr-2 protein
  • CCR-2 protein
  • Ccr2a protein
  • Ccr2b protein
  • CD192 protein
  • Ckr2 protein
  • Ckr2a protein
  • Ckr2b protein
  • Cmkbr2 protein
  • MCP-1-R protein
  • mJe-r protein

Protein level used designations for CCR2

C-C chemokine receptor type 2 , MCP-1 receptor , monocyte chemoattractant protein 1 receptor , monocyte chemotactic protein 1 receptor , C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR) , C-C CKR-2 , CCR-2 , JE/FIC receptor , MIP-1 alphaR , chemoattractant protein-1 receptor , chemokine (C-C) receptor 2 , CC-CKR-2 , chemokine receptor CCR2 , MCP-1-R , chemokine receptor

729230 Homo sapiens
12772 Mus musculus
60463 Rattus norvegicus
484790 Canis lupus familiaris
574098 Macaca mulatta
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