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Chemokine (C-C Motif) Receptor 2 Proteins (CCR2)

CCR2 encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Additionally we are shipping CCR2 Antibodies (238) and CCR2 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCR2 729230 P41597
CCR2 12772 P51683
Rat CCR2 CCR2 60463 O55193
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Top CCR2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

CCR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced CCR2 Proteins

  1. Human CCR2 Protein expressed in Wheat germ - ABIN1329948 : Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014 (PubMed)

More Proteins for Chemokine (C-C Motif) Receptor 2 (CCR2) Interaction Partners

Human Chemokine (C-C Motif) Receptor 2 (CCR2) interaction partners

  1. Results of this study indicated that the CCL2-CCR2 axis was involved in the pathogenesis of oral lichen planus and was positively correlated with disease activity.

  2. sCCL2 production possibly will be associated with the adiposity and polymorphic phenotypes of CCL2 (show CCL2 Proteins) and CCR2, in Mexican-Mestizos with insulin (show INS Proteins) resistance

  3. Increased CCR2 expression is associated with bladder cancer metastasis.

  4. These findings suggested that the CCL2 (show CCL2 Proteins)/CCR2 chemokine (show CCL1 Proteins) signaling may regulate the epithelial-mesenchymal transition.

  5. CCR2 gene polymorphism (64I allele carriage) is a predisposing factor for allergy.

  6. data suggest that the CCR2-64I polymorphism is associated with the protective effect to development of cervical lesions as well as in the protection to HPV 16 infection.

  7. Ovarian cancer cells express both Hp and its receptor CCR2 but only after exposure to ascitic fluid, inducing moderated cell migration; results suggest that Hp-induced changes in the cell morphology, actin cytoskeleton structure, and migration ability of tumor cells, is possibly "preparing" these cells for the potential induction of the metastatic phenotype.

  8. The frequencies of the rare alleles of CCR2, ITGB3 (show ITGB3 Proteins), and 3'UTR of c-fms (show CSF1R Proteins) in the Old Believers are lower than in the sample of Novosibirsk Russians, and the rare allele of DBH (show DBH Proteins) is more frequent

  9. Among HIV-seropositive samples 3.4% were homozygous CCR2-64I mutants, 17.8%) were heterozygous,78.8% were CCR2 wild type.

  10. results suggest that senescent dermal fibroblasts recruit stem cells by secreting various factors and that the CCL2/CCR2 axis is one of the mechanisms underlying this phenomenon

Mouse (Murine) Chemokine (C-C Motif) Receptor 2 (CCR2) interaction partners

  1. CCR2(-/-) resident cardiac Macrophage favor a more antiinflammatory phenotype relative to WT controls

  2. Endothelial VCAM-1 targeted delivery of the CCR2 antagonist resulted in inhibition of pulmonary metastases both in a murine (MC-38GFP cells) and a human xenograft (patient-derived cells) model.

  3. To interrogate the role of CCR2 activation on Nf1 (show NF1 Proteins)(+/-) neointima formation, authors induced neointima formation by carotid artery ligation in Nf1 (show NF1 Proteins)(+/-) and WT mice with genetic deletion of either MCP1 (show CCL2 Proteins) or CCR2. Loss of MCP-1 (show CPT1B Proteins) or CCR2 expression effectively inhibited Nf1 (show NF1 Proteins)(+/-) neointima formation and reduced macrophage content in the arterial wall.

  4. involved in Staphylococcus aureus-induced MCP-1 (show CPT1B Proteins) production via NF-kB or p38-MAPK (show MAPK14 Proteins) signaling

  5. CCL2 and its receptor CCR2 are important for the formation of osteoclasts and foreign body giant cells.

  6. Disruption of CCR2 enhanced tau pathology and reduced cavity volume in mild traumatic brain injury.

  7. In the absence of the rd8 allele, deficiency of CCR2 and CX3CL1 (show CX3CL1 Proteins) in mice leads to a mild form of retinal degeneration which is associated with the recruitment of macrophages, particularly to the subretinal space. This model enables to assess consequences of perturbed chemokine (show CCL1 Proteins) signaling, but it does not recapitulate cardinal (show CARD8 Proteins) age-related macular degeneration features.

  8. The results indicate that AMPK (show PRKAA1 Proteins) is a negative regulator of Ccr2 expression in RAW264.7 macrophages, and that the mechanism of action of AMPK (show PRKAA1 Proteins) inhibition of Ccr2 is mediated, in part, through the NF-kappaB (show NFKB1 Proteins) pathway.

  9. upon binding to a composite NFAT (show NFATC1 Proteins)/BCL6 (show BCL6 Proteins) regulatory element within the Ccl2 (show CCL2 Proteins) promoter, NFATc1 (show NFATC1 Proteins)/beta proteins release the BCL6 (show BCL6 Proteins)-dependent repression of Ccl2 (show CCL2 Proteins) gene in macrophages.

  10. results demonstrate the central role CCR2 plays in mediating leukocyte mobilization from the BM, and suggest a role for CCR2 inhibition in managing monocytes/macrophages-mediated chronic inflammatory conditions

CCR2 Protein Profile

Protein Summary

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.

Gene names and symbols associated with CCR2

  • chemokine (C-C motif) receptor 2 (CCR2)
  • chemokine (C-C motif) receptor 2 (Ccr2)
  • Cc-ckr-2 protein
  • CCR-2 protein
  • Ccr2a protein
  • Ccr2b protein
  • CD192 protein
  • Ckr2 protein
  • Ckr2a protein
  • Ckr2b protein
  • Cmkbr2 protein
  • MCP-1-R protein
  • mJe-r protein

Protein level used designations for CCR2

C-C chemokine receptor type 2 , MCP-1 receptor , monocyte chemoattractant protein 1 receptor , monocyte chemotactic protein 1 receptor , C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR) , C-C CKR-2 , CCR-2 , JE/FIC receptor , MIP-1 alphaR , chemoattractant protein-1 receptor , chemokine (C-C) receptor 2 , CC-CKR-2 , chemokine receptor CCR2 , MCP-1-R , chemokine receptor

GENE ID SPECIES
729230 Homo sapiens
12772 Mus musculus
60463 Rattus norvegicus
484790 Canis lupus familiaris
574098 Macaca mulatta
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