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Chemokine (C-C Motif) Receptor 8 Proteins (CCR8)

CCR8 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Additionally we are shipping CCR8 Antibodies (100) and CCR8 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCR8 1237 P51685
CCR8 12776 P56484
Rat CCR8 CCR8 301066  
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Top CCR8 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details

CCR8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Chemokine (C-C Motif) Receptor 8 (CCR8) Interaction Partners

Human Chemokine (C-C Motif) Receptor 8 (CCR8) interaction partners

  1. findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 (show DUSP22 Proteins) rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease

  2. Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin.

  3. CCL1 (show CCL1 Proteins)-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis.

  4. Identification of human CCR8 as a CCL18 (show CCL18 Proteins) receptor.

  5. CCR8(+) myeloid cell subset is expanded in patients with cancer.

  6. Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes.

  7. C-terminal clipping of chemokine CCL1 (show CCL1 Proteins)/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity

  8. The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4 (show TLR4 Proteins)) pathways, both of which are present in chronic obstructive pulmonary disease patients.

  9. There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics.

  10. CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK (show EPHB2 Proteins)-dependent pathway

Mouse (Murine) Chemokine (C-C Motif) Receptor 8 (CCR8) interaction partners

  1. CCR8 negatively regulates migration of cutaneous dendritic cells from the skin to the draining lymph nodes in contact hypersensitivity by keeping these cells in the skin.

  2. Chemokine receptor (show CCR1 Proteins) CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages.

  3. A sustained donor Treg presence is critical for their beneficial properties, and that their survival depends on CCR8 and donor but not host CD11c (show ITGAX Proteins)(+) Aantigen presenting cells.

  4. Expression of CCR-8 in microglia was upregulated in the presence of CCL-1 (show CCL1 Proteins).

  5. C-terminal clipping of chemokine CCL1 (show CCL1 Proteins)/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity

  6. Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor (show CCR1 Proteins) C-C motif chemokine receptor 8 in mice.

  7. a key regulator of Th2 cell skin recruitment during IL-5 (show IL5 Proteins)-mediated allergic inflammation

  8. mediates increased responsiveness of murine eosinophils to TCA-3 (show CCL1 Proteins)

  9. Data from three different models plus an in vivo blocking study clearly show that the Th2 cell-mediated pathological response to ovalbumin (show OVA Proteins)-induced allergic airway inflammation is not critically CCR8-dependent.

  10. sulfation at specific positions of the N-terminal domain of mouse CCR8 is critical for its biological activity, whereas glycosylation has a minor influence

CCR8 Protein Profile

Protein Summary

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.

Gene names and symbols associated with CCR8

  • C-C chemokine receptor 8 like (CCR8L)
  • chemokine (C-C motif) receptor 8 (CCR8)
  • chemokine (C-C motif) receptor 8 (Ccr8)
  • chemokine (C-C motif) receptor 8 (LOC100345500)
  • C-C protein
  • C-C CKR-8 protein
  • CC-CKR-8 protein
  • CCR-8 protein
  • CCR8 protein
  • CCR8-L protein
  • CDw198 protein
  • CKR-8 protein
  • CKRL1 protein
  • Cmkbr8 protein
  • CMKBRL2 protein
  • CY6 protein
  • GPRCY6 protein
  • mCCR8 protein
  • TER1 protein

Protein level used designations for CCR8

chemokine (C-C motif) receptor 8 , C-C chemokine receptor type 8 , CC chemokine receptor 8 , CC chemokine receptor CHEMR1 , CC-chemokine receptor chemr1 , chemokine (C-C) receptor 8 , chemokine (C-C) receptor-like 2 , chemokine receptor-like 1 , C-C motif chemokine receptor 8

GENE ID SPECIES
776400 Gallus gallus
1237 Homo sapiens
407772 Bos taurus
12776 Mus musculus
301066 Rattus norvegicus
420718 Gallus gallus
693806 Macaca mulatta
100345500 Oryctolagus cuniculus
100725278 Cavia porcellus
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