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Chemokine (C-X-C Motif) Ligand 12 Proteins (CXCL12)

CXCL12 encodes a stromal cell-derived alpha chemokine member of the intercrine family. Additionally we are shipping CXCL12 Antibodies (189) and CXCL12 Kits (65) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CXCL12 6387 P48061
CXCL12 20315 P40224
CXCL12 24772  
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Top CXCL12 Proteins at antibodies-online.com

Showing 10 out of 150 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Cynomolgus Fc Tag 10 μg Log in to see 16 Days
$173.80
Details
HOST_Human Cells Human Fc Tag 10 μg Log in to see 16 Days
$173.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$577.50
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 16 Days
$173.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 10 μg Log in to see 16 Days
$173.80
Details
HOST_Escherichia coli (E. coli) Dog Un-conjugated 10 μg Log in to see 16 Days
$173.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$190.24
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$190.24
Details

CXCL12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Top referenced CXCL12 Proteins

  1. Human CXCL12 Protein expressed in Escherichia coli (E. coli) - ABIN2666699 : Shirozu, Nakano, Inazawa, Tashiro, Tada, Shinohara, Honjo: Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. in Genomics 1996 (PubMed)
    Show all 5 references for ABIN2666699

  2. Mouse (Murine) CXCL12 Protein expressed in Escherichia coli (E. coli) - ABIN2007172 : Bleul, Farzan, Choe, Parolin, Clark-Lewis, Sodroski, Springer: The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. in Nature 1997 (PubMed)
    Show all 5 references for ABIN2007172

  3. Dog (Canine) CXCL12 Protein expressed in Escherichia coli (E. coli) - ABIN2008901 : Orimo, Gupta, Sgroi, Arenzana-Seisdedos, Delaunay, Naeem, Carey, Richardson, Weinberg: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. in Cell 2005 (PubMed)
    Show all 5 references for ABIN2008901

  4. Human CXCL12 Protein expressed in Escherichia coli (E. coli) - ABIN2005762 : Sapède, Rossel, Dambly-Chaudière, Ghysen: Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 5 references for ABIN2005762

  5. Human CXCL12 Protein expressed in Human Cells - ABIN2002109 : Delgado, Clark-Lewis, Loetscher, Langen, Thelen, Baggiolini, Wolf: Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes. in European journal of immunology 2001 (PubMed)
    Show all 5 references for ABIN2002109

  6. Cynomolgus CXCL12 Protein expressed in Human Cells - ABIN2009688 : Kryczek, Wei, Keller, Liu, Zou: Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis. in American journal of physiology. Cell physiology 2007 (PubMed)
    Show all 5 references for ABIN2009688

  7. Human CXCL12 Protein expressed in Escherichia coli (E. coli) - ABIN413780 : Basu, Broxmeyer: Transforming growth factor-{beta}1 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1/CXCL12. in Blood 2005 (PubMed)
    Show all 4 references for ABIN413780

More Proteins for Chemokine (C-X-C Motif) Ligand 12 (CXCL12) Interaction Partners

Rhesus Monkey Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. these results demonstrate that a cross-talk exists between the TGF-beta1 (show TGFB1 Proteins) and SDF-1 pathways in choroid-retinal endothelial cells

  2. following optic nerve crush, the levels of endogenous SDF-1alpha and CXCR4 (show CXCR4 Proteins) increase in the retina and optic nerve, where activated glial cells may act as a source of increased SDF-1alpha protein.

  3. The CXCR7/CXCR4 (show CXCR4 Proteins)/CXCL12 axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.

Medaka Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. primordial germ cell movements are shown to be the consequence of a combination of active SDF1a and SDF1b-guided migration; both SDF1 co-orthologues show only partly overlapping expression pattern and cooperate in the correct positioning of the PGCs

Human Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. CXCL12 mRNA level significantly correlated with markers indicating tumour hypoxia in hepatocellular carcinoma. PD-L1 (show CD274 Proteins) expression was significantly increased in tumours with a high number of tumour-infiltrating lymphocytes. In Cox (show COX8A Proteins) proportional hazard analyses, high PD-L1 (show CD274 Proteins) expression and loss of nuclear CXCL12 expression showed significant prognostic value in terms of overall survival.

  2. The results indicate that 801G/A in CXCL12 may not play a major role in pathogenesis of preeclampsia in a Chinese Han population.

  3. Higher percentage of CXCR4 (show CXCR4 Proteins)-expressing lung metastatic cells compared to the corresponding primary tumors point to important functions of the CXCL12/CXCR4 (show CXCR4 Proteins) axis in late steps of metastasis

  4. we found that CXCR4 (show CXCR4 Proteins)-CXCL12/AKT (show AKT1 Proteins) axis regulates RhoA (show RHOA Proteins), Rac-1, and Cdc42 (show CDC42 Proteins) to modulate cell invasion and tumor metastasis. Together, these results demonstrate a role for CXCR4 (show CXCR4 Proteins) in ESCC metastasis and progression and suggest potential targets for therapeutic intervention.

  5. The SDF-1/CXCR4 (show CXCR4 Proteins) chemokine (show CCL1 Proteins) axis plays a key role in UM cell proliferation and migration.

  6. Low CXCL12 expression is associated with colon cancer.

  7. the current study revealed that CXCL12 which combined its receptors CXCR4 and CXCR7 together could promote cell migration and cell invasion of OSCC.

  8. Increased CXCL12 expression is associated with invasion in nasopharyngeal carcinoma.

  9. Gab1 has a role in regulating SDF-1-induced progression via inhibition of apoptosis pathway induced by PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/Bcl-2 (show BCL2 Proteins)/BAX (show BAX Proteins) pathway in human chondrosarcoma

  10. Data suggest that microRNA miR (show MLXIP Proteins)-454 specifically targets 3' untranslated region (3'-UTR) of stromal cell derived factor-1 (SDF-1) mRNA to inhibit its translation.

Mouse (Murine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. the present study indicates that the CXCL12/CXCR4 (show CXCR4 Proteins) signaling pathway is important during the development of cochleae in neonatal mice.

  2. crosstalk between astrocytic CXCL12 and microglial CXCR4 (show CXCR4 Proteins) in the pathogenesis of neuropathic pain.

  3. A model of SDF-1 regulation in the hypoxia pathway was constructed; the underlying mechanisms of SDF-1 kinetics and a novel incoherent feed forward loop regulating SDF-1 expression were proposed.

  4. We showed that CXCL12, a potent chemoattractant for CXCR4 (show CXCR4 Proteins)-expressing NSPCs, was upregulated in the ischemic lesion of N-PRbeta-KO mice.

  5. DPP-4 (show DPP4 Proteins) inhibition may have direct protective effects on the post-myocardial infarction heart by inducing an antiapoptotic effect and inhibiting a decrease in vessel number through the SDF-1a/CXCR4 (show CXCR4 Proteins)-mediated STAT3 (show STAT3 Proteins) signaling pathway.

  6. findings demonstrate that Twist-1 (show TWIST1 Proteins), which maintains BMSC at an immature state, endows them with an increased capacity for supporting hematopoiesis via direct activation of CXCL12 gene expression.

  7. confirm a pivotal role of the SDF-1/CXCR4/CXCR7 axis for chronic allograft vasculopathy development

  8. Time-dependent changes in endometrial hypoxia during menstruation correlated with the regulation of mRNAs encoding for the angiogenic genes Vegfa (show VEGFA Proteins) and Cxcl12.

  9. The results of this study findings the post-CNS-inflammation role of CXCL12 in augmenting the endogenous myelin/neuronal repair capacity in MS-like disease, likely via CXCL12/CXCR4 (show CXCR4 Proteins) autocrine signaling.

  10. CXCR4 (show CXCR4 Proteins)/CXCL12 signaling may control movement of epithelial progenitors from the dental stem cell niche.

Xenopus laevis Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. expression patterns of xSDF-1a, xCXCR4, and xCXCR7 during gastrulation; results suggest SDF-1 signaling supports migration of the mesendoderm cell cohort toward the animal pole and that activin/nodal signaling acts as a regulator of the expression of xSDF-1a and xCXCR4, but not xCXCR7

  2. SDF-1/CXCR4 chemokine (show CCL1 Proteins) signaling is involved in the migration and survival or in the differentiation of PGCs in Xenopus

  3. A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls.

  4. SDF-1 signaling is necessary for migrations of massive numbers of cells during gastrulation.

Pig (Porcine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. Polymorphisms in CXCL12 are significantly associated with immunological traits in Landrace piglets and have potential application value for marker-assisted selection of pig breeding with disease resistance.

  2. The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1/CXCR4 (show CXCR4 Proteins) axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.

Cow (Bovine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. There is a potential link between follicular SDF1/CXCR4 (show CXCR4 Proteins) activation and the regulation of ovulation-related genes in cows and horses.

  2. Polymorphism of intron 2 of the SDF1 gene in Galloway, Hereford, and Russian Black Pied cattle

CXCL12 Protein Profile

Protein Summary

This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CXCL12

  • chemokine (C-X-C motif) ligand 12 (CXCL12)
  • CXCL12 (LOC100304642)
  • stromal cell-derived factor 1a (sdf1a)
  • stromal cell-derived factor 1a (a-sdf1a)
  • chemokine (C-X-C motif) ligand 12 (Cxcl12)
  • chemokine (C-X-C motif) ligand 12 (cxcl12)
  • a-sdf1a protein
  • IRH protein
  • Pbsf protein
  • Scyb12 protein
  • SDF-1 protein
  • sdf1 protein
  • sdf1a protein
  • Tlsf protein
  • Tpar1 protein
  • xSDF-1 protein

Protein level used designations for CXCL12

chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) , chemokine CXCL12/SDF-1ALPHA , stromal cell-derived factor 1 , stromal cell-derived factor 1 isoform alpha , stromal cell-derived factor 1 isoform gamma , CXCL12 , stromal cell-derived factor 1a , intercrine reduced in hepatomas , pre-B cell growth-stimulating factor , 12-O-tetradecanoylphorbol 13-acetate repressed protein 1 , pre-B-cell growth-stimulating factor , thymic lymphoma cell-stimulating factor , C-X-C motif chemokine 12 , stromal-derived factor 1 , chemokine ligand 12b , stromal cell derived factor 1 , stromal cell-derived factor-1 beta , CXC chemokine , CXCL12 chemokine , SDF-1 gamma , Stromal cell-derived factor 1 , stromal cell-derived factor-1 gamma

GENE ID SPECIES
574334 Macaca mulatta
100173045 Pongo abelii
100304642 Ictalurus punctatus
100049305 Oryzias latipes
100170634 Oryzias latipes
6387 Homo sapiens
20315 Mus musculus
399030 Xenopus laevis
395180 Gallus gallus
449622 Canis lupus familiaris
494460 Sus scrofa
613811 Bos taurus
24772 Rattus norvegicus
100721137 Cavia porcellus
493806 Felis catus
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