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Chemokine (C-X-C Motif) Ligand 12 Proteins (CXCL12)

CXCL12 encodes a stromal cell-derived alpha chemokine member of the intercrine family. Additionally we are shipping CXCL12 Antibodies (180) and CXCL12 Kits (76) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CXCL12 6387 P48061
CXCL12 20315 P40224
CXCL12 24772  
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Top CXCL12 Proteins at antibodies-online.com

Showing 10 out of 145 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$577.50
Details
HOST_Human Cells Human Fc Tag 10 μg Log in to see 16 Days
$173.80
Details
HOST_Human Cells Cynomolgus Fc Tag 10 μg Log in to see 16 Days
$173.80
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 16 Days
$173.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 4 to 6 Days
$412.50
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 100 μg Log in to see 4 to 6 Days
$412.50
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 50 μg Log in to see 2 to 3 Days
$577.50
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Dog Un-conjugated 10 μg Log in to see 16 Days
$173.80
Details

CXCL12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Top referenced CXCL12 Proteins

  1. Dog (Canine) CXCL12 Protein expressed in Escherichia coli (E. coli) - ABIN2008901 : Bleul, Farzan, Choe, Parolin, Clark-Lewis, Sodroski, Springer: The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. in Nature 1997 (PubMed)
    Show all 5 references for ABIN2008901

  2. Cynomolgus CXCL12 Protein expressed in Human Cells - ABIN2009688 : Orimo, Gupta, Sgroi, Arenzana-Seisdedos, Delaunay, Naeem, Carey, Richardson, Weinberg: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. in Cell 2005 (PubMed)
    Show all 5 references for ABIN2009688

  3. Human CXCL12 Protein expressed in Escherichia coli (E. coli) - ABIN2005762 : Sapède, Rossel, Dambly-Chaudière, Ghysen: Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 5 references for ABIN2005762

  4. Human CXCL12 Protein expressed in Human Cells - ABIN2002109 : Delgado, Clark-Lewis, Loetscher, Langen, Thelen, Baggiolini, Wolf: Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes. in European journal of immunology 2001 (PubMed)
    Show all 5 references for ABIN2002109

  5. Human CXCL12 Protein expressed in Escherichia coli (E. coli) - ABIN413780 : Basu, Broxmeyer: Transforming growth factor-{beta}1 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1/CXCL12. in Blood 2005 (PubMed)
    Show all 4 references for ABIN413780

More Proteins for Chemokine (C-X-C Motif) Ligand 12 (CXCL12) Interaction Partners

Rhesus Monkey Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. these results demonstrate that a cross-talk exists between the TGF-beta1 (show TGFB1 Proteins) and SDF-1 pathways in choroid-retinal endothelial cells

  2. following optic nerve crush, the levels of endogenous SDF-1alpha and CXCR4 (show CXCR4 Proteins) increase in the retina and optic nerve, where activated glial cells may act as a source of increased SDF-1alpha protein.

  3. The CXCR7/CXCR4 (show CXCR4 Proteins)/CXCL12 axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.

Medaka Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. primordial germ cell movements are shown to be the consequence of a combination of active SDF1a and SDF1b-guided migration; both SDF1 co-orthologues show only partly overlapping expression pattern and cooperate in the correct positioning of the PGCs

Human Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. Study shows that serum concentrations of CXCL12 were significantly higher, while those of its receptor CXCR4 (show CXCR4 Proteins) were significantly lower in esophageal cancer (EC) patients suggesting that suggest that serum CXCR4 (show CXCR4 Proteins) and CXCl12 may improve the diagnosis of EC patients.

  2. Data suggest targeting the stromal cell-derived factor-1 (SDF-1)/chemokine receptor 4 (CXCR4) axis might provide a therapeutic strategy for endometrial cancer (EC) treatment.

  3. In breast cancer patients, CXCL12 exhibited significant differences in expression between primary tumor and lymph node metastasis tumor

  4. We conclude that the CXCL12 G801A polymorphism is a risk factor that increases susceptibility to gliomas in a subset of the general Han Chinese population.

  5. these results indicate that the chemokine receptor CXCR4 (show CXCR4 Proteins) and its ligand CXCL12 play important roles in the occurrence and development of bladder cancer.

  6. mRNA expression of SDF-1 was significantly elevated in colorectal cancer.

  7. CXCL12 could trigger epithelial to mesenchymal transition of breast cancer cells.

  8. that elevated serum CXCL12 level at admission was an independent diagnostic and prognostic marker in patients with acute ischemic stroke

  9. Its remarkable effect on inhibiting CXCR4 (show CXCR4 Proteins)/CXCL12-mediated adhesion and migration of AML (show RUNX1 Proteins) cells.

  10. Endomyocardial expression of SDF-1 is enhanced in inflammatory cardiomyopathy, positively correlates with myocardial fibrosis and identifies high-risk patients with suspected myocarditis.

Mouse (Murine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. confirm a pivotal role of the SDF-1/CXCR4/CXCR7 axis for chronic allograft vasculopathy development

  2. Time-dependent changes in endometrial hypoxia during menstruation correlated with the regulation of mRNAs encoding for the angiogenic genes Vegfa (show VEGFA Proteins) and Cxcl12.

  3. The results of this study findings the post-CNS-inflammation role of CXCL12 in augmenting the endogenous myelin/neuronal repair capacity in MS-like disease, likely via CXCL12/CXCR4 (show CXCR4 Proteins) autocrine signaling.

  4. CXCR4 (show CXCR4 Proteins)/CXCL12 signaling may control movement of epithelial progenitors from the dental stem cell niche.

  5. our present study provided evidence that SDF-1 mediated CSCs migration through CXCR4 (show CXCR4 Proteins) and CXCR7 via MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) and PI3K/Akt (show AKT1 Proteins) pathway

  6. Following fracture, a CXCL12(+)-BMP2 (show BMP2 Proteins)(+) perivascular cell population is recruited along the endosteum.

  7. Data suggest that the conditional chemokine (show CCL1 Proteins) CXCL12 line can be used as a powerful tool to manipulate CXCL12 signaling and function in vivo.

  8. SDF-1 expressed by liver sinusoidal endothelial cells can be a major player in the recruitment of hematopoietic stem and progenitor cells to the liver during extramedullary hematopoiesis induced by hematopoietic mobilizers

  9. EMMPRIN promotes tumor growth and metastasis by recruitment of bone marrow-derived cells through controlling secretion and paracrine signaling of SDF-1 and VEGF.

  10. Combination of bone morphogenetic protein-2 (show BMP2 Proteins) plasmid DNA with chemokine (show CCL1 Proteins) CXCL12 creates an additive effect on bone formation

Xenopus laevis Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. expression patterns of xSDF-1a, xCXCR4, and xCXCR7 during gastrulation; results suggest SDF-1 signaling supports migration of the mesendoderm cell cohort toward the animal pole and that activin/nodal signaling acts as a regulator of the expression of xSDF-1a and xCXCR4, but not xCXCR7

  2. SDF-1/CXCR4 chemokine (show CCL1 Proteins) signaling is involved in the migration and survival or in the differentiation of PGCs in Xenopus

  3. A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls.

  4. SDF-1 signaling is necessary for migrations of massive numbers of cells during gastrulation.

Pig (Porcine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. Polymorphisms in CXCL12 are significantly associated with immunological traits in Landrace piglets and have potential application value for marker-assisted selection of pig breeding with disease resistance.

  2. The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1/CXCR4 (show CXCR4 Proteins) axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.

Cow (Bovine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. There is a potential link between follicular SDF1/CXCR4 (show CXCR4 Proteins) activation and the regulation of ovulation-related genes in cows and horses.

  2. Polymorphism of intron 2 of the SDF1 gene in Galloway, Hereford, and Russian Black Pied cattle

CXCL12 Protein Profile

Protein Summary

This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CXCL12

  • chemokine (C-X-C motif) ligand 12 (CXCL12)
  • CXCL12 (LOC100304642)
  • stromal cell-derived factor 1a (sdf1a)
  • stromal cell-derived factor 1a (a-sdf1a)
  • chemokine (C-X-C motif) ligand 12 (Cxcl12)
  • chemokine (C-X-C motif) ligand 12 (cxcl12)
  • a-sdf1a protein
  • IRH protein
  • Pbsf protein
  • Scyb12 protein
  • SDF-1 protein
  • sdf1 protein
  • sdf1a protein
  • Tlsf protein
  • Tpar1 protein
  • xSDF-1 protein

Protein level used designations for CXCL12

chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) , chemokine CXCL12/SDF-1ALPHA , stromal cell-derived factor 1 , stromal cell-derived factor 1 isoform alpha , stromal cell-derived factor 1 isoform gamma , CXCL12 , stromal cell-derived factor 1a , intercrine reduced in hepatomas , pre-B cell growth-stimulating factor , 12-O-tetradecanoylphorbol 13-acetate repressed protein 1 , pre-B-cell growth-stimulating factor , thymic lymphoma cell-stimulating factor , C-X-C motif chemokine 12 , stromal-derived factor 1 , chemokine ligand 12b , stromal cell derived factor 1 , stromal cell-derived factor-1 beta , CXC chemokine , CXCL12 chemokine , SDF-1 gamma , Stromal cell-derived factor 1 , stromal cell-derived factor-1 gamma

GENE ID SPECIES
574334 Macaca mulatta
100173045 Pongo abelii
100304642 Ictalurus punctatus
100049305 Oryzias latipes
100170634 Oryzias latipes
6387 Homo sapiens
20315 Mus musculus
399030 Xenopus laevis
395180 Gallus gallus
449622 Canis lupus familiaris
494460 Sus scrofa
613811 Bos taurus
24772 Rattus norvegicus
100721137 Cavia porcellus
493806 Felis catus
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