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CXCR3 encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Additionally we are shipping CXCR3 Kits (43) and CXCR3 Proteins (7) and many more products for this protein.
Showing 10 out of 252 products:
Human Monoclonal CXCR3 Primary Antibody for FACS, IHC - ABIN4899102
Falk, Singh, Faber, Nissen, Hviid, Sørensen: Dysregulation of CXCR3 expression on peripheral blood leukocytes in patients with neovascular age-related macular degeneration. in Investigative ophthalmology & visual science 2014
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Human Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895557
Chihara, Aranami, Oki, Matsuoka, Nakamura, Kishida, Yokoyama, Kuroiwa, Hattori, Okamoto, Murata, Toda, Miyake, Yamamura: Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica. in PLoS ONE 2013
Show all 19 references for ABIN4895557
Human Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895563
Clay, Rodrigues, Harvey, Leutenegger, Esser: Distinct chemokine triggers and in vivo migratory paths of fluorescein dye-labeled T Lymphocytes in acutely simian immunodeficiency virus SIVmac251-infected and uninfected macaques. in Journal of virology 2005
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Mouse (Murine) Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895551
Christensen, de Lemos, Moos, Christensen, Thomsen: CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. in Journal of immunology (Baltimore, Md. : 1950) 2006
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Human Polyclonal CXCR3 Primary Antibody for EIA, FACS - ABIN951214
Zhou, Tang, Qin, Gayed, Li, Skokos, Kyriakides, Pober, Tellides: CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses. in The Journal of experimental medicine 2010
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Mouse (Murine) Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895543
Mackay, Rahimpour, Ma, Collins, Stock, Hafon, Vega-Ramos, Lauzurica, Mueller, Stefanovic, Tscharke, Heath, Inouye, Carbone, Gebhardt: The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. in Nature immunology 2013
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Mouse (Murine) Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895547
Funakoshi, Shimizu, Numata, Ato, Melchers, Ohnishi: BILL-cadherin/cadherin-17 contributes to the survival of memory B cells. in PLoS ONE 2015
Human Polyclonal CXCR3 Primary Antibody for ELISA, WB - ABIN1535574
Marchese, Heiber, Nguyen, Heng, Saldivia, Cheng, Murphy, Tsui, Shi, Gregor: Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. in Genomics 1996
Human Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895553
Tha-In, Metselaar, Tilanus, Groothuismink, Kuipers, de Man, Kwekkeboom: Intravenous immunoglobulins suppress T-cell priming by modulating the bidirectional interaction between dendritic cells and natural killer cells. in Blood 2007
Human Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895555
de-Oliveira-Pinto, Marinho, Povoa, de Azeredo, de Souza, Barbosa, Motta-Castro, Alves, Ávila, de Souza, da Cunha, Damasco, Paes, Kubelka: Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever. in PLoS ONE 2012
IP-10 (show CXCL10 Antibodies) complexes with CXCR3, which in turn activates the ERK1/2 (show MAPK1/3 Antibodies) pathway, thus resulting in upregulation of p-CREB (show CREB1 Antibodies) and increased vascular smooth muscle cell proliferation.
the CXCR3+/CCR5 (show CCR5 Antibodies)+ expression was higher in the neoplastic as compared to the hyperplastic nodules.
monocytes and lymphocytes cooperate to enhance migration towards CXCR3 chemokines and CCL5 (show CCL5 Antibodies) in COPD (show ARCN1 Antibodies)
CXCL10 (show CXCL10 Antibodies)/CXCR3 axis promotes gastric cancer cell invasion and migration by upregulating MMP-2 (show MMP2 Antibodies) and MMP-9 (show MMP9 Antibodies) production via PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway.
CXCR3 expression in chronic lymphocytic leukemia cells was a strong determinant of a worse clinical outcome.
Speculate that aberrant expression of CXCR3 in marginal zone lymphoma of the skin is associated with migration of lymphoma cells to the epidermis and could lead to an epidermotropic pattern.
CXCR3 role in autoimmune thyroiditis [review]
Both CXCL10 (show CXCL10 Antibodies) and CXCR3 appeared to be useful in differentiating T1R reaction in borderline leprosy while CXCR3 alone differentiated BT from BT-T1R
CXCR3 expression was upregulated in advanced gastric cancer and was associated with increased CD4 (show CD4 Antibodies)+, CD8 (show CD8A Antibodies)+ tumor-infiltrating lymphocyte infiltration and improved overall survival
CXCR3 was also linked to steatosis through inducing hepatic lipogenic genes
Circulating levels of chemokines that activate CXCR3 are elevated in non-obese diabetic (NOD) mice, consistent with clinical findings in human diabetes.
CXCR3 interacts with IL-10 (show IL10 Antibodies) secreted by CD8 (show CD8A Antibodies)+CD122 (show IL2RB Antibodies)+ regulatory T cells in a mouse model of Acute Lung Injury and promotes interferon-gamma (show IFNG Antibodies) and CXCL10 (show CXCL10 Antibodies) release.
This study demonstrates a previously unrecognized role of CXCR3 signaling in glial cells in negatively regulating Th17 cell expansion during experimental autoimmune encephalomyelitis
findings demonstrate that targeting CXCR3 is effective in both tumor and host compartments, and suggest that CXCR3 inhibition is likely to avoid adverse effects on host cells
Activation of the CXCL10 (show CXCL10 Antibodies)/CXCR3 pathway has an important role in retinal inflammation and neuronal injury after high intraocular pressure-induced ischemia.
STAT3 (show STAT3 Antibodies) in CD8 (show CD8A Antibodies)+ T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 (show CXCL10 Antibodies) Axis
CXCR3-mediated trafficking of regulatory T cells could represent a mechanism of homeostatic immunoregulation during diabetogeneesis.
These studies identify CXCR3-mediated trafficking at the tumour vascular interface as a critical checkpoint to effective T-cell-based cancer immunotherapy.
activated T cells display a subtle distance-dependent chemotaxis toward clusters of infected cells and this is mediated by CXCR3 and its ligands.
Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CXCR3 expression
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
chemokine (C-X-C motif) receptor 3
, C-X-C chemokine receptor type 3
, G protein-coupled receptor 9
, IP-10 receptor
, IP10 receptor
, Mig receptor
, chemokine (C-X-C) receptor 3
, interferon-inducible protein 10 receptor
, CXC chemokine receptor 3
, Interferon-inducible protein 10 receptor