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CCL18 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Additionally we are shipping CCL18 Antibodies (66) and CCL18 Kits (43) and many more products for this protein.
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Human CCL18 Protein expressed in - ABIN621128
García, Cidoncha, Bote, Hinchado, Ortega: Altered profile of chemokines in fibromyalgia patients. in Annals of clinical biochemistry 2014
Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 target gene CCL18, while induction of other STAT6-inducible genes such as SPINT2 remained unaffected by JMJD3.
There was no association between serial CCL18 concentrations with tumor response and overall survival.
CCL-18 is a promising biomarker in COPD (show ARCN1 Proteins), as it is associated with frequency of exacerbations, particularly with severe COPD (show ARCN1 Proteins) exacerbations requiring hospitalization, as well as with functional parameters and symptom scores.
Data suggested that CCL18 upregulated Slug (show SNAI2 Proteins) expression to promote epithelial-mesenchymal transition (EMT (show ITK Proteins)) and stem cell-like features by activating the mTOR (show FRAP1 Proteins) pathway in oral cancer.
An increased lung protein expression of PARC in chronic obstructive pulmonary disease patients
CCL18 can increase the invasive ability of non-small cell lung cancer cells by binding to its receptor Nir1.
Results demonstrate that high levels of CCL18 are present in ovarian cancer (OC) ascites and that CCL18 is an important component of ascites for the ascites-mediated migration of OC cells. Ascites and CCL18 stimulate the phosphorylation and expression of Pyk2 (show PTK2B Proteins), which is critical for mediated CCL18-induced migration.
Data suggest that circulating CCL18 and abdominal subcutaneous white adipose tissue-secreted CCL18 correlates with insulin (show INS Proteins) resistance and metabolic syndrome risk score; because CCL18 is macrophage-specific and associates with adipose immune gene expression, it may constitute a marker of adipose tissue inflammation (panniculitis).
Cytomegalovirus replication in the allograft causes an intrapulmonary increase of CCL-18 and CCL-20 (show CCL20 Proteins) and a systemic rise of CCL-20 (show CCL20 Proteins) serum levels. Strong intrapulmonary CCL-18 responses are associated with symptomatic HCMV disease, proposing that CCL-18 BALF levels could serve as a marker.
Study determined that CCL18 expression was up-regulated in ovarian carcinoma suggesting that CCL18 may play an important role in the pathogenicity of epithelial ovarian cancer through the induction of regulators and the activation of signaling pathways including mTORC2 (show CRTC2 Proteins) signaling pathways.
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses.
C-C motif chemokine 18
, CC chemokine PARC
, CC chemokine ligand 18
, alternative macrophage activation-associated CC chemokine 1
, chemokine (C-C), dendritic
, dendritic cell chemokine 1
, macrophage inflammatory protein 4
, pulmonary and activation-regulated chemokine
, small inducible cytokine A18
, small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
, small-inducible cytokine A18
, chemokine CCL18/PARC