Chemokine (C-C Motif) Receptor 4 Proteins (CCR4)

The protein encoded by CCR4 belongs to the G-protein-coupled receptor family . Additionally we are shipping CCR4 Antibodies (231) and CCR4 Kits (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCR4 104625 Q8K3P5
CCR4 287249 Q6AXU9
CCR4 1233 P51679
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Top CCR4 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Wheat germ Human Un-conjugated   2 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Cat Un-conjugated   5 applications Log in to see 1 to 2 Days

CCR4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus)
Human , ,

More Proteins for Chemokine (C-C Motif) Receptor 4 (CCR4) Interaction Partners

Mouse (Murine) Chemokine (C-C Motif) Receptor 4 (CCR4) interaction partners

  1. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

  2. CCR4 is critically involved in regional lymph node dendritic cell-Th17 cell interactions that are necessary for Th17 cell-mediated induction of antitumor CD8 (show CD8A Proteins)+ effector T cells in mice bearing B16 melanoma.

  3. CCR4 is involved in immunosuppression after severe sepsis and suggest that CCR4+ Regulatory T Cells negatively modulate the short and long-term immune responses.

  4. CCL22 (show CCL22 Proteins) was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells

  5. CCR4 is involved in regulating negative selection of polyclonal and T cell receptor (TCR) transgenic thymocytes

  6. results show that the IL-4 (show IL4 Proteins)/CCL22 (show CCL22 Proteins)/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators

  7. These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.

  8. that effective engagement of CCR4 by CCL17 (show CCL17 Proteins) involves two distinct binding domains and interaction with both is required for signaling

  9. NF-kappaB (show NFKB1 Proteins) signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role

  10. CCR4-expressing Th2cells play a critical role in the pathogenesis of bronchial asthma by producing Th2 cytokines.

Human Chemokine (C-C Motif) Receptor 4 (CCR4) interaction partners

  1. Chemokine (show CCL1 Proteins) receptors CCR3 (show CCR3 Proteins) and CCR4, and the mucosa specific chemokine (show CCL1 Proteins) CCL28 (show ENC1 Proteins) have predominant roles in oral wound healing by increasing human gingiva fibroblast proliferation, migration, and the secretion of IL-6 (show IL6 Proteins) and HGF (show HGF Proteins) and reducing the secretion of TIMP-1 (show TIMP1 Proteins).

  2. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

  3. The percentage of CXCR3 (show CXCR3 Proteins)(+) CD4 (show CD4 Proteins)(+) TEM (show CYLD Proteins) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA (show SELPLG Proteins)(+) CD4 (show CD4 Proteins)(+) TCM cells expressing CCR6 (show CCR6 Proteins)(+) or CCR4(+)CXCR3 (show CXCR3 Proteins)(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.

  4. Case Report: CCR4+ T-cell depletion by mogamulizumab treatment of adult T-cell leukaemia/lymphoma results in CD8 (show CD8A Proteins)-positive T-cell mediated dermatitis.

  5. CCL22 (show CCL22 Proteins)-specific antibodies reveal that engagement of two distinct binding domains on CCL22 (show CCL22 Proteins) is required for CCR4-mediated function.

  6. CCR4 mutation is an important determinant of the clinical course in ATLL cases, and that NS and FS mutations of CCR4 behave differently with respect to ATLL pathophysiology.

  7. Distinctive Treg associated CCR4-CCL22 (show CCL22 Proteins) expression profile with altered frequency of Th17/Treg cell in the immunopathogenesis of Pemphigus Vulgaris (show DSG3 Proteins).

  8. Data show that CCR4 was over-expressed in lymph node-negative human gastric cancer tissues and suggest its involvement in promoting tumor invasion probably, through up-regulation of MMP9 (show MMP9 Proteins).

  9. CCR4 C1014T and CCL22 (show CCL22 Proteins) C16A genetic variations were neither associated with the risk, nor with the progression of colorectal cancer in Iranian population

  10. Higher percentages of CCR4+ CD4 (show CD4 Proteins) TEM (show CYLD Proteins) cells in acute RSV infection were accompanied with higher percentages of CXCR3 (show CXCR3 Proteins)+ CD8 (show CD8A Proteins) TEM (show CYLD Proteins) cells, whereas the development of long-lived memory CXCR3 (show CXCR3 Proteins)+ CD4 (show CD4 Proteins) and CD8 (show CD8A Proteins) TCM cells seems to be compromised

CCR4 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

Gene names and symbols associated with CCR4

  • C-C motif chemokine receptor 4 (CCR4)
  • CCR4-NOT transcription complex, subunit 6 (Cnot6)
  • chemokine (C-C motif) receptor 4 (Ccr4)
  • C-C motif chemokine receptor 4 (Ccr4)
  • A230103N10Rik protein
  • AA407540 protein
  • AW456442 protein
  • C-C CKR-4 protein
  • CC-CKR-4 protein
  • CCR4 protein
  • CD194 protein
  • CHEMR1 protein
  • ChemR13 protein
  • CKR4 protein
  • Cmkbr4 protein
  • HGCN:14099 protein
  • K5-5 protein
  • LESTR protein
  • RGD1310783 protein
  • Sdf1r protein

Protein level used designations for CCR4

chemokine (C-C motif) receptor 4 , C-C chemokine receptor type 4-like , c-C chemokine receptor type 4-like , CCR4-NOT transcription complex subunit 6 , carbon catabolite repressor protein 4 homolog , cytoplasmic deadenylase , C-C CKR-4 , C-C chemokine receptor type 4 , CCR-4 , chemokine (C-C) receptor 4 , CC chemokine receptor 4 , CC-CKR-4 , fusin , leukocyte-expressed seven-transmembrane-domain receptor , C-C chemokine receptor 4

100397096 Callithrix jacchus
100445664 Pongo abelii
100585668 Nomascus leucogenys
104625 Mus musculus
287249 Rattus norvegicus
1233 Homo sapiens
403541 Canis lupus familiaris
408019 Bos taurus
12773 Mus musculus
171054 Rattus norvegicus
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