anti-Chimerin 1 (CHN1) Antibodies

CHN1 encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse CHN1 CHN1 108699 Q91V57
Anti-Rat CHN1 CHN1 84030 P30337
Anti-Human CHN1 CHN1 1123 P15882
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More Antibodies against Chimerin 1 Interaction Partners

Zebrafish Chimerin 1 (CHN1) interaction partners

  1. These findings demonstrate that a correct level of alpha2-chimaerin signaling is required for key oculomotor axon guidance decisions, and provide a zebrafish model for Duane Retraction Syndrome.

Mouse (Murine) Chimerin 1 (CHN1) interaction partners

  1. This study showed that, in the mouse, hippocampal alpha2-chimaerin acts in the late postnatal stages (juvenile and adolescence) to establish both the baseline level of the dendritic spine morphology and normal contextual fear-learning ability in adulthood

  2. Developmental alpha2-chimaerin activity is important for adult cognition.

  3. Chimaerins are RhoGTPase-activating proteins that are EphA4 (show EPHA4 Antibodies) effectors and have been implicated in a number of processes including growth cone collapse, axon guidance, dendritic spine development and the formation of corticospinal motor circuits.

  4. These findings establish a new alpha2-chimaerin-dependent mechanism underlying neuronal migration and proper functioning of the cerebral cortex and provide insights into the pathogenesis of seizure-related neurodevelopmental disorders.

  5. Chimaerin, one of the Rho GTPase (show RACGAP1 Antibodies) activating proteins, is transcriptionally up-regulated after exposure to neurotrophins in post-natal cerebellar neurons.

  6. lpha1-chimaerin is an activity-regulated Rho GTPase (show RACGAP1 Antibodies) regulator that is activated by phospholipase Cbeta-coupled cell surface receptors and contributes to pruning of dendritic arbors

  7. Rac (show AKT1 Antibodies)-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of Efnb3 (show EFNB3 Antibodies) forward signaling

  8. Our results reveal an alpha-chimaerin-dependent signaling pathway downstream of EphA4 (show EPHA4 Antibodies), which is essential for axon guidance decisions and neuronal circuit formation in vivo.

  9. These findings identify alpha2-chimaerin as an indispensable effector for EphA4 (show EPHA4 Antibodies) in cortical and spinal motor circuits.

Cow (Bovine) Chimerin 1 (CHN1) interaction partners

  1. These data indicate that as a consequence of weaning, which causes physiological stress and alters hepatic metabolism, chemerin (show RARRES2 Antibodies) protein expression within the liver is downregulated, indicating that chemerin (show RARRES2 Antibodies) plays a role in the upregulation of hepatic expression via its inhibitory effect on hepatic gluconeogenesis.

  2. Association between a single nucleotide polymorphism in the bovine chemerin (show RARRES2 Antibodies) gene and carcass traits

Human Chimerin 1 (CHN1) interaction partners

  1. reduced alpha1-chimaerin expression in the brain of Alzheimer's disease cases, suggesting a role in the upregulation of Rac1 activity during the disease process.

  2. The patients most similar belong to families with a small or absent cranial nerve VI and septo-optic hypoplasia who carry CHN1 mutations

  3. Analysis of the current pedigree expands the phenotypic spectrum of hyperactivating CHN1 mutations to include vertical strabismus (show VANGL2 Antibodies) and supraduction deficits in the absence of Duane retraction syndrome.

  4. Members of families segregating Duane retraction syndrome (DRS (show PNN Antibodies)) as an autosomal dominant trait should be screened for mutations in the CHN1 gene, enhancing genetic counseling and permitting earlier diagnosis.

  5. We found no evidence for a causative involvement of CHN1 mutations in congenital ocular motor anomalies different from autosomal dominant Duane's retraction syndrome

  6. study concludes that CHN1 mutations are not a major cause of Duane's retraction syndrome among individuals with sporadic disease

  7. we show that alpha-chimaerin is a Cdk5p35-binding protein; in transfected HeLa cells, Cdk5p35 and alpha-chimaerin displayed an overlapping distribution pattern

  8. These two pedigrees double the published pedigrees known to map to the DURS2 locus and can thus contribute toward the search for the DURS2 gene

  9. DRS (show PNN Antibodies) (Duane retraction syndrome) linked to the DURS2 locus is associated with bilateral abnormalities of many orbital motor nerves, and structural abnormalities of all EOMs except those innervated by the inferior division of CN3.

  10. Identify chimaerins as candidates for the downmodulation of Rac1 in T-lymphocytes and, in addition, uncover a novel regulatory mechanism that mediates their activation in T-cells.

Chimerin 1 (CHN1) Antigen Profile

Protein Summary

This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with anti-Chimerin 1 (CHN1) Antibodies

  • chimerin (chimaerin) 1 (chn1) antibody
  • chimerin 1 (chn1) antibody
  • chimerin (chimaerin) 1 (CHN1) antibody
  • chimerin (chimaerin) 1 (Chn1) antibody
  • chimerin 1 (CHN1) antibody
  • 0610007I19Rik antibody
  • 0710001E19Rik antibody
  • 1700112L09Rik antibody
  • 2900046J01Rik antibody
  • AI413815 antibody
  • ARHGAP2 antibody
  • chimaerin antibody
  • CHN antibody
  • DURS2 antibody
  • N-chimaerin antibody
  • NC antibody
  • RHOGAP2 antibody
  • wu:fr89a09 antibody
  • zgc:56160 antibody
  • zgc:92906 antibody

Protein level used designations for anti-Chimerin 1 (CHN1) Antibodies

N-chimaerin , alpha chimerin , z-chimaerin , chimerin (chimaerin) 1 , A-chimaerin , N-chimerin , NC , alpha-chimerin , alpha1 chimaerin , alpha2 chimaerin , alpha3-chimerin , chimaerin , rho GTPase-activating protein 2 , Rho GTPase-activating protein 2 , a2-chimaerin , chimaerin 1 , n-chimerin

GENE ID SPECIES
406273 Danio rerio
380027 Xenopus laevis
429021 Gallus gallus
108699 Mus musculus
84030 Rattus norvegicus
508266 Bos taurus
478805 Canis lupus familiaris
1123 Homo sapiens
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