Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Proteins (CHI3L1)

Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. Additionally we are shipping Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Antibodies (106) and Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Kits (62) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHI3L1 12654 Q61362
CHI3L1 1116 P36222
CHI3L1 89824 Q9WTV1
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Top Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Proteins at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag Human Chitinase 3-like 1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$280.50
Details
HOST_CHO Human His tag 10 μg Log in to see 15 to 19 Days
$170.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$666.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$717.00
Details

CHI3L1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , , , , , , ,
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Rat (Rattus) ,
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Top referenced Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Proteins

  1. Human CHI3L1 Protein expressed in Human Cells - ABIN2004130 : Nishikawa, Millis: gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. in Experimental cell research 2003 (PubMed)
    Show all 3 references for 2004130

  2. Mouse (Murine) CHI3L1 Protein expressed in Human Cells - ABIN2008418 : Recklies, Ling, White, Bernier: Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes. in The Journal of biological chemistry 2005 (PubMed)
    Show all 3 references for 2008418

  3. Human CHI3L1 Protein expressed in HEK-293 Cells - ABIN2180879 : Renkema, Boot, Au, Donker-Koopman, Strijland, Muijsers, Hrebicek, Aerts: Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. in European journal of biochemistry / FEBS 1998 (PubMed)
    Show all 3 references for 2180879

  4. Human CHI3L1 Protein expressed in CHO - ABIN1098537 : Bonneh-Barkay, Bissel, Wang, Fish, Nicholl, Darko, Medina-Flores, Murphey-Corb, Rajakumar, Nyaundi, Mellors, Bowser, Wiley: YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor. in The American journal of pathology 2008 (PubMed)
    Show all 2 references for 1098537

  5. Human CHI3L1 Protein expressed in HEK-293 Cells - ABIN2713970 : Cantó, Tintoré, Villar, Costa, Nurtdinov, Álvarez-Cermeño, Arrambide, Reverter, Deisenhammer, Hegen, Khademi, Olsson, Tumani, Rodríguez-Martín, Piehl, Bartos, Zimova, Kotoucova, Kuhle, Kappos et al.: Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes. ... in Brain : a journal of neurology 2015 (PubMed)

More Proteins for Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) Interaction Partners

Mouse (Murine) Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) interaction partners

  1. CHI3L1-mediated cell proliferation/survival involves partial downregulation of the pro-apoptotic S100A9 (show S100A9 Proteins) protein that is highly expressed during the acute phase of colitis, by binding to the S100A9 (show S100A9 Proteins) receptor, RAGE (show AGER Proteins) (Receptor for Advanced Glycation End products).

  2. IL-18 (show IL18 Proteins) is a potent stimulator of Chi3l1 and that Chi3l1 is an important mediator of IL-18 (show IL18 Proteins)-induced inflammatory, fibrotic, alveolar remodeling, and cytotoxic responses.

  3. CHI3L1 is induced during fungal infection, and it regulated antifungal innate immune responses in the cornea.

  4. Astrocytic expression of chitinase 3-like protein 1 limits the extent of both astrocytic and microglial/macrophage facets of neuroinflammation.

  5. Results do not support a role of BRP (show GDF5 Proteins)-39 in the pathogenesis of experimental autoimmune encephalitis.

  6. CHI3L1 was increased in plasma and brain tissue in experimental cerebral malaria, but targeted Chi3l1 deletion did not alter cytokine production or survival in this model.

  7. mechanism of BRP (show GDF5 Proteins)-39 in bleomycin-induced pulmonary fibrosis

  8. Sem7a and its receptors regulate Chi3l1 in pulmonary melanoma metastasis

  9. Data show that IL-1 (show IL1A Proteins)-induced transcriptin factor RelB (show RELB Proteins)/NF-kappa B p50 (show NFKB1 Proteins) Subunit complex formation was further promoted by oncostatin M (show OSM Proteins) and that these complexes directly bound to the secreted protein cartilage glycoprotein 39 (YKL-40) promoter.

  10. These results indicate that catalytically inactive BRP (show GDF5 Proteins)-39 and Ym1 (show CHI3L3 Proteins) are constitutive genes in normal mouse lung.

Human Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) interaction partners

  1. Findings show high level of both YKL-40 and GAP-43 (show GAP43 Proteins) in CSF (show CSF2 Proteins) of older women with suicidal ideation which suggest that a disrupted synaptic glial functioning and inflammation may be related to the aetiology of suicidal ideation in older adults.

  2. fibroblast-derived Chi3L1 as a novel key player in the complex reciprocal interactions of stromal cells that facilitate tumor progression and metastasis.

  3. Findings suggest that elevated serum YKL-40 levels are associated with the existence of uterine leiomyomas, and YKL-40 might be a potential adjunct biomarker for diagnosis of uterine leiomyomas.

  4. Collagen binds in two locations at the YKL-40 surface, potentially related to a role in fibrillar formation. Finally, heparin non-specifically binds at the YKL-40 surface, as predicted from structural studies

  5. This is the first report on the association between low-frequency and common variants in the chitinases-related genes CHIA and CHI3L1 with the intensity of specific IgE to ABA-1 in a population naturally exposed to Ascaris and with Bet v 1 in a Swedish population.

  6. results indicate that patients with CHI3L1 rs880633 variant genotypes TC+CC are at a higher risk of HCC (show FAM126A Proteins). CHI3L1 polymorphisms rs880633 or rs4950928 may be potential candidates for predicting poor HCC (show FAM126A Proteins) prognosis and clinical status.

  7. High YKL-40 levels were associated with a 2-fold increased risk of venous thromboembolism, but the association was not causal.

  8. 83 preterm infants with Bronchopulmonary dysplasia born <28-wk gestation and still inpatients at 36-wk corrected age received an echocardiogram and blood tests of B-type natriuretic peptide (BNP (show BNP Proteins)), troponin I, and YKL-40.

  9. Serum YKL-40 levels were increased in rheumatoid arthritis patients compared to controls. The highest levels were found in synovial fluid.

  10. this study shows that CHI3L1 levels in donor cells may be related to the risk of acute graft-versus-host disease and targeting CHI3L1 may be a promising clinical strategy to control acute graft-versus-host disease

Cow (Bovine) Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) interaction partners

  1. chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation

Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) Protein Profile

Protein Summary

Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.

Gene names and symbols associated with CHI3L1

  • chitinase 3-like 1 (Chi3l1)
  • chitinase 3-like 1 (cartilage glycoprotein-39) (CHI3L1)
  • chitinase 3-like 1 (cartilage glycoprotein-39) (Chi3l1)
  • ASRT7 protein
  • AW208766 protein
  • BP40 protein
  • Brp39 protein
  • CGP-39 protein
  • Chil1 protein
  • CLP-1 protein
  • GP-39 protein
  • GP38K protein
  • GP39 protein
  • HC-gp39 protein
  • HCGP-3P protein
  • hCGP-39 protein
  • MGP-40 protein
  • SPC-40 protein
  • SPS-40 protein
  • YKL-40 protein
  • YKL40 protein
  • YYL-40 protein

Protein level used designations for CHI3L1

CGP-39 , GP-39 , cartilage glycoprotein 39 , chitinase-3-like protein 1 , 39 kDa synovial protein , 38 kDa heparin-binding glycoprotein , signal-processing protein , 39 kDa whey protein , 40 kDa secretory signalling glycoprotein , cartilage glycoprotein-39 , chitinase-like protein 1 , signal processing protein , chitinase 3-like 1 protein , mammary gland protein 40

GENE ID SPECIES
12654 Mus musculus
1116 Homo sapiens
396865 Sus scrofa
286869 Bos taurus
89824 Rattus norvegicus
100860825 Capra hircus
443279 Ovis aries
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