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Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Proteins (CHI3L1)

Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. Additionally we are shipping Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Antibodies (66) and Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Kits (54) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHI3L1 12654 Q61362
CHI3L1 1116 P36222
CHI3L1 89824 Q9WTV1
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Top Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_CHO Human His tag 10 μg Log in to see 7 to 8 Days
$170.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$732.60
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$788.70
Details
HOST_Human Human His tag   10 μg Log in to see 11 Days
$187.50
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details

CHI3L1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , , , , ,
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Rat (Rattus) ,
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Top referenced Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Proteins

  1. Mouse (Murine) CHI3L1 Protein expressed in Human Cells - ABIN2008418 : Nishikawa, Millis: gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. in Experimental cell research 2003 (PubMed)
    Show all 3 references for ABIN2008418

  2. Human CHI3L1 Protein expressed in Human Cells - ABIN2004130 : Recklies, Ling, White, Bernier: Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes. in The Journal of biological chemistry 2005 (PubMed)
    Show all 3 references for ABIN2004130

  3. Human CHI3L1 Protein expressed in CHO - ABIN1098537 : Bonneh-Barkay, Bissel, Wang, Fish, Nicholl, Darko, Medina-Flores, Murphey-Corb, Rajakumar, Nyaundi, Mellors, Bowser, Wiley: YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor. in The American journal of pathology 2008 (PubMed)
    Show all 2 references for ABIN1098537

More Proteins for Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) Interaction Partners

Mouse (Murine) Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) interaction partners

  1. CHI3L1-mediated cell proliferation/survival involves partial downregulation of the pro-apoptotic S100A9 (show S100A9 Proteins) protein that is highly expressed during the acute phase of colitis, by binding to the S100A9 (show S100A9 Proteins) receptor, RAGE (show AGER Proteins) (Receptor for Advanced Glycation End products).

  2. IL-18 (show IL18 Proteins) is a potent stimulator of Chi3l1 and that Chi3l1 is an important mediator of IL-18 (show IL18 Proteins)-induced inflammatory, fibrotic, alveolar remodeling, and cytotoxic responses.

  3. CHI3L1 is induced during fungal infection, and it regulated antifungal innate immune responses in the cornea.

  4. Astrocytic expression of chitinase 3-like protein 1 limits the extent of both astrocytic and microglial/macrophage facets of neuroinflammation.

  5. Results do not support a role of BRP (show GDF5 Proteins)-39 in the pathogenesis of experimental autoimmune encephalitis.

  6. CHI3L1 was increased in plasma and brain tissue in experimental cerebral malaria, but targeted Chi3l1 deletion did not alter cytokine production or survival in this model.

  7. mechanism of BRP (show GDF5 Proteins)-39 in bleomycin-induced pulmonary fibrosis

  8. Sem7a and its receptors regulate Chi3l1 in pulmonary melanoma metastasis

  9. Data show that IL-1 (show IL1A Proteins)-induced transcriptin factor RelB (show RELB Proteins)/NF-kappa B p50 (show NFKB1 Proteins) Subunit complex formation was further promoted by oncostatin M (show OSM Proteins) and that these complexes directly bound to the secreted protein cartilage glycoprotein 39 (YKL-40) promoter.

  10. These results indicate that catalytically inactive BRP (show GDF5 Proteins)-39 and Ym1 (show CHI3L3 Proteins) are constitutive genes in normal mouse lung.

Human Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) interaction partners

  1. YKL-40 concentration in the serum of Kawasaki disease (KD) patients significantly increased during the acute disease phase compared with those of disease controls and healthy controls. Increased YKL-40 levels may provide a useful inflammatory marker for patients with KD

  2. CHI3L1 is associated with tumor metastasis and might be a prognostic biomarker for papillary thyroid carcinoma.

  3. YKL-40 expression was observed in 45 (58.4%) of 77 SVZ type II Glioblastomas (GBs (show GNB5 Proteins)) and in 17 (22.6%) of 75 SVZ type III GBs (show GNB5 Proteins)

  4. Independent validation with glioma patients tissue (n = 70) and normal brain tissue (n = 19) found PPIC (show PPIC Proteins), EMP3 (show EMP3 Proteins) and CHI3L1 were up-regulated in glioma tissue. Survival value validation showed that the three genes correlated with patient survival by Kaplan-Meir analysis, including grades, age and therapy.

  5. Time-dependent increase of chitinase1 in APP (show APP Proteins)/PS1 (show PSEN1 Proteins) double transgenic mice indicates that the level of chitinase1 is associated with decline of cognition.

  6. CHI3L1-mediated cell proliferation/survival involves partial downregulation of the pro-apoptotic S100A9 (show S100A9 Proteins) protein that is highly expressed during the acute phase of colitis, by binding to the S100A9 (show S100A9 Proteins) receptor, RAGE (show AGER Proteins) (Receptor for Advanced Glycation End products).

  7. Glycoprotein YKL-40 could be considered a biomarker of chronic graft-vs-host disease severity and activity

  8. High expression of YKL40 is associated with cholangiocarcinoma.

  9. Polymorphism in the CHI3L1 rs4950928 C allele is associated with rectal cancer.

  10. Unexpectedly and contrary to some other findings in cancer tissues, this study has shown a correlation between high YKL-40 tumor cell/matrix ratio and longer overall survival in human osteosarcoma.

Cow (Bovine) Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) interaction partners

  1. chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation

Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1) Protein Profile

Protein Summary

Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.

Gene names and symbols associated with CHI3L1

  • chitinase 3-like 1 (Chi3l1)
  • chitinase 3-like 1 (cartilage glycoprotein-39) (CHI3L1)
  • chitinase 3-like 1 (cartilage glycoprotein-39) (Chi3l1)
  • ASRT7 protein
  • AW208766 protein
  • BP40 protein
  • Brp39 protein
  • CGP-39 protein
  • Chil1 protein
  • CLP-1 protein
  • GP-39 protein
  • GP38K protein
  • GP39 protein
  • HC-gp39 protein
  • HCGP-3P protein
  • hCGP-39 protein
  • MGP-40 protein
  • SPC-40 protein
  • SPS-40 protein
  • YKL-40 protein
  • YKL40 protein
  • YYL-40 protein

Protein level used designations for CHI3L1

CGP-39 , GP-39 , cartilage glycoprotein 39 , chitinase-3-like protein 1 , 39 kDa synovial protein , 38 kDa heparin-binding glycoprotein , signal-processing protein , 39 kDa whey protein , 40 kDa secretory signalling glycoprotein , cartilage glycoprotein-39 , chitinase-like protein 1 , signal processing protein , chitinase 3-like 1 protein , mammary gland protein 40

GENE ID SPECIES
12654 Mus musculus
1116 Homo sapiens
396865 Sus scrofa
286869 Bos taurus
89824 Rattus norvegicus
100860825 Capra hircus
443279 Ovis aries
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