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CLCN6 encodes a member of the voltage-dependent chloride channel protein family. Additionally we are shipping Chloride Channel, Voltage-Sensitive 6 Antibodies (22) and many more products for this protein.
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This study demonistrated that clcn6 gene expression in mouse dorsal raphe nucleus
Chloride channel 6 (Clcn6) deficient mice have a later-onset form of mild neurologic dysfunction similar to neuronal ceroid lipofuscinosis.
ClC-6 protein is almost exclusively expressed in neurons of the central and peripheral nervous systems, with a particularly high expression in dorsal root ganglia.
These findings implicate the effect of rare coding variants in CLCN6 in Blood Pressure variation and offer new insights into Blood Pressure regulation.
A non-synonymous single nucleotide variation (SNV) was identified in the voltage-sensitive chloride channel 6 gene.
late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression
differential sorting of endogenous (late endosomal) versus overexpressed (early and recycling endosomal) ClC-6 is reminiscent of that of other late endosomal/lysosomal membrane proteins
This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown.
chloride transport protein 6
, chloride channel protein 6
, chloride channel 6
, chloride channel CLC-6