Chloride Channel 2 Proteins (CLCN2)

CLCN2 encodes a voltage-gated chloride channel. Additionally we are shipping Chloride Channel 2 Antibodies (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLCN2 12724 Q9R0A1
CLCN2 1181 P51788
Rat CLCN2 CLCN2 29232 P35525
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Top Chloride Channel 2 Proteins at

Showing 3 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

CLCN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
Human ,
, ,

More Proteins for Chloride Channel 2 (CLCN2) Interaction Partners

Zebrafish Chloride Channel 2 (CLCN2) interaction partners

  1. Identification and characterization of the zebrafish ClC (show CLCF1 Proteins)-2a/b/c chloride channel (show CLCA1 Proteins) orthologs.

Mouse (Murine) Chloride Channel 2 (CLCN2) interaction partners

  1. Genetic ablation of ClC-2 resulted in reduced gastric gland region, reduced parietal cell number, reduced H/K ATPase (show ATP4b Proteins), reduced tubulovesicles and reduced stimulated acid secretion.

  2. Data indicate that membrane protein MLC1 is crucial for proper localization of adhesion molecule (show NCAM1 Proteins) GlialCAM (show HEPACAM Proteins) and chloride channel (show CLCA1 Proteins) ClC-2, and for changing ClC-2 currents.

  3. Loss of ClC-2 is associated with increased development of DSS (show PMP22 Proteins)-induced colitis.

  4. The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1 (show KCNJ10 Proteins)), K(2P) channels (TREK-1 (show KCNK2 Proteins) and TWIK-1 (show KCNK1 Proteins)) and Cl- channels (ClC2).

  5. ClC-2 channels are required for colonic electroneutral absorption of NaCl and KCl.

  6. permeant Cl(-) ions contribute to V(m)-dependent gating of the broadly distributed ClC-2 Cl() channel.

  7. GABAA (show GABRg1 Proteins) receptor-mediated synaptic inputs from basket cells were modulated by ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.

  8. ClC-2 reduces barrier function in normal mucosa. Ultrastructural morphology of tight junctions and myosin light chain kinase (show MYLK Proteins) appear to be important to the function of ClC-2 in normal mucosa.

  9. these findings raise the possibility that ClC-2 expression plays a subtle neuroprotective role in the aging hippocampus

  10. Heterozygous nmf240 mice present with a reduced electroretinography light peak component suggests that CLCN2 is necessary for the generation of this response component.

Pig (Porcine) Chloride Channel 2 (CLCN2) interaction partners

  1. ClC-2-mediated intestinal Cl - secretion restores transepithelial resistance in ischemia-injured intestine.

Human Chloride Channel 2 (CLCN2) interaction partners

  1. The findings show that RGET691 of human ClC-2 (possible binding site) plays an important functional role in fatty acid activation of human ClC-2.

  2. Hyperpolarization activates CLC-2 mainly by driving intracellular anions into the channel pores.

  3. The extracellular domain of GlialCAM (show HEPACAM Proteins) is necessary for cell junction targeting and for mediating interactions with itself or with MLC1 and ClC-2.

  4. both ubiquitous (AP-1A) and epithelium-specific (AP-1B) forms of the tetrameric clathrin adaptor AP-1 (show FOSB Proteins) are capable of carrying out basolateral sorting of ClC-2.

  5. SPAK (show STK39 Proteins) and OSR1 (show OXSR1 Proteins) are powerful negative regulators of the cell volume regulatory Cl- channel ClC-2

  6. Correlation between CLC-2 gene expression and the cytoskeleton in human trabecular meshwork cells.

  7. Our observations substantiate the concept that ClC-2 is involved in brain ion and water homoeostasis

  8. JAK2 (show JAK2 Proteins) down-regulates ClC-2 activity and thus counteracts Cl(-) exit, an effect which may impact on cell volume regulation

  9. This study demonistrated that the first auxiliary subunit of ClC-2 and suggests that ClC-2 may play a role in the pathology of MLC disease.

  10. ClC-2 plays an important role in the modulation of tight junctions by influencing caveolar trafficking of tight junction protein occludin (show OCLN Proteins).

Chloride Channel 2 (CLCN2) Protein Profile

Protein Summary

This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Chloride Channel 2 Proteins (CLCN2)

  • chloride channel 2 (CLCN2)
  • novel protein similar to vertebrate chloride channel 2 (CLCN2) (CH211-117K11.1)
  • chloride channel protein 2 (EHI_142170)
  • chloride channel protein 2 (EHI_186860)
  • chloride channel 2 (Clcn2)
  • chloride channel protein 2 variant (CLC-2)
  • chloride channel, voltage-sensitive 2 (CLCN2)
  • chloride channel, voltage-sensitive 2 (Clcn2)
  • AL118368 protein
  • CIC-2 protein
  • clC-2 protein
  • Clc2 protein
  • CLCN2 protein
  • ECA2 protein
  • ECA3 protein
  • EGI3 protein
  • EGI11 protein
  • EGMA protein
  • EJM6 protein
  • EJM8 protein
  • LOC100150892 protein
  • nmf240 protein

Protein level used designations for Chloride Channel 2 Proteins (CLCN2)

chloride channel 2 , novel protein similar to vertebrate chloride channel 2 (CLCN2) , chloride channel protein 2 , PKA-activated chloride channel ClC-2G , clC-2

704709 Macaca mulatta
100125625 Ovis aries
100150892 Danio rerio
3405494 Entamoeba histolytica HM-1:IMSS
3410767 Entamoeba histolytica HM-1:IMSS
12724 Mus musculus
505569 Bos taurus
100135500 Cavia porcellus
397147 Sus scrofa
1181 Homo sapiens
29232 Rattus norvegicus
488106 Canis lupus familiaris
100009530 Oryctolagus cuniculus
425295 Gallus gallus
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