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Chloride Channel 3 Proteins (CLCN3)

CLCN3 encodes a member of the voltage-gated chloride channel (ClC) family. Additionally we are shipping Chloride Channel 3 Antibodies (87) and Chloride Channel 3 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLCN3 12725 P51791
CLCN3 1182 P51790
Rat CLCN3 CLCN3 84360 P51792
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Top Chloride Channel 3 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CLCN3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
, ,

More Proteins for Chloride Channel 3 (CLCN3) Interaction Partners

Mouse (Murine) Chloride Channel 3 (CLCN3) interaction partners

  1. Data suggest that ClC3/Clcn3 expression is up-regulated by mechanical stimulation (persistent static compression here) in osteoblastic cell line and appears to participate in mechanically sensitive osteogenesis and gene expression regulation.

  2. Our findings demonstrated that ClC-3 deficiency inhibits atherosclerotic lesion development, possibly via suppression of JNK (show MAPK8 Proteins)/p38 MAPK (show MAPK14 Proteins) dependent SR-A (show MSR1 Proteins) expression and foam cell formation.

  3. plasmalemmal ClC (show CLC Proteins)-3d, like ClC (show CLC Proteins)-3a, mediates Cd(2 (show CD2 Proteins)+)-sensitive outwardly rectifying anion currents and that ClC (show CLC Proteins)-3d is distinct from the molecular entities of acid- and volume-sensitive anion channels.

  4. alternative splicing of Clcn3 results in proteins with different subcellular localizations, but leaves the transport function of the proteins unaffected

  5. ClC-3 deficiency prevent preadipocytes against palmitate-induced apoptosis via suppressing ER stress, and also suggested that ClC-3 may play a role in regulating cellular apoptosis and disorders of glucose and lipid metabolism during T2DM.

  6. Hypotonic stress can induce endocytosis in bone marrow derived macrophages and ClC-3 plays a central role in the endocytic process.

  7. Integrin beta3 mediates cerebrovascular remodelling during hypertension via Src (show SRC Proteins)/ClC-3 signalling pathway.

  8. ClC-3 deficiency attenuates cerebrovascular remodelling possibly via the suppression of MMPs/TIMP expression and TGF-beta1 (show TGFB1 Proteins)/Smad3 (show SMAD3 Proteins) signalling pathway in this hypertension.

  9. CLC-3 confers chloride sensitivity to excitatory synapses, controls the magnitude of long-term potentiation and may provide a protective limit on Ca(2 (show CA2 Proteins)+) influx

  10. we determined the level of Autofluorescent storage material in chloride channel 3 gene-deficient mice both in response to aging and following mild global ischemia

Guinea Pig Chloride Channel 3 (CLCN3) interaction partners

  1. ClC-3 is specialized in mainly performing incomplete capacitive nontransporting cycles in intracellular membranes.

Xenopus laevis Chloride Channel 3 (CLCN3) interaction partners

  1. A local enhancement of CIC-3 expression at the leading edge of the wounded epidermis was found to be specific to closing wounds.

Human Chloride Channel 3 (CLCN3) interaction partners

  1. these results demonstrated that ClC-3 is involved in the proliferation and migration of osteosarcoma cell

  2. Data indicate that cytoplasmic chloride channel-3 (ClC-3) plays an active and key role in tumor metastasis and may be a valuable prognostic biomarker and a therapeutic target to prevent tumor spread.

  3. CLC3 is required in the activation and migration of human blood eosinophils.

  4. Authors summarize the function of CLC-3 in cancer and discuss the mechanisms by which CLC-3 contributes to proliferation, apoptosis and drug resistance in cancer cells. [Review]

  5. swelling-activated Cl currents and CLC-3 play a role in pulmonary artery smooth muscle cell proliferation, but CLC-3 channels do not underlie swelling in these cells

  6. ClC-3 deficiency inhibited Ang II (show AGT Proteins)-induced EPC (show TCF21 Proteins) apoptosis via suppressing ROS (show ROS1 Proteins) generation derived from NADPH oxidase (show NOX1 Proteins).

  7. our data suggest that the ClC-3 chloride channel (show CLCA1 Proteins) is an important target of cyclin D1 (show CCND1 Proteins). Cyclin D1 (show CCND1 Proteins) may regulate the functional activities of the chloride channel (show CLCA1 Proteins) via CDK4 (show CDK4 Proteins) and CDK6 (show CDK6 Proteins), and/or the expression of the chloride channel (show CLCA1 Proteins).

  8. Suggest that ClC-3 suppression causes the inhibition of Akt (show AKT1 Proteins) and autophagy, which can enhance the therapeutic benefit of cisplatin in U251 cells.

  9. K(Ca)3.1 and ClC-3 are expressed in tissue samples obtained from patients diagnosed with grade IV gliomas. Both K(Ca)3.1 and ClC-3 colocalize to the invading processes of glioma cells

  10. Data indicate in umbilical vein endothelial cells transfected with ClC-3 siRNA showed activation of NF-kappaB (show NFKB1 Proteins).

Chloride Channel 3 (CLCN3) Protein Profile

Protein Summary

This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with Chloride Channel 3 Proteins (CLCN3)

  • chloride channel 3 (CLCN3)
  • chloride channel protein 3 (AaeL_AAEL001752)
  • chloride channel protein 3 (PTRG_03131)
  • chloride channel protein 3 (BDBG_05668)
  • chloride channel protein 3 (MCYG_04420)
  • chloride channel, voltage-sensitive 3 (CLCN3)
  • chloride channel, voltage-sensitive 3 (clcn3)
  • Chloride channel protein 3 (clcn3)
  • chloride channel 3 (clcn3)
  • chloride channel 3 (Clcn3)
  • chloride channel, voltage-sensitive 3 (Clcn3)
  • ClC-3 protein
  • CLC3 protein
  • CLCN3 protein
  • fb78c02 protein
  • wu:fb78c02 protein

Protein level used designations for Chloride Channel 3 Proteins (CLCN3)

H(+)/Cl(-) exchange transporter 3 , chloride channel 3 , chloride channel protein 3 , Chloride channel protein 3 , chloride transporter ClC-3 , clC-3 , H(+)/Cl(-) exchange transporter 3-like , chloride channel Clc-3 , putative chloride channel ClC-3 , protein kinase C-regulated chloride channel

GENE ID SPECIES
522719 Bos taurus
471346 Pan troglodytes
5572287 Aedes aegypti
6341356 Pyrenophora tritici-repentis Pt-1C-BFP
8503901 Ajellomyces dermatitidis SLH14081
9229794 Arthroderma otae CBS 113480
100021050 Monodelphis domestica
100061225 Equus caballus
100074971 Ornithorhynchus anatinus
100174300 Pongo abelii
100216107 Xenopus (Silurana) tropicalis
100380301 Salmo salar
100404608 Callithrix jacchus
100581879 Nomascus leucogenys
559340 Danio rerio
12725 Mus musculus
100135501 Cavia porcellus
399089 Xenopus laevis
422432 Gallus gallus
1182 Homo sapiens
477354 Canis lupus familiaris
100156049 Sus scrofa
100008673 Oryctolagus cuniculus
84360 Rattus norvegicus
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