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Chloride Channel Kb Proteins (CLCNKB)

The protein encoded by CLCNKB is a member of the family of voltage-gated chloride channels. Additionally we are shipping CLCNKB Antibodies (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLCNKB 1188 P51801
Rat CLCNKB CLCNKB 79430 P51802
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Top CLCNKB Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 59 to 64 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 59 to 64 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

CLCNKB Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Chloride Channel Kb (CLCNKB) Interaction Partners

Mouse (Murine) Chloride Channel Kb (CLCNKB) interaction partners

  1. IGF-1 (show IGF1 Proteins), by stimulating ClC-K2 channels, promotes net Na(+) and Cl(-) reabsorption, thus reducing driving force for potassium secretion by the cortical collecting duct.

Human Chloride Channel Kb (CLCNKB) interaction partners

  1. Single loci of tag Single Nucleotide Polymorphisms of CLCNKA_B are not enough to increase the Essential Hypertension susceptibility, the combination of CLCNKA (show CLCNKA Proteins) SNP, salt, marine products, meat, edible oil consumption is associated with elevated risk

  2. results demonstrate that the carboxyl terminus of hClC-Kb is not part of the binding site for barttin (show BSND Proteins), but functionally modifies the interplay with barttin (show BSND Proteins).

  3. These results demonstrate that mutations in a cluster of hydrophobic residues within transmembrane domain 1 affect barttin (show BSND Proteins)-CLC-K interaction and impair gating modification by the accessory subunit

  4. we report here for the first time that ClC-Kb disease-causing mutations located around the selectivity filter can result in both reduced surface expression and hyperactivity in heterologous expression systems

  5. Case Report: 2 mutations in the CLCNKB gene, leading to a molecular diagnosis of Bartter syndrome type III in case of sudden infant death.

  6. R8W and G47R, two naturally occurring barttin (show BSND Proteins) mutations identified in patients with Bartter syndrome type IV, reduce barttin (show BSND Proteins) palmitoylation and CLC-K/barttin (show BSND Proteins) channel activity.

  7. HEK293 cells the potentiating effect of niflumic acid (NFA) on CLC-Ka/barttin (show BSND Proteins) and CLC-Kb/barttin (show BSND Proteins) channels seems to be absent while the blocking efficacy of niflumic acid and benzofuran derivatives observed in oocytes is preserved

  8. study investigated the functional consequences of seven mutations; four mutants carried no current whereas others displayed a 30-60 percent reduction in conductance as compared with wild-type ClC-Kb

  9. expands the association between CLCNKB and essential hypertension to a non-European ancestry population

  10. This article presents the case of a patient with hypokalaemia caused by CLCNKB gene mutation hard to categorise as GS or BS type 3.

Xenopus laevis Chloride Channel Kb (CLCNKB) interaction partners

  1. The open probability and mean open time of ClC-2 (show CLCN2 Proteins) was voltage dependent, decreasing dramatically as the patches were depolarized. ClC-2 (show CLCN2 Proteins) is uniquely suitable to promote anion secretion with little anion reabsorption.

CLCNKB Protein Profile

Protein Summary

The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Chloride Channel Kb Proteins (CLCNKB)

  • chloride channel, voltage-sensitive Kb (CLCNKB)
  • similar to chloride channel (putative) (CLCNKB)
  • chloride channel Kb (CLCNKB)
  • chloride channel K (clcnk)
  • chloride channel Ka (CLCNKA)
  • chloride channel Kb (Clcnkb)
  • chloride channel, voltage-sensitive Ka (CLCNKA)
  • chloride channel, voltage-sensitive Kb (Clcnkb)
  • chloride channel, voltage-sensitive Kb (clcnkb)
  • ClC-k protein
  • ClC-K2 protein
  • ClC-K2L protein
  • Clc-Ka protein
  • clc-kb protein
  • Clck2 protein
  • clckb protein
  • Clcnk1l protein
  • CLCNKA protein
  • clcnka-A protein
  • CLCNKB protein
  • clk-k2 protein
  • DKFZp469N0132 protein
  • x6clck protein
  • xCIC-K protein
  • xClC-K protein
  • zgc:64141 protein

Protein level used designations for Chloride Channel Kb Proteins (CLCNKB)

chloride channel Kb , chloride channel Ka , CIC-K , chloride channel protein ClC-Kb-like , chloride channel K1-like; putative basolateral cTAL chloride channel ClC-Ka , chloride channel protein ClC-Kb , clC-K2 , putative basolateral mTAL chloride channel ClC-Ka , Chloride channel protein ClC-Kb , chloride channel protein ClC-Ka , clC-K1 , chloride channel, kidney, B , chloride channel K2

703476 Macaca mulatta
428190 Gallus gallus
456470 Pan troglodytes
100171573 Pongo abelii
393353 Danio rerio
100017912 Monodelphis domestica
100400180 Callithrix jacchus
100590605 Nomascus leucogenys
538145 Bos taurus
56365 Mus musculus
100009213 Oryctolagus cuniculus
1188 Homo sapiens
487422 Canis lupus familiaris
79430 Rattus norvegicus
378616 Xenopus laevis
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